An Updated Systematic Review and Meta-Analysis of the Efficacy of Vitamin D Food Fortification

Black, Lucinda J; Seamans, Kelly M.; Cashman, Kevin D.; Kiely, Máiréad

doi:10.3945/jn.112.158014

Cited by 194 publications

(167 citation statements)

References 38 publications

Supporting

Mentioning

160

Contrasting

Unclassified

Order By: Relevance

“…Thus, in a 12-week Finnish study carried out in forty-nine 65 to 85-year-old women, subjects with lower vitamin D status at baseline responded more efficiently to supplementation than those with more adequate status [29]. In a review and meta-analysis of 16 heterogeneous studies carried out around the world, the treatment effect of vitamin D3-fortified foods was substantially higher when mean baseline serum 25OHD was <50 rather than ≥50 nmol/L [30]. The design of our randomized controlled study was pre-specified to test this possible relationship.…”

Section: Relation To Initial Serum 25ohd Levelmentioning

confidence: 99%

Evolution of Serum 25OHD in Response to Vitamin D<sub>3</sub> Fortified-Yogurts Consumed by Healthy Menopausal Women: A Six-Month Randomized-Controlled Trial Assessing the Interactions between Doses, Baseline Vitamin D Status and Seasonality

Bonjour

Dontot-Payen²,

Rouy³

et al. 2017

Preprint

View full text Add to dashboard Cite

A 24 week-controlled trial was conducted in menopausal women (mean age:61.5) to assess serum 25-hydroyvitaminD (s25OHD) evolution in relation to three interdependent determinants: doses of supplemented (Suppl.) vitamin D3 (VitD3); baseline status; seasonality.Participants were randomized into 3 groups (Gr): Gr.Suppl.0, time-controls maintaining dietary habits; Gr.Suppl.5 and Gr.Suppl.10 consuming one and two 125 g servings of VitD3-fortified yogurts with 5 and 10 µg daily doses, respectively. The 16 intervention-weeks lasted from early-January to mid-August, the 8 follow-up-weeks from late-August to mid-October.Before enrollment, subjects were randomized into two s25OHD strata: "Low stratum (LoStr)": 25-50 nmol/L; "High stratum (HiStr)": >50-75 nmol/L. All enrolled participants remained compliant until study end: Gr.Suppl.0 (n=45), Gr.Suppl.5 (n=44) Gr.Suppl.10 (n=44). Over the 16 intervention and 8 follow-up weeks, s25OHD increased in both supplemented groups, more in Gr.Suppl.10 than Gr.Suppl.5. The constant rate of s25OHD per supplemental VitD3 microgram was greater in LoStr than HiStr. s25OHD increase was greater with late (mid-March) than early (mid-January) inclusion. In conclusion, this randomized trial demonstrates: -a dose-dependent s25OHD improvement related to fortified yogurt consumption; -an inversely baseline-dependent increase in s25OHD; -a seasonal effect that highlights the importance of vitamin D3 supplementation during winter, even at 5µg/d, in healthy menopausal women.KEY WORDS: nutritional intervention; menopausal women; vitamin D3-fortified yogurts; serum 25OHD dose response; seasonality interaction Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted:

show abstract

Section: Relation To Initial Serum 25ohd Levelmentioning

confidence: 99%

Evolution of Serum 25OHD in Response to Vitamin D<sub>3</sub> Fortified-Yogurts Consumed by Healthy Menopausal Women: A Six-Month Randomized-Controlled Trial Assessing the Interactions between Doses, Baseline Vitamin D Status and Seasonality

Bonjour

Dontot-Payen²,

Rouy³

et al. 2017

Preprint

View full text Add to dashboard Cite

show abstract

“…However, the selection of the definition becomes important in terms of devising strategies to bridge the gap between current intake (2- It has been emphasised and re-emphasised that there are only a limited number of public health strategies available to correct low dietary vitamin D intake, and these have been reviewed in detail elsewhere (9,17,49) , so only a brief overview will be provided here:…”

Section: Dietary Strategies For Increasing Vitamin D Intake and Statusmentioning

confidence: 99%

A review of vitamin D status and CVD

Cashman

2013

Proc. Nutr. Soc.

