An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics

Durazzo, Alessandra; Nazhand, Amirhossein; Lucarini, Massimo; Atanasov, Atanas G.; Souto, Eliana B.; Novellino, Ettore; Capasso, Raffaele; Santini, Antonello

doi:10.3390/ijms21072285

Cited by 78 publications

(35 citation statements)

References 184 publications

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“…Environmentally, NMs are also applied for purification and desalination [25], as well as in water treatment and control, in treating the effects of air pollution and in reducing the time of degradation of plastic [26]. In addition, NMs can be applied in food processing and respective storage, and as nutraceutical matrices [27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Nanotoxicology and Nanosafety: Safety-by-Design and Testing at a Glance

Zielińska

Costa

Ferreira

et al. 2020

IJERPH

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146

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This review offers a systematic discussion about nanotoxicology and nanosafety associated with nanomaterials during manufacture and further biomedical applications. A detailed introduction on nanomaterials and their most frequently uses, followed by the critical risk aspects related to regulatory uses and commercialization, is provided. Moreover, the impact of nanotoxicology in research over the last decades is discussed, together with the currently available toxicological methods in cell cultures (in vitro) and in living organisms (in vivo). A special focus is given to inorganic nanoparticles such as titanium dioxide nanoparticles (TiO2NPs) and silver nanoparticles (AgNPs). In vitro and in vivo case studies for the selected nanoparticles are discussed. The final part of this work describes the significance of nano-security for both risk assessment and environmental nanosafety. “Safety-by-Design” is defined as a starting point consisting on the implementation of the principles of drug discovery and development. The concept “Safety-by-Design” appears to be a way to “ensure safety”, but the superficiality and the lack of articulation with which it is treated still raises many doubts. Although the approach of “Safety-by-Design” to the principles of drug development has helped in the assessment of the toxicity of nanomaterials, a combination of scientific efforts is constantly urgent to ensure the consistency of methods and processes. This will ensure that the quality of nanomaterials is controlled and their safe development is promoted. Safety issues are considered strategies for discovering novel toxicological-related mechanisms still needed to be promoted.

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Section: Introductionmentioning

confidence: 99%

Nanotoxicology and Nanosafety: Safety-by-Design and Testing at a Glance

Zielińska

Costa

Ferreira

et al. 2020

IJERPH

Self Cite

146

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“…This does not stop here, but nanotechnology has enabled progress to be made towards nanonutraceuticals, which have advantages due to their remarkable properties and versatility. Alternatively, nanonization strategies for probiotics and the usefulness of nanoprobiotics in releasing encapsulated bacteria and enhancing their absorption in the gastrointestinal tract are being explored, which may be of great interest in the treatment of allergies [ 112 ].…”

Section: Resultsmentioning

confidence: 99%

Probiotics as a Possible Strategy for the Prevention and Treatment of Allergies. A Narrative Review

López-Santamarina

Gonzalez

Lamas

et al. 2021

Foods

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Allergies are an increasing global public health concern, especially for children and people living in urban environments. Allergies impair the quality of life of those who suffer from them, and for this reason, alternatives for the treatment of allergic diseases or reduction in their symptoms are being sought. The main objective of this study was to compile the studies carried out on probiotics as a possible therapy for allergies. The most studied allergies on which probiotics have been shown to have a beneficial effect are rhinitis, asthma, and atopic dermatitis. Most studies have studied the administration of Lactobacillus and Bifidobacterium spp. in children and have shown beneficial effects, such as a reduction in hyperreactivity and inflammation caused by allergens and a decrease in cytokine release, among other beneficial effects. In the case of children, no clear beneficial effects were found in several studies, and the potential risk from the use of some opportunistic bacteria, such as probiotics, seems controversial. In the studies that reported beneficial results, these effects were found to make allergy symptoms less aggressive, thus reducing morbidity in allergy sufferers. The different effects of the same probiotic bacteria on different patients seem to reinforce the idea that the efficacy of probiotics is dependent on the microbial species or strain, its derived metabolites and byproducts, and the gut microbiota eubiosis of the patient. This study is relevant in the context of allergic diseases, as it provides a broader understanding of new alternatives for the treatment of allergies, both in children, who are the main sufferers, and adults, showing that probiotics, in some cases, reduce the symptoms and severity of such diseases.

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“…Recently several works remarked how the nanotechnologies open new triggering opportunities and challenges for functional foods development [144][145][146]. Particularly the current review of Durazzo et al [147] gives an updated overview on nanoprebiotics and nanoprobiotics.…”

Section: Discussionmentioning

confidence: 99%

Ready to Use Therapeutical Beverages: Focus on Functional Beverages Containing Probiotics, Prebiotics and Synbiotics

Nazhand

Souto

Lucarini³

et al. 2020

Beverages

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The growing global interest in functional foods containing nutrients capable of adding possible beneficial health effects is rapidly increasing both interest and consumer demand. In particular, functionalized beverages for their potential positive effect on health e.g., decreasing cholesterol level, lowering sugar, high fiber content, ability to enhance the immune system, and help digestion, have recently received special attention. Among the different beverages available on the market, probiotic dairy and non-dairy products have attracted much attention because of their affordable cost and their numerous therapeutic activities. Fermented milk and yogurt are currently worth €46 billion, with 77% of the market reported in Europe, North America, and Asia. Consumption of dairy beverages has some limitations due for example to lactose intolerance and allergy to milk proteins, thereby leading consumers to use non-dairy beverages such as fruit, grains, and vegetable juices to add probiotics to diet as well as driving the manufacturers to food matrices-based beverages containing probiotic cultures. The purpose of this review article is to evaluate the therapeutic performance and properties of dairy and non-dairy beverages in terms of probiotic, prebiotic, and synbiotic activities.

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An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics

Cited by 78 publications

References 184 publications

Nanotoxicology and Nanosafety: Safety-by-Design and Testing at a Glance

Nanotoxicology and Nanosafety: Safety-by-Design and Testing at a Glance

Probiotics as a Possible Strategy for the Prevention and Treatment of Allergies. A Narrative Review

Ready to Use Therapeutical Beverages: Focus on Functional Beverages Containing Probiotics, Prebiotics and Synbiotics

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