An updated view on the role of dopamine in myopia

Feldkaemper, Marita; Schaeffel, Frank

doi:10.1016/j.exer.2013.02.007

Cited by 325 publications

(276 citation statements)

References 121 publications

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“…3 In this study, the myopia induced in the D1R-KOVeh group was similar to that in the D1R-WT-Veh group. In contrast, the inhibition of myopia development by APO treatment in the D1R-WT group was largely lost in the D1R-KO-APO group.…”

Section: D1r-dependent Mechanism Of Apomorphine In Myopiasupporting

confidence: 49%

“…Previous pharmacologic manipulation showed that D1Rs play a role in axial eye growth, but the nature of that role is not clear. 3 Intravitreal injection of the D1R antagonist SCH 23390 enhanced FDM development in chickens. 49 Similarly, preliminary studies indicated the D1R agonist SKF 38393 inhibited FDM, whereas the D1R antagonist SCH 39166 enhanced FDM in mice (Zhou X, et al IOVS 2014;55:ARVO E-Abstract 3038).…”

Section: D1r-dependent Mechanism Of Apomorphine In Myopiamentioning

confidence: 99%

“…3,4 Retinal and vitreous dopamine and/or the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) levels are reduced during the development of FDM in various animals, including chickens, 5,6 monkeys, 7 and guinea pigs. 8 Furthermore, the decrease of retinal DOPAC was restricted only to the deprived area of the retina during partial deprivation.…”

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confidence: 99%

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Dopamine D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice

Huang

Zhang

Wang

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To determine the roles of dopamine D2 receptors (D2Rs) and dopamine D1 receptors (D1Rs) in the inhibition of form-deprivation myopia (FDM) by the nonselective dopamine agonist apomorphine (APO) in D2R-knockout (D2R-KO) and D1R-KO mice. METHODS.Retinal layer thicknesses and electroretinograms (ERGs) were analyzed in KO mice and in D2R and D1R antagonist-treated mice. D2R-KO or D1R-KO mice and wild-type (WT) littermates were subjected to form deprivation during postnatal weeks 5 to 8. Both groups were intraperitoneally injected daily with either APO (5 lg/g body weight) dissolved in 1 lg/ lL ascorbic acid or vehicle alone. Refraction, vitreous chamber depth (VCD), and axial length (AL), among other parameters, were measured prior to and at the end of the treatment period.RESULTS. The retinal layer thicknesses and ERGs in KO mice were similar to those treated with D2R and D1R antagonists. APO administration in WT mice inhibited the development of FDM by approximately 80%. FDM in D2R-KO mice was inhibited approximately 50% compared with WT mice and was further inhibited by APO to a level similar to that in APO-treated WT mice. FDM development in D1R-KO mice was similar to that in WT mice and was not affected by APO administration. The changes in VCD and AL were consistent with refraction data.CONCLUSIONS. In mice, APO-mediated FDM inhibition was abolished by D1R KO but not D2R KO. This indicates the specificity of D1Rs for the pharmacologic inhibitory effect of APO on FDM and a nonessential role of D2Rs in this process in mice.

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Section: D1r-dependent Mechanism Of Apomorphine In Myopiasupporting

confidence: 49%

Section: D1r-dependent Mechanism Of Apomorphine In Myopiamentioning

confidence: 99%

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Dopamine D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice

Huang

Zhang

Wang

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…Such an effect is tenable because a critical role for the D2R was described in contributing to the BL inhibitory effect on myopia development. 47 For example, intraocular injection of the D2R agonist quinpirole during a 3-hour dark period was sufficient to restore a light inhibitory effect on FDM, 25 whereas the D2R antagonist spiperone prevented the ocular growth inhibitory effect resulting from a brief period of normal unobstructed vision. 24 As was done to delineate the retinal cell type on which D1R activation by BL suppresses FDM, we are undertaking future studies to delineate the cell types on which D2R modulation by light in transgenic mouse strains.…”

Section: D1r (At Least Partially) Mediates Bl Inhibitory Effects On Rmentioning

confidence: 99%

Bright Light Suppresses Form-Deprivation Myopia Development With Activation of Dopamine D1 Receptor Signaling in the ON Pathway in Retina

Chen

Zhi

Ruan

et al. 2017

Invest. Ophthalmol. Vis. Sci.

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Citation: Chen S, Zhi Z, Ruan Q, et al. Bright light suppresses form-deprivation myopia development with activation of dopamine D1 receptor signaling in the ON pathway in retina. Invest Ophthalmol Vis Sci. 2017;58:230658: -231658: . DOI:10.1167 PURPOSE. To determine whether dopamine receptor D1 (D1R) signaling pathway activation by bright light (BL) in specific retinal neuronal cell types contributes to inhibiting formdeprivation myopia (FDM) in mice.METHODS. Mice (3-weeks old) were raised under either normal light (NL: 100-200 lux) or BL (2500-5000 lux) conditions with or without form deprivation. Refraction changes were evaluated with an eccentric infrared photorefractor, and ocular axial components with optical coherence tomography. The D1R antagonist, SCH39166, was intraperitoneally injected daily to evaluate if BL mediates declines in FDM development through D1R activation. Six different biomarkers of retinal neuronal types delineated differential distribution of D1R expression. cFos and phosphorylated tyrosine hydroxylase (p-TH) immunofluorescent staining evaluated D1R receptor activation and dopamine synthesis, respectively. CONCLUSIONS. Bright light increases D1R activity in the BCs of the ON pathway, which is associated with less myopic shift and ocular elongation than those occurring in NL. These declines suggest that increased D1R activity in the ON pathway contributes to the BL suppression of FDM development in mice.

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“…Outdoor activities have been proposed to reduce the risk of myopia progression via stimulation of dopamine release that is known to be able to reduce axial elongation [13,14]. Nonetheless, current studies have indicated that the effect is not clinically meaningful and further studies are required to clarify the value of this option [4].…”

Section: Outdoor Activitiesmentioning

confidence: 82%

The Current Management Strategies for Myopia Control in Children: Mini Review

Çan¹

2016

AOVS

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Purpose: To report a mini review on interventions for myopia control in children. Methods:A systematic review of the literature.Results: Peripheral defocus modifying bifocal contact lenses, orthokeratology and anti-muscarinic eye drop treatment are the most promising of common strategies for slowing the myopia progression with varying results. Additionally, outdoor activity has generally been recommended by eye care practitioners as a preventive simple strategy. Conclusion:A range of interventions can significantly reduce progression of myopia. To achieve the maximum control of myopia, it is very important to select the most effective treatment for the appropriate type of patient.

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An updated view on the role of dopamine in myopia

Cited by 325 publications

References 121 publications

Dopamine D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice

Dopamine D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice

Bright Light Suppresses Form-Deprivation Myopia Development With Activation of Dopamine D1 Receptor Signaling in the ON Pathway in Retina

The Current Management Strategies for Myopia Control in Children: Mini Review

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