Self Cite

View full text Add to dashboard Cite

Beyond the well-accepted effects on the skeleton, low vitamin D status has been linked to increased risk of several non-skeletal disease, including CVD. If low serum 25-hydroxyvitamin D (25(OH)D) concentration is causally linked to risk of CVD then this is important not only because low vitamin D status is quite common particularly in winter in countries above 40°N, but also of key relevance is the fact that such low vitamin D status can be improved by food-based strategies. The overarching aim of the present paper is to review the current evidence-base to support a link between low vitamin D status and CVD risk. The review initially briefly overviews how mechanistically vitamin D may play a role in CVD and then reviews the current available evidence-base to support a link between low vitamin D status and CVD risk, with particular emphasis on data from the randomised control trials, cohort studies and recent meta-analysis data as well as to the conclusions of a number of authoritative agencies/bodies. Finally, the review summarises current serum 25(OH)D concentrations within a select number of adult populations in the context of different definitions of vitamin D status proposed recently, and then briefly highlights food-based strategies for increasing vitamin D intake and status. In conclusion, at present the data for a causal link between low vitamin D status and CVD are mixed and ambiguous; however, should causality be affirmed by ongoing and future studies, there are food-based strategies for enhanced vitamin D status in the population which could ultimately lower risk of CVD.

show abstract

“…In children the growth plate is open and produces cartilage to be mineralized, so this mineralization defect can leads to rickets (17,18). In adults the growth plate is closed and mineral levels in the skeleton are adequate to prevent deformity.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Vitamin D Deficiency in Nonspecific Musculoskeletal Pain

2015

View full text Add to dashboard Cite

Background: Vitamin D deficiency is common in all age groups throughout the world, and results in abnormalities in calcium, phosphorous and bone metabolism that can lead to muscle weakness, osteomalacia and osteopenia. Objectives: This study was designed to investigate the prevalence of vitamin D deficiency in patients with nonspecific pain for whom no specific causes such as trauma, infection, tumor, and inflammatory disorders could be identified. Patients and Methods:This cross-sectional study included 438 patients with nonspecific musculoskeletal pain seen at our clinic. After evaluating their vitamin D status, we treated two groups of patients: those with vitamin D deficiency (< 20 ng/mL) and those with insufficiency (20 -29 ng/mL). We treated our patients with 50,000 units of vitamin D every week for 6 -8 weeks. After treatment we evaluated pain relief of patient and level of 25 hydroxi vitamin D. Results: A total of 438 patients (52 men and 386 women) participated in the study. There was no statistically significant correlation between sex and symptoms. Deficiency was more frequent in females but the difference compared to males was not statistically significant. Approximately half of the patients (47%) comprised the vitamin D-deficient group. Most patients (86.5%) had insufficient or deficient levels (< 30 ng/mL) of vitamin D. The most prevalent vitamin D status in men was insufficiency, whereas the most prevalent status in women was deficiency. Spearman's correlation coefficient showed weak positive correlations between vitamin D status and the number of pregnancies (r = 0.14). More than 90% of our patients reported that pain and muscle weakness responded to treatment after 3 weeks. Conclusions: Because osteomalacia is a common cause of persistent, nonspecific musculoskeletal pain, screening all patients with these symptoms for hypovitaminosis D should be standard practice in clinical care.

show abstract

An Updated Systematic Review and Meta-Analysis of the Efficacy of Vitamin D Food Fortification

Cited by 194 publications

References 38 publications

Evolution of Serum 25OHD in Response to Vitamin D<sub>3</sub> Fortified-Yogurts Consumed by Healthy Menopausal Women: A Six-Month Randomized-Controlled Trial Assessing the Interactions between Doses, Baseline Vitamin D Status and Seasonality

Evolution of Serum 25OHD in Response to Vitamin D<sub>3</sub> Fortified-Yogurts Consumed by Healthy Menopausal Women: A Six-Month Randomized-Controlled Trial Assessing the Interactions between Doses, Baseline Vitamin D Status and Seasonality

A review of vitamin D status and CVD

Prevalence of Vitamin D Deficiency in Nonspecific Musculoskeletal Pain

Contact Info

Product

Resources

About