The present research was designed to evaluate matrix type Benidipine Hydrochloride transdermal patches. So, the present work is an attempt to study effect of variation in Methocel E15LV concentration and study effect of hydrophilic and hydrophobic Methocel E15LV and Eudragit RL100 combination on release profile of Benidipine Hydrochloride. All prepared formulations were evaluated for physical and mechanical properties like thickness, moisture uptake, percent flatness, tensile strength, and percent elongation. An attempt was made to get a patch with suitable drug release property as well as physical and mechanical properties. A formulation containing Methocel E15LV 2% has shown good physical, mechanical and in-vitro drug release properties. It also showed good diffusion of Benidipine Hydrochloride across goat skin.

The aims of review are the latest research development of the lipid based carriers according to the recent relevant literatures. Each preparation of the lipid based Nanoparticles (SLMs) have advantages and disadvantages. The SLMs is an excellent drug delivery system and has broad prospects in the pharmaceutical field. This review discusses the advantages, therapeutic application of SLMs, various techniques of preparation, and different routes of administration, material use and characterization of solid lipid Nanoparticles.

A rapid, sensitive and accurate method for Estimation of Anti- Histamine in Tablet Dosage Form by RP-HPLC. Mobile phase was Methanol: 0.1% Ortho phosphoric acid (80:20% v/v). Flow rate was 0.9 ml/min. The detection Wavelength was 227 nm. The injection volume was 20-µl. The proposed method was validated for selectivity, precision, linearity, and accuracy. All validation parameters were within the acceptable range. Linearity studies for Levamisole was performed (10-60µg/ml). The %RSD for accuracy found to be less than2%. Assay was found to be 99.17 to 101.65 respectively The range of 10-60µg /ml was selected for the linearity of a standard Levamisole. The 80%, 100% and 120% levels of recovery study were selected to perform the recovery study. Linearity studies for Levamisole was performed on (10-60µg /ml).

Literature survey reveals that few spectrophotometric, high performance liquid chromatographic (HPLC) and High Performance Thin Layer Chromatographic (HPTLC) methods were reported for the estimation of Flavoxate HCl in single and in combined dosage forms. But there is no any stability indicating UV spectroscopic study is reported for Flavoxate in single dosage form. So the present study was aimed to development of simple, accurate, rapid and economical UV-spectrophotometric stability indicating assay method were established for the determination of Flavoxate HCl in bulk and tablet formulation. The solvent was selected for stock solution preparation is water and required concentrations were prepared by using the same solvent. The λmax for detection of Flavoxate HCl is 211nm. In this method Flavoxate followed linearity in the concentrations of 1, 3, 5, 7, 9µg/ml with regression coefficient (r2) 0.999. The percent drug content was found to be 98.81±0.39 for FLV in tablet formulation. Recovery study results of FLV ranges from 99.11 to 100.49%. The method was found to be accurate and precise, as indicate by recovery studies as recoveries were close to 100% and %RSD is less than 2. Inter-day and intraday variation was found to be 0.75 and 0.45%, respectively. The LOD and LOQ values were found to be 0.719µg/ml and 2.186µg/ml, respectively. The stability study of Flavoxate was investigated when the drug was subjected to hydrolytic, peroxide, heat and photolytic (UV and sunlight) degradation. The results express that the Flavoxate is under thermal and photolytic (sunlight and UV light) conditions are more stable. In acidic, basic and hydrogen peroxide conditions Flavoxate is degraded in higher amount.

The current study was carried out in order to prepare sustain release multiparticulate drug delivery system of Ibuprofen which is also known as 2-(4-isobutylphenyl) propionic acid. From the drug excipient study it was found that the drug and polymer were compatible with each other and there was no disappearance, new formation of peaks on the FTIR study. From the DSC study it was seen that there was no change in the melting point of drug when mixed with the polymers. The method applied was Ionotropic gelation. The Microbeads were prepared by employing sodium alginate as a coating agent with HPMC as release retardant and calcium chloride as a cross linking agent. The prepared microbeads were evaluated for various parameters such as micromertics, loose surface crystal study, percentage yield, percent cumulative drug release and surface morphology. From the various evaluated parameters it was revealed that the prepared microbeads were having a good flow property. The percentage yield was found to be in the range of 65.23% - 79.45%, the drug release was found to be in the range of 4.96% - 96.08%. The batch of B7 was the optimized one as it contain higher amount of drug content and shows better amount of drug release then the other batches. The surface morphology study revealed that the optimized formulation was having small cracks or fractures on the surface. From the study we can conclude that this method can be employed for preparing microbeads of Ibuprofen without any difficulty and this formulation can utilized for reducing the dose frequency of Ibuprofen which will not hinder the GIT.