An unusual presentation of primary cutaneous amyloidosis

Amyloid is a protein derived from at least 20 different substances. Once misfolded, it results in a group of cutaneous and systemic conditions. Primary localized cutaneous amyloidosis of keratinocyte origin is a very common subtype that can manifest either as lichen or macular amyloidosis, lacking systemic involvement. Lichen amyloidosis often presents as multiple hyperpigmented papules on the lower extremities whereas macular amyloidosis is classically characterized by dark brown rippled macules on the interscapular area. Review of the literature reveals that in addition to the classical presentation of primary localized cutaneous amyloidosis there exists a plethora of various manifestations that can be grouped into either geographic or morphologic categories. This review provides clinicians with the intimate knowledge of these presentations and summarizes the available treatment modalities. Key PointsPrimary localized cutaneous amyloidosis is a frequently encountered skin condition with a heterogeneous spectrum of clinical manifestations.Classifying the clinical spectrum into geographic and morphological categories assists dermatologists in the timely recognition of the correct diagnosis.

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Macular amyloidosis diagnostic outcomes of skin biopsy: A systematic review

Alhawas,

Obaid,

Alfawzan

et al. 2024

J Cutan Pathol

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Macular amyloidosis (MA) is a primary localized cutaneous amyloidosis, characterized by amyloid deposition in the papillary dermis. The clinical presentation includes pruritic hyperpigmented macules and patches with a reticulated or rippled pattern, primarily found on the upper back and extremities. Biopsy is an essential diagnostic tool for confirming MA. This systematic review focused on the biopsy outcomes in patients diagnosed with MA.

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An unusual presentation of primary cutaneous amyloidosis

Cited by 5 publications

References 4 publications

Treatment of pigmentation disorders in association with systemic diseases

Treatment of pigmentation disorders in association with systemic diseases

Primary Localized Cutaneous Amyloidosis of Keratinocyte Origin: An Update with Emphasis on Atypical Clinical Variants

Macular amyloidosis diagnostic outcomes of skin biopsy: A systematic review

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