Formulation and Evaluation of Transdermal Patches of Benidipine Hydrochloride

Abstract

The present research was designed to evaluate matrix type Benidipine Hydrochloride transdermal patches. So, the present work is an attempt to study effect of variation in Methocel E15LV concentration and study effect of hydrophilic and hydrophobic Methocel E15LV and Eudragit RL100 combination on release profile of Benidipine Hydrochloride. All prepared formulations were evaluated for physical and mechanical properties like thickness, moisture uptake, percent flatness, tensile strength, and percent elongation. An attempt was made to get a patch with suitable drug release property as well as physical and mechanical properties. A formulation containing Methocel E15LV 2% has shown good physical, mechanical and in-vitro drug release properties. It also showed good diffusion of Benidipine Hydrochloride across goat skin.

Advancements of Polymer-Based Transdermal Drug Delivery Systems in Drug Bioavailability and Patient Compliance in United States

“…The drugs which are available in market and studied widely for the use of TDDS are nifedipine (Thacharodi et al, 1996), nitroglycerine, (Savoji et al, 2014;Wang et al, 1998) captopril, (Duraivel et al, 2014;Mohabe et al, 2011), chlorpheniramine (Gajbhiye et al, 2021), propranolol (Sirisha et al, 2012;Thacharodi & Rao, 1995), aspirin (Chorghe et al, 2013;Ammar et al, 2006), norethindrone (Barichello et al, 2006), hydrocortisone (Lashmar et al, 1994;Abruzzo et al, 2017), acyclovir (Zhao et al, 2006), fentanyl (Lashmar et al, 1994), theophylline (Akhtar et al, 2020;Zhao et al, 2006), nicotine (Akhtar et al, 2020;Zhao et al, 2006) etc. Detailed elaboration in Table 3.…”