An up-to-date overview of sublingual sufentanil for the treatment of moderate to severe pain

Porela‐Tiihonen, Susanna; Kokki, Hannu; Kokki, Merja

doi:10.1080/14656566.2020.1766025

Cited by 13 publications

(12 citation statements)

References 43 publications

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“…An the comparison of VAS scores of the two drugs showed no statistical difference. In addition, a large number of studies have shown the significant role of opioids in acute analgesia [15][16][17], and the results of this part of the study was consistent with existing literature reports. That is, compared with celecoxib and etoricoxib, acetaminophen dihydrocodeine had better acute analgesic effect.…”

Section: Discussionsupporting

confidence: 90%

A retrospective analysis of the effects of different analgesics on the pain of patients with traumatic thoracolumbar fractures in the peri-treatment period

et al. 2021

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Objective To analyze and compare the effects of peri-treatment analgesics on acute and chronic pain and postoperative functional recovery of patients with thoracolumbar fractures, so as to guide the clinical drug use. Methods Seven hundred nineteen patients with thoracolumbar fractures were collected and divided into acetaminophen dihydrocodeine, celecoxib, and etoricoxib groups. The main indicators were the degree of postoperative pain (visual analog scale (VAS)), the incidence of chronic pain and postoperative functional recovery (Oswestry dysfunction index (ODI) and Japanese Orthopedics Association score (JOA)), which were continuously tracked through long-term telephone follow-up. The correlation analysis of ODI-pain score, peri-treatment VAS score, and ODI index was performed, and bivariate regression analysis was conducted to understand the risk factors for chronic pain. Results Regression analysis showed that severe spinal cord injury and peri-treatment use of acetaminophen dihydrocodeine were both one of the risk factors for postoperative chronic pain. But there were no statistically conspicuous differences in basic characteristics, preoperative injury, and intraoperative conditions. Compared with the other two groups, patients in the acetaminophen dihydrocodeine group had longer peri-therapeutic analgesic use, higher pain-related scores (VAS 1 day preoperatively, VAS 1 month postoperatively, and ODI-pain 1 year postoperatively), higher VAS variation, higher incidence of chronic pain 1 year after surgery, and higher ODI index. And other ODI items and JOA assessments showed no statistically significant differences. In addition, the correlation analysis showed that the peri-treatment pain score was correlated with the severity of postoperative chronic pain. Conclusion Although the peri-treatment analgesic effect of acetaminophen dihydrocodeine is good, it is still necessary to combine analgesics with different mechanisms of action for patients with severe preoperative pain of thoracolumbar fracture, so as to inhibit the incidence of postoperative chronic pain and improve the quality of postoperative rehabilitation.

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Section: Discussionsupporting

confidence: 90%

A retrospective analysis of the effects of different analgesics on the pain of patients with traumatic thoracolumbar fractures in the peri-treatment period

et al. 2021

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“…In addition, the time to reach the peak plasma concentration was higher following sublingual administration in the study. This slower absorption and lower bioavailability (47-57%) make sublingual sufentanil a desirable analgesic agent with a lower risk of apnea compared to the intravenous form [ 73 ]. The onset of analgesia after a single dose of 30 µg sublingual sufentanil is 15 - 30 min, reaching a peak effect at about 60 min and lasting about 180 min [ 72 , 73 ].…”

Section: Sublingually Administered Analgesic Agentsmentioning

confidence: 99%

Improving the Emergency Department Management of Sickle Cell Vaso-Occlusive Pain Crisis: The Role and Options of Sublingual and Intranasally Administered Analgesia

2023

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Vaso-occlusive crisis (VOC), characterized by periods of excruciating pain is the most common clinical manifestation of sickle cell disease (SCD), often resulting in emergency room presentation. These patients often experience long wait times in the emergency department before receiving their first dose of analgesia. This delay results from the complexities of the emergency care system. Using the intranasal or sublingual approach to administering analgesia to SCD patients with VOC offers a fast, safe, noninvasive, atraumatic, and easily accessible route of administration which could reduce the time to first dose of analgesia. With the evolving advances in the development and delivery of analgesic medications, providers should be conversant with the nuances of intranasal and sublingual analgesia in the management of acute vaso-occlusive pain crisis. This review explores the pharmacokinetic profiles, dosages, and administration of intranasal and sublingual analgesics with relevance to the SCD population.

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“…Although morphine is the most common opioid, morphine can induce a variety of adverse events, such as vomiting, itching, nausea, drowsiness, urinary retention, constipation and respiratory depression. In contrast, sufentanil is another μ-opioid agonist, which has been commonly used in pediatric and adult patients as an auxiliary drug in anesthesia for decades to treat moderate to severe pain [ 11 ]. Due to the high lipophilic properties, sufentanil has a rapid onset and offset time after intravenous injection, with a half-life of about 15 min [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Pain management of nalbuphine and sufentanil in patients admitted intensive care unit of different ages

Gong

Luan

et al. 2022

BMC Emerg Med

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Background Pain relief for patients in the intensive care unit (ICU) can improve treatment outcomes and reduce the burden on doctors and nurses. This study aims to report the clinical analgesic and sedative effects of nalbuphine and sufentanil on ICU patients. Methods This study retrospectively analyzed the medical records of 87 critically ill patients who received nalbuphine or sufentanil infusion in the ICU, including demographic data, diagnosis, Acute Physiology and Chronic Health Evaluation (APACHE) II, Critical Care Pain Observation Tool (CPOT), Richmond Agitation-Sedation Scale (RASS), systolic and diastolic blood pressure, heart rate and blood oxygen saturation (SpO2). The primary outcomes of this study were CPOT and RASS scores. The secondary outcomes were hemodynamic changes, including systolic blood pressure, diastolic blood pressure, heart rate, and SpO2. The adverse events recorded during pain management, such as hypoxemia, respiration depression and bradycardia, were also collected and analyzed. Results None of the patients in both groups experienced episode of hypoxemia, respiration depression and bradycardia. However, age-stratified analyses showed that nalbuphine has a better analgesic effect than sufentanil for patients aged ≤ 60 (P < 0.05). In contrast, sufentanil showed a better analgesic effect than nalbuphine for patients aged > 60 ( P < 0.05). Furthermore, nalbuphine has a significantly better sedative effect than sufentanil for patients aged ≤ 60 (P < 0.05). Conclusion ICU patients of different age groups may be suitable for different analgesics. For patients under the age of 60, nalbuphine has better analgesia and sedation than sufentanil, and does not cause respiratory depression and drastic hemodynamic changes.

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An up-to-date overview of sublingual sufentanil for the treatment of moderate to severe pain

Cited by 13 publications

References 43 publications

A retrospective analysis of the effects of different analgesics on the pain of patients with traumatic thoracolumbar fractures in the peri-treatment period

A retrospective analysis of the effects of different analgesics on the pain of patients with traumatic thoracolumbar fractures in the peri-treatment period

Improving the Emergency Department Management of Sickle Cell Vaso-Occlusive Pain Crisis: The Role and Options of Sublingual and Intranasally Administered Analgesia

Pain management of nalbuphine and sufentanil in patients admitted intensive care unit of different ages

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