An Unusual Presentation of Wegener Disease of the Cervix

Abstract

: A review of previously published cases of Wegener granulomatosis involving the uterine cervix is presented.We report the first case of Wegener granulomatosis involving the cervix without antecedent diagnosis or treatment of Wegener granuloma in any other organ.

Involvement of Uterine Cervix as the First Manifestation of Granulomatosis With Polyangiitis

“…To our knowledge, only 6 cases have been previously reported, [3][4][5][6][7][8] and the occurrence of cervical abnormalities as the first manifestation has been described in only a single case. 4 In a cohort of 158 patients with diagnosis of GPA, biopsy-proven granulomatosis of the cervix was reported in less than 1% of patients. 9 As previously described, 10 GPA is a multisystem disease that may initially present with manifestations of granulomatosis without vasculitis.…”

Granulomatosis with Polyangiitis-Mimicking Advanced Gynecological Cancer: A Case Report and Systematic Review of the Literature

“…Our systematic review identified 19 patients with GPA and genital tract involvement [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Among them 11/19 (58%) had primary disease, and 8/19 (42%) had recurrence.…”

“…Once studies with patients with MPA or EGPA (5) were removed, a total of 17 studies fulfilled all inclusion criteria and were selected for full-text evaluation and systematic review [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. After reviewing the 17 articles, 18 patients were identified as GPA with gynecological involvement (two patients reported by Stone et al) [12].…”

“…The results are shown in Tables 1 and 2. In thirteen of the 19 patients (68%) [14][15][16][17][18][20][21][22][24][25][26][27][28],including our case, the authors considered gynecologic cancer as the first possibility of diagnosis. Among them, 11 (58%) thought they were dealing with cervical cancer [14][15][16][17][18]21,22,[24][25][26][27][28].…”

“…In thirteen of the 19 patients (68%) [14][15][16][17][18][20][21][22][24][25][26][27][28],including our case, the authors considered gynecologic cancer as the first possibility of diagnosis. Among them, 11 (58%) thought they were dealing with cervical cancer [14][15][16][17][18]21,22,[24][25][26][27][28]. Isolated genital involvement and multi-site involvement were present in 10 and in 9 out of 19 patients, respectively (43%).…”