An update on biomarkers of bone turnover and their utility in biomedical research and clinical practice

Leeming, D.J.; Alexandersen, Peter; Karsdal, Morten A.; Qvist, Per; Schaller, Sophie; Tankó, László B.

doi:10.1007/s00228-006-0174-3

Cited by 149 publications

(146 citation statements)

References 93 publications

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“…However, no associations between bone markers and vBMAD spine and vBMAD neck in patients and controls were shown in our study, as also previously reported in healthy children and adolescents (20). Generally, bone markers are known to be related to changes in bone remodeling and in bone mass in elderly postmenopausal women (23,25) but not in young premenopausal women (28). Studies of the association between markers of bone turnover and subsequent bone gain in healthy girls have shown conflicting results (15,17,22,29).…”

Section: Rett Syndrome and Low Bone Turnovercontrasting

confidence: 51%

“…After a recent fracture bone markers will be increased, but neither patients nor controls had recent fractures. Levels of bone markers are known predictors of fracture risk in elderly, postmenopausal women (23,25), but the relation between bone markers and fractures in young premenopausal women (26), adolescents, and girls is not well known. Prospective studies are needed to The vBMAD spine or vBMAD neck levels had no influence on the ratio of bone marker levels in patients and controls through all ages.…”

Section: Rett Syndrome and Low Bone Turnovermentioning

confidence: 99%

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Low bone turnover phenotype in Rett syndrome: results of biochemical bone marker analysis

et al. 2013

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Background:Patients with Rett syndrome (RTT) are at risk of having low bone mass and low-energy fractures. Methods: We characterized bone metabolism by both bone formation and resorption markers in blood in a RTT population of 61 girls and women and 122 well-matched healthy controls. Levels of N-terminal propeptides of collagen type 1 (P1NP), C-terminal telopeptide cross links (CTX), osteocalcin (OC), and bone-specific alkaline phosphatase (B-ALP) were compared between RTT patients and controls in regression models adjusted for BMI, vitamin D status, volumetric bone mineral apparent density of the lumbar spine (vBMAD spine ), and femoral neck (vBMAD neck ). We examined biochemical bone marker levels overall and stratified to persons younger than age 25 y or equal to or older than age 25 y. results: The RTT patients had reduced levels of all biochemical bone markers (P < 0.05), which remained significant in persons younger than 25 y (P ≤ 0.001) regarding P1NP, CTX, and OC. Bone marker levels were not significantly associated to methyl-CpG-binding protein 2 (MECP2) mutation group, walking ability, or previous low-energy fractures. conclusion: Our findings of a low bone turnover state in girls with RTT suggest critical attention to medical treatment of low bone mass in young RTT patients.

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Section: Rett Syndrome and Low Bone Turnovercontrasting

confidence: 51%

Section: Rett Syndrome and Low Bone Turnovermentioning

confidence: 99%

Low bone turnover phenotype in Rett syndrome: results of biochemical bone marker analysis

et al. 2013

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“…In contrast, each biochemical marker reflects only one process (either bone resorption or formation). Mathematically combining these biochemical markers into a single quantitative measure of net BMB has not been and may not be possible, because neither marker can be quantitatively related to the rate of the process that it measures, let alone to the other marker (23,24). The application and interpretation of biochemical markers are also confounded by high interlaboratory analytical variability (25).…”

Section: Datamentioning

confidence: 99%

Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes

Morgan

Skulan

Gordon

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

121

104

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The ability to rapidly detect changes in bone mineral balance (BMB) would be of great value in the early diagnosis and evaluation of therapies for metabolic bone diseases such as osteoporosis and some cancers. However, measurements of BMB are hampered by difficulties with using biochemical markers to quantify the relative rates of bone resorption and formation and the need to wait months to years for altered BMB to produce changes in bone mineral density large enough to resolve by X-ray densitometry. We show here that, in humans, the natural abundances of Ca isotopes in urine change rapidly in response to changes in BMB. In a bed rest experiment, use of high-precision isotope ratio MS allowed the onset of bone loss to be detected in Ca isotope data after about 1 wk, long before bone mineral density has changed enough to be detectable with densitometry. The physiological basis of the relationship between Ca isotopes and BMB is sufficiently understood to allow quantitative translation of changes in Ca isotope abundances to changes in bone mineral density using a simple model. The rate of change of bone mineral density inferred from Ca isotopes is consistent with the rate observed by densitometry in long-term bed rest studies. Ca isotopic analysis provides a powerful way to monitor bone loss, potentially making it possible to diagnose metabolic bone disease and track the impact of treatments more effectively than is currently possible.osteopenia | biomarker | medical geology | biosignature | spaceflight

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“…The BTMs are proteins which indicate bone metabolism (Sousa et al 2014b), and are generally divided into collagenous bone formation markers, bone resorption markers and osteoclast regulatory protein markers (Leeming et al 2006). Analysis of BTMs might supply information in a fast, effective, sensitive, specific, and low cost manner (Allen 2003).…”

Section: Introductionmentioning

confidence: 99%

Bone turnover markers in sheep and goat: A review of the scientific literature

Camassa

Diogo

Sousa

et al. 2017

An. Acad. Bras. Ciênc.

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Bone turnover markers (BTMs) are product of bone cell activity and are generally divided in bone formation and bone resorption markers. The purpose of this review was to structure the available information on the use of BTMs in studies on small ruminants, especially for monitoring their variations related to diet, exercise, gestation and metabolic lactation state, circadian and seasonal variations, and also during skeletal growth. Pre-clinical and translational studies using BTMs with sheep and goats as animal models in orthopaedic research studies to help in the evaluation of the fracture healing process and osteoporosis research are also described in this review. The available information from the reviewed studies was systematically organized in order to highlight the most promising BTMs in small ruminant research, as well as provide a wide view of the use of sheep and goat as animal models in orthopaedic research, type of markers and commercial assay kits with cross-reactivity in sheep and goat, method of sample and storage of serum and urine for bone turnover markers determination and the usefulness and limitations of bone turnover markers in the different studies, therefore an effective tool for researchers that seek answers to different questions while using BTMs in small ruminants.

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An update on biomarkers of bone turnover and their utility in biomedical research and clinical practice

Cited by 149 publications

References 93 publications

Low bone turnover phenotype in Rett syndrome: results of biochemical bone marker analysis

Low bone turnover phenotype in Rett syndrome: results of biochemical bone marker analysis

Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes

Bone turnover markers in sheep and goat: A review of the scientific literature

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