An Updated Review of Bioactive Peptides from Mushrooms in a Well-Defined Molecular Weight Range

Clemente, Angela; Pedone, Paolo V.; Ragucci, Sara; Maro, Antimo Di

doi:10.3390/toxins14020084

Cited by 38 publications

(25 citation statements)

References 82 publications

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“…The antioxidant compounds found in the fruiting bodies, the mycelium, and the mushroom culture can be phenolic acids, polysaccharides, tocopherols, flavonoids, carotenoids, glycosides, ergothioneine, and ascorbic acid [ 8 ]. Although the antioxidant activity of Pleurotus spp., also has been associated with some proteins/enzymes and peptides [ 62 ].…”

Section: Bioactive Compounds and Their Activitymentioning

confidence: 99%

Pleurotus Genus as a Potential Ingredient for Meat Products

Torres-Martínez

Vargas-Sánchez

Torrescano-Urrutia

et al. 2022

Foods

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Edible mushrooms are considered an important source of nutritional and bioactive compounds. In this review, the findings of macronutrients, bioactive compounds, antioxidant activity, and antimicrobials against foodborne pathogens of some Pleurotus spp., as well as their potential use as an ingredient in the meat industry are discussed. The results show that Pleurotus spp. are an important source of proteins and amino acids, carbohydrates, minerals, and vitamins. Additionally, the presence of some bioactive components, such as polysaccharides (α-glucans, β-glucans, and so on), proteins/enzymes and peptides (eryngin, pleurostrin, and others) phenolic acids (p-coumaric, chlorogenic, cinnamic, ferulic, gallic, protocatechuic, and others) and flavonoids (chrysin, naringenin, myricetin, quercetin, rutin, or the like) has been demonstrated. Several works evidenced the use of Pleurotus spp. in some meat and meat products (patties, sausages, paste, and suchlike) as a novel ingredient in order to improve their chemical composition and functional health promoting properties, as well as to increase their physicochemical and sensory attributes. In conclusion, the use of Pleurotus is a promissory strategy for the development of natural additives rich in nutritional and bioactive components for meat and meat product formulation.

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Section: Bioactive Compounds and Their Activitymentioning

confidence: 99%

Pleurotus Genus as a Potential Ingredient for Meat Products

Torres-Martínez

Vargas-Sánchez

Torrescano-Urrutia

et al. 2022

Foods

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“…Ribotoxin-like proteins (RL-Ps), which are enzymes possessing several interesting features, including antifungal activity, were found in various edible mushrooms [ 2 ]. Several peptides from edible mushrooms with numerous biotechnological activities, including antifungal activity, were also reported [ 3 ]. The biological activities of mushrooms received considerable interest due to a variety of health benefits, including immunomodulation, anti-cancer activity, cardiovascular therapies, and antiviral and antibacterial actions [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharides from Volvariella volvacea Mushroom: Extraction, Biological Activities and Cosmetic Efficacy

Sangthong

Pintathong

Pongsua

et al. 2022

JoF

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Polysaccharides from Volvariella volvacea (VVP) were investigated for their cosmetic-related activities and in vivo efficacy for use as a multifunctional active cosmetic ingredient. Three different polysaccharide extraction methods, including hot water shaking (HS), microwave-assisted (MA) and ultrasonic-assisted (UA), were used. Extractable yield, polysaccharide contents and biological activities, including antioxidant, anti-tyrosinase and anti-elastase activities, were compared. The polysaccharides from HS provided the highest extraction yield (15.58 ± 0.96% w/w) and the highest beta-glucan content (18.80 ± 0.81% w/w). The HS polysaccharides also possessed the highest inhibitory effects toward lipid peroxidation (IC50 of 0.0378 mg/mL), tyrosinase (51.46 mg KAE/g), and elastase (604.21 ± 73.66 mg EGCG/g). The cytotoxicity of the VVP was determined for safe use. A cosmetic gel cream containing VVP was developed and 0.2% VVP formulation was observed to be the most stable in color. UV protection factors, skin irritation by single patch test, and in vivo efficacy, including skin moisturization, anti-wrinkle and whitening, were measured. The VVP showed no cytotoxicity against human dermal skin fibroblast. The gel cream containing VVP provided less sun protection factor; however, it significantly exhibited the skin benefits of increasing moisture, gross elasticity, net elasticity, and skin firmness. Improvements to skin roughness, scaliness, wrinkles and in melanin content were also depicted gradually along 8 weeks. V. volvacea, therefore, could be a good source for polysaccharides being used as a moisturizing, anti-wrinkle, and whitening agent in cosmetic preparations.

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“…Mushrooms represent a significant source of natural bioactive peptides [ 1 ]. Indeed, in mushrooms not only bioactive peptides derived from protein fragmentation are present, but also small peptides, linear or cyclic, synthesized by mushrooms themselves [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Antamanide Analogs as Potential Inhibitors of Tyrosinase

Honisch¹,

Gazziero²,

Dallocchio³

et al. 2022

IJMS

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The tyrosinase enzyme, which catalyzes the hydroxylation of monophenols and the oxidation of o-diphenols, is typically involved in the synthesis of the dark product melanin starting from the amino acid tyrosine. Contributing to the browning of plant and fruit tissues and to the hyperpigmentation of the skin, leading to melasma or age spots, the research of possible tyrosinase inhibitors has attracted much interest in agri-food, cosmetic, and medicinal industries. In this study, we analyzed the capability of antamanide, a mushroom bioactive cyclic decapeptide, and some of its glycine derivatives, compared to that of pseudostellarin A, a known tyrosinase inhibitor, to hinder tyrosinase activity by using a spectrophotometric method. Additionally, computational docking studies were performed in order to elucidate the interactions occurring with the tyrosinase catalytic site. Our results show that antamanide did not exert any inhibitory activity. On the contrary, the three glycine derivatives AG9, AG6, and AOG9, which differ from each other by the position of a glycine that substitutes phenylalanine in the parent molecule, improving water solubility and flexibility, showed tyrosinase inhibition by spectrophotometric assays. Analytical data were confirmed by computational studies.

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An Updated Review of Bioactive Peptides from Mushrooms in a Well-Defined Molecular Weight Range

Cited by 38 publications

References 82 publications

Pleurotus Genus as a Potential Ingredient for Meat Products

Pleurotus Genus as a Potential Ingredient for Meat Products

Polysaccharides from Volvariella volvacea Mushroom: Extraction, Biological Activities and Cosmetic Efficacy

Antamanide Analogs as Potential Inhibitors of Tyrosinase

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