An update on peripheral ossifying fibroma: case report and literature review

Abstract

The purpose of the present article was to present a clinical case of an 11-year-old girl with peripheral ossifying fibroma (POF). Additionally, after performing a literature review, we identified clinical information that occurs more frequently in association with POF, such evidence would help professionals in yielding a specific diagnosis and tailor a more specific therapeutic approach with the objective to decrease morbidities' associated with POF. This lesion represents the third most common lesion of all localized reactive hyperplastic lesions. Clinical aspects related to this pathology include the fact that it occurs most frequently in women between the first and second decades of life. It affects anterior maxillary region and interferes with normal functioning of this anatomical structure. After conducting the literature search, we found that it can also be presented in a considerable number of males with pain and hyperemia being the most common clinical manifestations. We found that often clinical cases are presented with incomplete information. It is important that in order to get to a consensus with respect to updates about information related to this lesion, new case series that include complete clinical information, radiographic analysis, and histopathology tests could be presented.

Peripheral Exophytic Oral Lesions: A Clinical Decision Tree

“…It represents 2% to 9% of all gingival lesions and 3% of all oral lesion biopsy samples [12, 13]. The lesion appears as a smooth, pedunculated, or sessile, firm to hard mass that usually emanates from the interdental papilla.…”

“…Tooth mobility, tooth migration, and bone destruction have been noticed in some cases [13]. This lesion occurs exclusively on the gingivae with up to 60% of cases being reported in the anterior areas of the maxilla (incisor-cuspid region) [12, 13]. Two theories have been proposed to explain the pathogenesis of the lesion: it might originate from a calcified pyogenic granuloma, or it may arise from an overgrowth and proliferation of different components of connective tissue in the periodontium, but the main etiology is yet to be elucidated [12, 14].…”

“…This lesion occurs exclusively on the gingivae with up to 60% of cases being reported in the anterior areas of the maxilla (incisor-cuspid region) [12, 13]. Two theories have been proposed to explain the pathogenesis of the lesion: it might originate from a calcified pyogenic granuloma, or it may arise from an overgrowth and proliferation of different components of connective tissue in the periodontium, but the main etiology is yet to be elucidated [12, 14]. Peripheral ossifying fibroma is predominantly a lesion of teenagers and young adults with a peak prevalence being between 10 to 19 years [10].…”

“…Peripheral ossifying fibroma is predominantly a lesion of teenagers and young adults with a peak prevalence being between 10 to 19 years [10]. Females are more affected than males, mainly during their second decade of life, due to fluctuations of estrogen and progesterone [12]. Treatment usually involves surgical excision, and the lesion should be excised down to the periosteum.…”

“…Treatment usually involves surgical excision, and the lesion should be excised down to the periosteum. The recurrence rate has been estimated to be between 8% and 20% [10, 12]. …”