Anæmia and Low Serum-Copper During Zinc Therapy

Porter, K. G.; McMaster, D.; Elmes, Margaret E.; Love, A. H. G.

doi:10.1016/s0140-6736(77)90295-1

Cited by 101 publications

(47 citation statements)

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“…Furthermore, the Ca content of the supplement was low. Regarding a possible negative effect of Zn supplementation on Cu, or Fe (Porter et al, 1977;Lonnerdal, 1996) status or Ca supplementation on Mg status (Hallberg, 1998), we did not observe modifications in the supplemented group compared to the placebo group (Table 5). Our data suggest that a supplementation of micronutrients at nutritional levels does not induce alterations of micronutrient plasma level consecutively to possible interactions and confirm the previous findings of other interventional studies (Reddy & Cook, 1997;Hallberg, 1998;Whittaker, 1998).…”

Section: Discussionmentioning

confidence: 69%

Effects of a combined micronutrient supplementation on maternal biological status and newborn anthropometrics measurements: a randomized double-blind, placebo-controlled trial in apparently healthy pregnant women

et al. 2003

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Objective: To investigate the possible beneficial effects of a micronutrient supplementation to apparently healthy pregnant women on maternal biological status and new born anthropometric characteristics. Setting: Departments of Obstetric of the University Hospital of Grenoble (France) and Lyon (France), Laboratoire of Biology of Oxidative Stress, UFR de Pharmacie. Grenoble (France). Study design: Double-blind, randomized placebo-controlled intervention trial. Subjects: A total of 100 apparently healthy pregnant women were recruited at 1472 weeks of gestation to delivery. At the end, they were 65 women to follow out the study. Interventions: Daily consumption over gestation of a miconutrients supplement or placebo. Main outcome measures: Plasma micronutrient levels and oxidative stress parameters were measured in mothers at 14 and 38 weeks of gestation. New born's anthropometric characteristics were measured at delivery. Results: In the supplemented group, folic acid, vitamin C, E, B 2 , B 6 and b-carotene levels were higher than in the placebo group. Oxidative stress parameters were not different between the groups. Birth weights were increased by 10% and the number of low newborn weights (o2700g) decreased significantly when the mother received the supplementation. Maternal plasma Zn levels were positively correlated to the newborn heights. Conclusion: A regular intake of a micronutrient supplement at nutritional dose may be sufficient to improve micronutrient status of apparently healthy pregnant women and could prevent low birth weight of newborn. Sponsorship: The supplement and placebo were supplied and the study was partially funded by BOIRON Pharmaceutical Company.

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Section: Discussionmentioning

confidence: 69%

Effects of a combined micronutrient supplementation on maternal biological status and newborn anthropometrics measurements: a randomized double-blind, placebo-controlled trial in apparently healthy pregnant women

et al. 2003

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“…Similar effects have been seen in humans receiving long-term treatment with zinc (Porter et al 1977;Prasad et al 1978). However, no significant decreases in plasma copper levels were observed in humans receiving zinc for 6 weeks or 6 months (Henkin et al 1976;Samman and Roberts 1987) or in mice administered zinc for 1-12 weeks (Sutomo et al 1992).…”

Section: Health Effectsmentioning

confidence: 79%

“…At low doses (~0.7-0.9 mg zinc/kg/day) and intermediate exposure durations (6-13 weeks), the effect is minor and manifests as subclinical changes in copper-sensitive enzymes, such superoxide dismutase Fischer et al 1984;Milne et al 2001;. At higher exposure levels (~2 mg zinc/kg/day) for chronic duration, more severe symptoms of copper deficiency, including anemia, have been reported (Broun et al 1990;Gyorffy and Chan 1992;Hale et al 1988;Hoffman et al 1988;Patterson et al 1985;Porter et al 1977;Prasad et al 1978;Ramadurai et al 1993;Stroud 1991;Summerfield et al 1992). …”

Section: Oral Mrlsmentioning

confidence: 99%

“…The MRL was not based on a chronic-duration oral study due to a lack of adequate long-term studies in humans and animals. Several studies have reported copper deficiency-induced anemia resulting from longer-term exposure to zinc, either via supplements or other sources (Broun et al 1990;Gyorffy and Chan 1992;Hale et al 1988;Hoffman et al 1988;Patterson et al 1985;Porter et al 1977;Prasad et al 1978;Ramadurai et al 1993;Stroud 1991;Summerfield et al 1992); effects generally occurred at estimated exposure levels of approximately 2-10 mg zinc/kg/day. However, the available studies are limited by small numbers of subjects evaluated (often a single individual), limited evaluation of end points, and limited reporting of study results, making them unsuitable for use in the derivation of a chronic-duration MRL.…”

Section: Oral Mrlsmentioning

confidence: 99%

“…Long-term administration (1-8 years) of zinc supplements has caused anemia in humans (Broun et al 1990;Gyorffy and Chan 1992;Hale et al 1988;Hoffman et al 1988;Patterson et al 1985;Porter et al 1977;Prasad et al 1978;Ramadurai et al 1993;Salzman et al 2002;Stroud 1991;Summerfield et al 1992). Exposure of one patient to 2 mg zinc/kg/day as zinc sulfate for 10 months resulted in anemia (Hoffman et al 1988).…”

Section: Health Effectsmentioning

confidence: 99%

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