An Updated Review on Solid Lipid Nanoparticles

Vyawahare, Aman; Hakam, Nawaz; Gajbhiye, Kalpak; Patharkar, Swanand; Dosani, Faizan

doi:10.52711/0975-4377.2022.00008

RJPDFT

2022

DOI: 10.52711/0975-4377.2022.00008

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An Updated Review on Solid Lipid Nanoparticles

Aman Vyawahare¹,

Nawaz Hakam²,

Kalpak Gajbhiye³

et al.

Abstract: The aims of review are the latest research development of the lipid based carriers according to the recent relevant literatures. Each preparation of the lipid based Nanoparticles (SLMs) have advantages and disadvantages. The SLMs is an excellent drug delivery system and has broad prospects in the pharmaceutical field. This review discusses the advantages, therapeutic application of SLMs, various techniques of preparation, and different routes of administration, material use and characterization of solid lipid … Show more

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2023

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Cited by 4 publications

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Potential applications of Folate-conjugated Chitosan Nanoparticles for Targeted delivery of Anticancer drugs

Kumar Sarella,

Kumar Thammana

2023

RJPDFT

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Folate-conjugated chitosan nanoparticles represent a promising nanoplatform for targeted delivery of anticancer drugs. The nanoparticle carrier can protect the therapeutic agents from degradation and offer the ability to target cancer cells overexpressing folate receptors. This review summarizes recent research progress in synthesizing folate-conjugated chitosan nanoparticles as well as evaluating their potential as targeted drug delivery systems. The chemical conjugation of folic acid to chitosan is first discussed followed by an overview of different techniques for preparation of stable folate-conjugated chitosan nanoparticles less than 200 nm in size. Recent studies loading various anticancer drugs into these nanoparticles and investigating their in vitro cytotoxicity against multiple cancer cell lines are then summarized. The results indicate that folate-conjugated nanoparticles exhibit higher cytotoxicity and targeting efficiency compared to non-conjugated nanoparticles due to receptor-mediated endocytosis. Lastly, future challenges and opportunities are outlined including in vivo investigations to determine the effectiveness, toxicity, and pharmacokinetics of folate-conjugated chitosan nanoparticle systems as well as their potential clinical translation as targeted drug carriers for cancer chemotherapy.

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Potential applications of Folate-conjugated Chitosan Nanoparticles for Targeted delivery of Anticancer drugs

Kumar Sarella,

Kumar Thammana

2023

RJPDFT

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Method Development using a UV Visible Spectrophotometer for the Simultaneous Estimation of Rabeprazole, Aceclofenac and Paracetamol in Marketed Formulation

Ahmad¹,

Jawed²

2023

AJPA

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Rheumatoid arthritis, or RA, is an autoimmune and inflammatory disease, which means that your immune system attacks healthy cells in your body by mistake, causing inflammation (painful swelling) in the affected parts of the body. RA mainly attacks the joints, usually many joints at once. A complexation, derivatization, extraction, evaporation and sensitive-free direct a new, simple, precise, accurate, reproducible, and efficient UV spectrophotometric method is developed and validated for the simultaneous estimation of ternary mixture of rabeprazole, (MET) aceclofenac (SXG) and paracetamol (DGF) in both their bulk form and combined in tablet dosage form recently approved by FDA in 2019 to be used for treatment of Type 2 diabetes mellitus by simultaneous equation method. The solutions of standard and sample were prepared in methanol: water (80:20 v/v). The 𝜆max for MET, SXG, and DGF were 232.0, 212.0 and 272.0nm, respectively. Calibration curves are linear in the concentration ranges 10-50𝜇g/ml for MET, 1-5𝜇g/ml for SXG and 5-25𝜇g/ml for DGF, respectively. Results of analysis of simultaneous equation method were analyzed and validated for various parameters according to ICH guidelines.

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Comparison of Antifungal and Antimicrobial activities in different parts of Carica papaya Linn

Azam,

Rai,

Jawed

et al. 2023

AJPR

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Carica papaya plants used as a nutritious and medicinal purpose. Phytochemical analysis of Carica papaya leaf extract show all Phytochemical constituents such as saponin, flavonoid, glycoside, alkaloid, carbohydrate, tannins except steroids. The all extract subjected to systemic phytochemical screening for the presence of phytochemical constituents. Latex of papaya fruits shows significant activity against Candida albicans reported in the literature, well diffusion method shows stronger activity in methanol extract showing inhibition against in S. aureus than E. coli. It is used as Antifungal, Antibacterial, Anti-inflammatory, Antioxidant, Antidiabetic, wound healing and Analgesic activity etc.

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An Updated Review on Solid Lipid Nanoparticles

Cited by 4 publications

References 18 publications

Potential applications of Folate-conjugated Chitosan Nanoparticles for Targeted delivery of Anticancer drugs

Potential applications of Folate-conjugated Chitosan Nanoparticles for Targeted delivery of Anticancer drugs

Method Development using a UV Visible Spectrophotometer for the Simultaneous Estimation of Rabeprazole, Aceclofenac and Paracetamol in Marketed Formulation

Comparison of Antifungal and Antimicrobial activities in different parts of Carica papaya Linn

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