An Update on Precancerous Lesions of Oral Cavity

Goyal, Deepak; Goyal, Pardeep; Singh, Harkanwal Preet; Verma, Chanchal

doi:10.18311/ijmds/2013/19825

Cited by 13 publications

(15 citation statements)

References 25 publications

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“…The main aim of the current study was to obtain epidemiological profile of OPMD and OSCC in the last 7 years in two districts of Karnataka to obtain a better estimate of total cases. [ 15 16 ] Based on our data, the prevalence of OPMD and OSCC in both districts might be linked to a rise in the usage of tobacco in various forms, areca nut and alcohol, compared to other districts. In addition, most of the OPMD cases were in the fourth decade similar to Misra et al [ 7 ] However, Scott and Cheah and Waldern and Shafer found most of their cases in sixth and seventh decades, respectively, which might be due to the cumulative effect of tobacco carcinogens.…”

Section: Discussionmentioning

confidence: 81%

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Epidemiological profile and clinical characteristics of oral potentially malignant disorders and oral squamous cell carcinoma: A pilot study in Bidar and Gulbarga Districts, Karnataka, India

Kumar

Abidullah

Elbadawi

et al. 2019

J Oral Maxillofac Pathol

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Section: Discussionmentioning

confidence: 81%

“…To achieve this goal, dentists play a pivotal role in educating the public, diagnosis and long-term follow-up of patients at risk and to avoid local recurrence and lymph node metastases. [ 8 9 14 15 16 ]…”

Section: Discussionmentioning

confidence: 99%

Epidemiological profile and clinical characteristics of oral potentially malignant disorders and oral squamous cell carcinoma: A pilot study in Bidar and Gulbarga Districts, Karnataka, India

Kumar

Abidullah

Elbadawi

et al. 2019

J Oral Maxillofac Pathol

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“…Similarly, in a study done by Pooja et al in 1999 to assess the role of serum iron, ferritin as well as total iron binding capacity (TIBC) in the pathogenesis and treatment planning of OSMF and Leukoplakia, showed that about 88% of patients with oral leukoplakia and OSMF (22) were males and 12% (03) were females. 10 The mean folate level with SD (ng/dl) was found to be 5. 12 Similarly, another study done by Guruprasad R et al to assess the serum vitamin C and iron levels in oral submucous fibrosis with 35 patients showed that iron levels was significantly decreased in OSMF patients than in controls.…”

Section: Discussionmentioning

confidence: 94%

Evaluation of Serum Iron and Folate Levels in Patients With Oral Leukoplakia

Pai

Maitra

2019

IJMBS

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Objectives To assess the levels of serum folate and iron in patients with and without any visible Oral leukoplakia. To correlate serum folate and iron levels and clinical staging of Oral leukoplakia. To correlate serum folate and iron levels and degree of dysplasia Materials & Methods: The study comprised of 102 patients (34 Oral leukoplakia patients with habit(s), 34 patients with habit(s) and no oral leukoplakia and 34 controls). The conditions were further clinically and histo-pathologically graded. Serum folate concentration was determined by chemi-luminescent immunoassay method from the serum (blood) sample without hemolysis and serum iron concentration was determined by photometric method. Results: The mean folate level ± SD (ng/dl) was found to be 5.17 ± 2.71 ng/dl, 5.29 ± 2.10 ng/dl and 5.37 ± 4.77 ng/dl in Oral leukoplakia patients, patients with habits without Oral leukoplakia and controls respectively. The mean iron level ± SD (μg/dl) was found to be 91.21 ± 28.73 μg/dl, 105.74 ± 33.20 μg/dl and 96.82 ± 38.92 μg/dl in Oral leukoplakia patients, patients with habits without Oral leukoplakia and controls respectively. Conclusion: In patients with habit and without leukoplakia and controls, there was a significant increase in the serum iron level than the oral leukoplakia patients. However, nosignificant differences seen in serum folate level in these three groups. Further studieswith larger sample size should be done to conclude serum folate and iron levels as adiagnostic marker in Oral leukoplakia. Keywords: Diagnosis, Serum folate, serum iron, potentially malignant disorders, potentially malignant disorders, Oral squamous cell carcinoma, malignant transformation, Immuno-assay.

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“…Collective estimate of annual rate of OL malignant transformation is 1.36% (95% confidence interval, 0.69–2.03%) in various populations and geographical areas. [ 1 ] The World Health Organization group has defined leukoplakia as “a white patch or plaque that cannot be characterized, clinically, or pathologically, as any other disease.”[ 2 ] Scarcely a few decades ago, a rare form of OL known as PVL was described, first by Hansen et al . in 1985.…”

Section: Discussionmentioning

confidence: 99%

“…A PMOL has been defined as a lesion or condition, in which risk of malignancy, being present at the time of initial diagnosis or at a future date. [ 2 3 ] Leukoplakia is the most common potentially malignant lesion of the oral mucosa and among all proliferative verrucous leukoplakia (PVL), distinct clinical form of oral leukoplakia (OL), is a rare potentially malignant oral mucosal disorder with a high rate of progression to oral SCC (OSCC) and verrucous carcinoma (VC). [ 4 ] The condition develops initially as focal clinical hyperkeratosis that progressively becomes a wide multifocal disease with gross exophytic features.…”

Section: Introductionmentioning

confidence: 99%

Diode laser: In treatment of recurrent verrucous leukoplakia

et al. 2016

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Laser first came into light in 1960 and had been used extensively in various fields of medicine. Laser has been experimented in the various dental field, and its utility is being recognized and established well in the dentistry. Lasers are widely used for a number of procedures such as cavity preparation, scaling, and root planning, surgical procedures like excision of soft tissue growths, etc., Improved healing, hemostasis, and sutureless excisions are some of the many advantages of laser over conventional treatment modalities. It is because of these advantages that laser is becoming more and more popular as a treatment option in various aspects of dentistry. We hereby present a case report, where we have used diode laser for surgical management of a proliferative verrucous leukoplakia (PVL), because of its many advantages over conventional methods. It presents very specific characteristics, mainly a more aggressive biological behavior than other forms of leukoplakia expressed by: A tendency toward multifocality (field cancerization); a high prospect of recurrence; and a high rate of malignant transformation, which can range between 40% and 100% in a follow-up period of 4.4–11.6 years. In this case, we evaluated the advantages of diode laser for the treatment of verrucous leukoplakia, where the results that we obtained were excellent. The patient had come for evaluation till the time of complete healing.

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An Update on Precancerous Lesions of Oral Cavity

Abstract: ABSTRACT

Cited by 13 publications

References 25 publications

Epidemiological profile and clinical characteristics of oral potentially malignant disorders and oral squamous cell carcinoma: A pilot study in Bidar and Gulbarga Districts, Karnataka, India

Epidemiological profile and clinical characteristics of oral potentially malignant disorders and oral squamous cell carcinoma: A pilot study in Bidar and Gulbarga Districts, Karnataka, India

Evaluation of Serum Iron and Folate Levels in Patients With Oral Leukoplakia

Diode laser: In treatment of recurrent verrucous leukoplakia

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