An unusual sterol from the mushroom Stropharia rugosoannulata

Wu, Jing; Suzuki, Tomohiro; Choi, Jae-Hoon; Yasuda, Nobuhiro; Noguchi, Keiichi; Hirai, Hirofumi; Kawagishi, Hirokazu

doi:10.1016/j.tetlet.2013.06.142

Cited by 14 publications

(7 citation statements)

References 5 publications

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“…From the fruiting bodies of the mushroom Stropharia rugosoannulata, an unusual sterol with an unprecedented ether ring (70) was isolated. This mushroom is known as saketsubatake in Japanese and wine-cap stropharia in English [80]. Ergopyrone (71), an extraordinary styrylpyrone-fused ergosterol derivative, was isolated and structurally characterized from the mushroom Gymnopilus orientispectabilis.…”

Section: Figure 4 (A)mentioning

confidence: 99%

Fascinating Furanosteroids and Their Pharmacological Profile

Dembitsky

2023

Molecules

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This review article delves into the realm of furanosteroids and related isoprenoid lipids derived from diverse terrestrial and marine sources, exploring their wide array of biological activities and potential pharmacological applications. Fungi, fungal endophytes, plants, and various marine organisms, including sponges, corals, molluscs, and other invertebrates, have proven to be abundant reservoirs of these compounds. The biological activities exhibited by furanosteroids and related lipids encompass anticancer, cytotoxic effects against various cancer cell lines, antiviral, and antifungal effects. Notably, the discovery of exceptional compounds such as nakiterpiosin, malabaricol, dysideasterols, and cortistatins has revealed their potent anti-tuberculosis, antibacterial, and anti-hepatitis C attributes. These compounds also exhibit activity in inhibiting protein kinase C, phospholipase A2, and eliciting cytotoxicity against cancer cells. This comprehensive study emphasizes the significance of furanosteroids and related lipids as valuable natural products with promising therapeutic potential. The remarkable biodiversity found in both terrestrial and marine ecosystems offers an extensive resource for unearthing novel biologically active compounds, paving the way for future drug development and advancements in biomedical research. This review presents a compilation of data obtained from various studies conducted by different authors who employed the PASS software 9.1 to evaluate the biological activity of natural furanosteroids and compounds closely related to them. The utilization of the PASS software in this context offers valuable advantages, such as screening large chemical libraries, identifying compounds for subsequent experimental investigations, and gaining insights into potential biological activities based on their structural features. Nevertheless, it is crucial to emphasize that experimental validation remains indispensable for confirming the predicted activities.

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Section: Figure 4 (A)mentioning

confidence: 99%

Fascinating Furanosteroids and Their Pharmacological Profile

Dembitsky

2023

Molecules

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“…Triterpenes have anti-tumor activity [ 62 ], and the content of triterpene in S. rugoso-annulata is 1.42% [ 2 ]. S. rugoso-annulata contains a variety of sterols, including ergosterol, seven sterols with unique carbon skeletons, four sterols named strophasterol A, B, C, and D, and two sterols with a unique ether ring structure (C 28 H 44 O 4 and C 30 H 50 O 3 ) [ 57 , 58 , 63 , 64 , 65 ]. Sterols in S. rugoso-annulata have bioactivities such as inhibiting osteoclast formation, inhibiting fungi growth, weakening endoplasmic reticulum stress to protect neuronal cells, and inhibiting toxic carotenoids [ 4 , 57 , 58 ].…”

Section: Bioactive Components Of S Rugoso-annulatamentioning

confidence: 99%

Nutritional, Bioactive, and Flavor Components of Giant Stropharia (Stropharia rugoso-annulata): A Review

Huang

et al. 2023

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Giant Stropharia (S. rugoso-annulata) is an edible mushroom recommended for consumption by the Food and Agriculture Organization of the United Nations. It possesses significant culinary and medicinal functionalities. The characteristics of this mushroom include high protein content, abundant bioactive compounds, delicious and sweet taste, and pleasant aroma. In recent years, the S. rugoso-annulata industry has seen strong growth, especially in China. This article presents the first comprehensive and systematic review of the nutritional, bioactive, and flavor components of S. rugoso-annulata, as well as their influencing factors. This article provides scientific evidence for the production of high-quality S. rugoso-annulata mushrooms, the extraction of bioactive components, post-harvest storage, and culinary processing, aiming to promote the consumption of S. rugoso-annulata and the health of consumers.

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“…Wu et al [66] reported the isolation of a new sterol bearing 5b,9b-dihydroxy groups (105) from St. rugosoannulata ( Fig. 1.16).…”

Section: Sterols Bearing 5a9a-epidioxy and 5b9b-dihydroxy Groupsmentioning

confidence: 99%