An update of the aetiological factors involved in molar incisor hypomineralisation (MIH): a systematic review and meta-analysis

Garot, Elsa; Rouas, Patrick; Somani, C; Gd, Taylor; Wong, F.S.L.; Lygidakis, N. A.

doi:10.1007/s40368-021-00646-x

Cited by 109 publications

(132 citation statements)

References 68 publications

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“…This finding is in contrast with that reported in a previous systematic review and meta-analysis (Fatturi et al 2019). A similar conclusion was observed in relation to the positive effect of caesarean section (Garot et al 2021), as it appeared not to be associated with MIH in the previous systematic review (Fatturi et al 2019). The most recent review included 17 studies (n = 10,886 participants) and indicated that caesarean section increased the possibility of having MIH (OR 1.45; 95% CI 1.09-1.93; P = 0.01) (Garot et al 2021).…”

Section: Systemic and Medical Aetiological Factors A Prenatal Periodcontrasting

confidence: 78%

“…However, what constituted as maternal illnesses differed substantially among the studies and most were determined retrospectively from interviewing the mother, thus introducing a recall bias. In the perinatal period, different parameters, such as hypoxia, premature birth, low birth weight, birth complications and caesarean section, presenting alone or in combination, appear to be associated with the presence of MIH (Garot et al 2021). This recent systematic review and metaanalysis demonstrated that hypoxia at birth, reported in 16 studies (n = 9867 participants), substantially increased the possibility of having MIH (OR 2.76 [2.09,3.64]; P < 0.0001) (Garot et al 2021).…”

Section: Systemic and Medical Aetiological Factors A Prenatal Periodmentioning

confidence: 99%

“…GRADE quality of evidence of included studies related to aetiology a Studies with large number of examined children where (regardless the low quality of evidence resulting from the retrospective methodology) the meta-analysis revealed odds ratios indicating increased risk of having MIH(Garot et al 2021). …”

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confidence: 99%

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Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document

Lygidakis

Garot

Somani

et al. 2021

Eur Arch Paediatr Dent

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183

192

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Aim To update the existing European Academy of Paediatric Dentistry (EAPD) 2010 policy document on the ‘Best Clinical Practice guidance for clinicians dealing with children presenting with Molar-Incisor-Hypomineralisation (MIH).’ Methods Experts, assigned the EAPD, worked on two different topics: (A) Aetiological factors involved in MIH, and (B) Treatment options for the clinical management of MIH. The group prepared two detailed systematic reviews of the existing literature relevant to the topics and following a consensus process produced the updated EAPD policy document on the ‘Best Clinical Practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH).’ The GRADE system was used to assess the quality of evidence regarding aetiology and treatment which was judged as HIGH, MODERATE, LOW or VERY LOW, while the GRADE criteria were used to indicate the strength of recommendation regarding treatment options as STRONG or WEAK/CONDITIONAL. Results (A) Regarding aetiology, it is confirmed that MIH has a multifactorial aetiology with the duration, strength and timing of occurrence of the aetiological factors being responsible for the variable clinical characteristics of the defect. Perinatal hypoxia, prematurity and other hypoxia related perinatal problems, including caesarean section, appear to increase the risk of having MIH, while certain infant and childhood illnesses are also linked with MIH. In addition, genetic predisposition and the role of epigenetic influences are becoming clearer following twin studies and genome and single-nucleotide polymorphisms analyses in patients and families. Missing genetic information might be the final key to truly understand MIH aetiology. (B) Regarding treatment options, composite restorations, preformed metal crowns and laboratory indirect restorations provide high success rates for the posterior teeth in appropriate cases, while scheduled extractions provide an established alternative option in severe cases. There is great need for further clinical and laboratory studies evaluating new materials and non-invasive/micro-invasive techniques for anterior teeth, especially when aesthetic and oral health related quality of life (OHRQoL) issues are concerned. Conclusions MIH has been studied more extensively in the last decade. Its aetiology follows the multifactorial model, involving systemic medical and genetic factors. Further focused laboratory research and prospective clinical studies are needed to elucidate any additional factors and refine the model. Successful preventive and treatment options have been studied and established. The appropriate choice depends on the severity of the defects and the age of the patient. EAPD encourages the use of all available treatment options, whilst in severe cases, scheduled extractions should be considered.

