An unusual presentation of extramedullary plasmacytoma occurring sequentially in the testis, subcutaneous tissue, and heart

Abstract

Extramedullary plasmacytoma (EMP) is a rare neoplasm of soft tissue that usually arises in the respiratory tract, nasal cavity, sinuses, and nasopharynx. It is even more uncommon for it to arise either in the testis or heart. We report the presentation of a case where plasmacytomas were found sequentially in the testis, subcutaneous tissue, and heart. EMP usually has a good prognosis except when it involves the heart. Our patient survived for only 15 months post autologous hematopoietic stem cell transplantation. Am. J. Hematol. 67:194-196, 2001.

High-dose melphalan followed by radical radiotherapy for the treatment of massive plasmacytoma of the chest wall

“…8 The published data relating to the role of high-dose therapy are restricted to a few isolated case reports of patients with multiple plasmacytomas, which do not address the issue of tumour size. 9,10 In the light of studies demonstrating that for patients who present with massive plasmacytomas, radiotherapy alone is unlikely to result in local control or cure, we employed a treatment strategy incorporating the use of initial VAD chemotherapy, usually reserved for the treatment of multiple myeloma, followed by high-dose chemotherapy and finally radiotherapy to encompass any residual mass. This treatment was well tolerated and produced a durable remission in one patient.…”

“…[8][9][10] . Relatively few studies have addressed the impact of tumour size on treatment outcome for plasmacytoma.…”

Testicular Plasmacytoma as Initial Presentation of Multiple Myeloma

“…In order to make accurate diagnosis, immunologic staining for CD 138, CD 79a and monoclonal antibody VS 38 can be used [4] . Additionally, immunostaining will reveal IgG, IgD or IgA light chains; IgA being the most common [7] . The treatment of choice for testicular plasmacytoma is high inguinal orchiectomy.…”

“…Generally the prognosis of EMP without evidence of multiple myeloma is good with 5-year survival rates as high as 70% and median survival time around 8 years [6], [7] . In general, EMPs outside of the head and neck locations have a poorer prognosis [8] .…”

A case report of tracheal extramedullary plasmacytoma

“…EMP can involve any extraosseous organs, but it predominantly affects the head and neck areas. Any extra-osseous organ may also be involved [1,2] . Tracheal involvement is a rare fi nding.…”