Polyoxometalates (POMs) are multi metallic and polyanionic oxides whose functionalization with organic moieties can generate new properties. Among possible strategies to generate molecular diversity and find applications in different fields, the postfunctionalization of a POM with peptides is particularly interesting and easily achievable. In this article, we present the functionalization of the Anderson‐Evans polyoxomolybdate ([MnMo6O24]3–) with a Bombesin antagonist peptide, to highlight the interplay between these 2 domains, in terms of structural changes and assembly. Moreover, since Bombesin analogs show a marked binding affinity and specificity for some subtypes of the Gastrin Releasing Peptide Receptor (GRP‐R), the impact of the peptide on the antitumor activity of the Anderson‐Evans polyoxomolybdate POM has been explored.

The introduction of a tailored hydrophilic/anionic spacer in an Anderson–Evans polyoxometalate, bis-conjugated with demobensin-1 peptide, fosters self-assembly into fibrillary nanostructures and an unprecedented cancer cell targeting ability.

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In recent years, cases of retinal toxicity occurred in some European, Middle Eastern, and South American countries following the use of perfluorocarbon liquids (PFCLs) on vitreoretinal surgeries owing to impurities in the product. Moreover, Spanish ophthalmologists reported several toxic cases on the use of perfluoro- n -octane Ala Octa (Alamedics, Dornstadt, Germany), raising the necessity of reviewing the current validated methods used for assessing the safety of PFCLs. We proved that in samples of PFCLs contaminated on purpose with impurities previously detected in Ala Octa devices, the determination of the so-called H-content using a 1 H NMR quantitative assay implemented with the electronic reference to access in vivo concentrations 2 technology failed to demonstrate a correlation between the H-content and in vitro cytotoxicity test in ARPE-19 and BALB 3T3 cell lines. Therefore, direct information on the safety of PFCLs was provided only by the cytotoxicity test in vitro validated according to ISO 10993-5, and the H-content was not predictive of perfluorocarbon ocular endotamponade cytotoxicity in vitro.

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