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Section: Systemic and Medical Aetiological Factors A Prenatal Periodcontrasting

confidence: 78%

Section: Systemic and Medical Aetiological Factors A Prenatal Periodmentioning

confidence: 99%

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Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document

Lygidakis

Garot

Somani

et al. 2021

Eur Arch Paediatr Dent

Self Cite

183

192

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“…4 The etiology of MIH is not clear yet, theories such as illness during pregnancy, premature or prolonged birth, childhood illness (in the first year of life) and others like vitamin D deficiency and Bisphenol A are being discussed. [5][6][7][8][9][10] MIH affected enamel differs both, morphologically and histologically in comparison to healthy enamel. 11 The enamel is characterized by decreased mechanical properties, mineral density and an increased protein content.…”

Section: Introductionmentioning

confidence: 99%

Dental Students’ Knowledge, Attitudes and Beliefs Regarding Molar Incisor Hypomineralization (MIH): A Survey in Vienna, Austria

Bekes¹,

Melichar²,

Stamm³

et al. 2021

JMDH

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Purpose: Molar incisor hypomineralization (MIH) is a frequently encountered dental condition worldwide. The aim of this study was to evaluate the knowledge of Austrian dental students about MIH. Methods: A validated paper-based survey was distributed among 100 final year dental students at the Medical University of Vienna to assess their knowledge, perception and believes regarding MIH. One hundred dental students at the University Dental Clinic of Vienna were included in the study. At the time of the survey, they were in their 11th or 12th semester (final year). Information about the knowledge on diagnosis and prevalence, and attitudes and beliefs around etiology and management was collected. Results: All students replied, 94 questionnaires could be included in the analysis (50% female). 98% of the students were familiar with MIH and 86% were aware with the clinical features of MIH. Only 13% reported clinical ability to identify MIH. Regarding the etiology of MIH, most of the students (69%) named "genetic factors" as the most frequent etiological factor. Conclusion: Dental students showed great interest in the topic of MIH, as the majority of all respondents were in favor of deepening their knowledge regarding this topic. The students should be offered opportunities to do this both during and after their studies.

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“…As MIH continues to pose a serious clinical challenge for both patients and dentists [ 8 – 10 ], it is necessary to probe the perception and knowledge of future dentists regarding its diagnosis and management. This study was therefore carried out to investigate the knowledge, attitudes, and beliefs of final-year Swiss dental students towards MIH.…”

Section: Introductionmentioning

confidence: 99%

Knowledge, attitudes, and beliefs regarding molar incisor hypomineralisation amongst Swiss dental students

et al. 2021

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Background Knowledge obtained at the undergraduate level regarding molar incisor hypomineralisation (MIH) has an impact on future practice of dentists and paediatric dentists. This cross-sectional study aimed to assess final-year dental students’ knowledge, attitudes and beliefs towards MIH in all Swiss universities. Methods A previously utilised survey (in both English and German) was distributed among final-year dental students in all Swiss dental schools (Basel, Bern, Geneva and Zurich). It probed students’ knowledge, attitudes and beliefs regarding the diagnosis, prevalence, aetiology, and management of MIH, and was structured in two parts: knowledge/perception and clinical application. The students’ responses were analysed statistically with descriptive statistics. Results 113 out of 133 final-year Swiss dental students took part in the study (85%). Nearly all students were familiar with MIH (99%), but only 12% of them felt confident when diagnosing MIH clinically. Direct composite fillings (66%), indirect restorations (28%) and preformed stainless-steel crowns (26%) were chosen as most suitable treatment options for MIH-affected teeth. Conclusion Final-year Swiss dental students are well informed about MIH. However, they report low level of confidence when clinically confronted with MIH-affected teeth regarding its diagnosis and treatment. Swiss Universities curricula should be revisited accordingly.

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An update of the aetiological factors involved in molar incisor hypomineralisation (MIH): a systematic review and meta-analysis

Cited by 109 publications

References 68 publications

Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document

Best clinical practice guidance for clinicians dealing with children presenting with molar-incisor-hypomineralisation (MIH): an updated European Academy of Paediatric Dentistry policy document

Dental Students’ Knowledge, Attitudes and Beliefs Regarding Molar Incisor Hypomineralization (MIH): A Survey in Vienna, Austria

Knowledge, attitudes, and beliefs regarding molar incisor hypomineralisation amongst Swiss dental students

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