Anacardium occidentale leaves extract and riboceine mitigate hyperglycemia through anti-oxidative effects and modulation of some selected genes associated with diabetes

Ukwenya, Victor Okoliko; Alese, Margaret Olutayo; Ogunlade, Babatunde; Folorunso, Ibukun Mary; Omotuyi, Olaposi Idowu

doi:10.1007/s40200-022-01165-2

Cited by 2 publications

(2 citation statements)

References 74 publications

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“…Only glomerulonephritis remains the first cause of end-stage renal disease. End-stage renal illness is frequently more challenging to treat than other kidney diseases due to its complicated metabolic abnormalities 11,12 . In order to delay diabetic nephropathy, prompt prophylaxis and treatment are therefore crucial 20,21 .…”

Section: Discussionmentioning

confidence: 99%

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Differential Expression of Prophetic Variables of Diagnostic Importance Having Potential Role in the Development of Diabetic Nephropathy

Malik¹,

Siddique²,

Parveen³

et al. 2023

PJMHS

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Introduction: Diabetes mellitus (DM), a metabolic syndrome with abnormality in metabolism of carbohydrates, protein and lipids, and characterized by absolute and relative deficiency of insulin secretion. DM leads to its most common and frequent complication- Diabetic kidney disease. Oxidative stress induced by decreased antioxidant defenses and/or increased free radical formation are involved in causative factor and disease in diabetics, is an evidence-based study. Materials and Methods: Place of Study: This studied group consisted of 100 subjects with diabetic nephropathy recruited from Jinnah hospital Lahore. Study Design: A comparative Clinical study. Objectives: The present study was designed to investigate the key processes involved in the development of diabetic nephropathy. Population size: total 100 patients were selected Data collection procedure: Five ml of venous blood sample was taken from the antecubital vein of each participant. The sample bottles were centrifuged within one hour of collection, after which the serum was separated and stored at -70°C until assayed. The subjects with the history of taking drugs (Including alcohol and cigarette), pre-diagnosis medications (e.g. antiparkinsonian/antipsychotic), were excluded from this study. Data Analysis Plan: Results were analyzed through T test by using SPSS version 16. Results: Hematological profile of diabetic nephropathy patients were observed. Abnormal changes were found in platelet count and lymphocytes predicting coagulation and inflammation inside body. Antioxidants (SOD, CAT, GSH-GPx) and vitamins (A, E, C, D) were decreased. Oxidative markers and inflammatory markers such as MDA, MPO, and AOPPs were found to be increased. Practical Implication: Present study will bring a positive change in the field of diabetology and will bring ease in the life of patients in the community . Conclusion: Owing to present facts it is clear that hyperglycemia activates the various signaling pathways and reactive oxygen species (ROS) formation, which further activates signaling cascades which causes the structural and functional alterations in kidney that enhance the complications associated with diabetic nephropathy. Keywords: Diabetic kidney disease, Oxidative stress, Reactive oxygen species, Antioxidants, AOPPs

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Section: Discussionmentioning

confidence: 99%

“…According to earlier research, oxidative stress is a significant factor contributing to diabetic nephropathy 8,9,11,12 . One of the main byproducts of membrane lipid peroxidation is malondialdehyde (MDA), and its formation might worsen membrane damage.…”

Section: Discussionmentioning

confidence: 99%

Differential Expression of Prophetic Variables of Diagnostic Importance Having Potential Role in the Development of Diabetic Nephropathy

Malik¹,

Siddique²,

Parveen³

et al. 2023

PJMHS

View full text Add to dashboard Cite

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Effect of Anacardium occidentale Leaf Powder on Growth Performance, Diarrhea Incidence, Blood Biochemistry, and Intestinal Traits in Weaned Piglets

Aroche,

Gao,

et al. 2024

Animals

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To evaluate the phytobiotic effect of Anacardium occidentale leaf powder (AOLP) on growth performance, diarrhea incidence, blood biochemistry, and intestinal traits, seventy-two weaned piglets were randomly distributed into four groups (six replicates/group and three pigs/replicate) for 28 days, receiving a control diet (T0) or being supplemented with 5 (T1), 10 (T2), or 15 (T3) g/kg of AOLP. The diets did not affect the growth performance (p > 0.05); however, the AOLP groups had a decreased diarrhea incidence and malondialdehyde concentration (p < 0.05; 28 days). However, the AOLP groups had increased immunoglobulins (G and M) and villus heights (p < 0.05) in the duodenum. Likewise, T3 improved the number of goblet cells in the villi and the whole intestine (p < 0.01), the Mucin2 area in the jejunum and ileum (p < 0.05), occludin gene expression in the jejunum (p < 0.01), and acetic and valeric acid production (p < 0.05). Microbial diversity at the genus level was not different (p > 0.05); however, T3 increased the abundance of the Lactobacillus genus. These findings suggest that dietary supplementation with AOLP improved intestinal health by increasing antioxidant, immune, anti-inflammatory, and antidiarrheal activity in the weaned piglets.

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Anacardium occidentale leaves extract and riboceine mitigate hyperglycemia through anti-oxidative effects and modulation of some selected genes associated with diabetes

Cited by 2 publications

References 74 publications

Differential Expression of Prophetic Variables of Diagnostic Importance Having Potential Role in the Development of Diabetic Nephropathy

Differential Expression of Prophetic Variables of Diagnostic Importance Having Potential Role in the Development of Diabetic Nephropathy

Effect of Anacardium occidentale Leaf Powder on Growth Performance, Diarrhea Incidence, Blood Biochemistry, and Intestinal Traits in Weaned Piglets

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