Anaemia in elderly patients with cancer: Focus on chemotherapy-induced anaemia

Ludwig, Heinz; Wedding, Ulrich; Belle, Simon Van

doi:10.1016/j.jgo.2012.02.006

Cited by 3 publications

(3 citation statements)

References 69 publications

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“…On the other hand, the distribution of the MCV values for the samples from anemic patients was more complex with side peaks at low and high MCV ranges ( Figure 4(b) ). Normocytic anemia, that is, with MCV values within 80–100 fL range, in the case of cancer patients is likely to be indicative of the bone marrow failure [ 3 ] and, depending on a variety of factors, including the type and intensity of chemotherapy, occurs in over 60% of cancer patients [ 18 – 20 ]. The bone marrow failure resulted in decreased production of functional RBCs and coupled with cancer related inflammatory response [ 18 ] and/or chemotherapy induced [ 19 , 20 ] increase in destruction of RBCs; blood loss leads to decrease in HGB, RBC count, and HCT.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Red Blood Cells with Multiwavelength Transmission Spectroscopy

Serebrennikova¹,

Huffman²,

García‐Rubio³

2015

BioMed Research International

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Multiwavelength transmission (MWT) spectroscopy was applied to the investigation of the morphological parameters and composition of red blood cells (RBCs). The MWT spectra were quantitatively analyzed with a Mie theory based interpretation model modified to incorporate the effects of the nonsphericity and orientation of RBCs. The MWT spectra of the healthy and anemic samples were investigated for the RBC indices in open and blinded studies. When MWT performance was evaluated against a standard reference system, very good agreement between two methods, with R 2 > 0.85 for all indices studied, was demonstrated. The RBC morphological parameters were used to characterize three types of anemia and to draw an association between RBC morphology and anemia severity. The MWT spectra of RBCs infected with malaria parasite Plasmodium falciparum at different life cycle stages were analyzed for RBC morphological parameters. The changes in the RBC volume, surface area, aspect ratio, and hemoglobin composition were used to trace the morphological and compositional alterations in the infected RBCs occurring with parasites' development and to provide insights into parasite-host interactions. The MWT method was shown to be reliable for determination of the RBC morphological parameters and to be valuable for identification of the RBC pathologic changes and disease states.

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Section: Resultsmentioning

confidence: 99%

Characterization of Red Blood Cells with Multiwavelength Transmission Spectroscopy

Serebrennikova¹,

Huffman²,

García‐Rubio³

2015

BioMed Research International

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“…It is predicted that by 2050, 80% of patients with cancer will fall into this age group. 69 A recent review has summarized current knowledge in this area, 70 and reported that CIA and fatigue management in elderly patients is not considered to be a high priority by oncologists. This is despite the fact that patients of all ages with CIA are likely to benefit equally from ESA treatment.…”

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confidence: 99%

“…This is despite the fact that patients of all ages with CIA are likely to benefit equally from ESA treatment. 70 Other studies currently underway will provide data on how best to individually tailor treatments towards specific patient groups. For example, the effectiveness and safety of DA treatment in patients with myelodysplastic syndromes will be better defined following results from a European, multicenter, double-blind, placebo-controlled study that is currently being conducted.…”

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confidence: 99%

Managing chemotherapy induced anemia with darbepoetin alfa and other erythropoiesis stimulating agents: a nurse's perspective

Derbyshire¹,

Thain²

2013

NRR

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Chemotherapy induced anemia (CIA) is a frequent complication of anticancer treatment, but often remains untreated. The main presenting symptom of CIA is fatigue, and this can have profound implications upon chemotherapy treatment compliance and patients' quality of life (QoL). Nevertheless, a tendency has been seen in both patients and physicians to underestimate the consequences of fatigue. As nurses are taking on greater responsibilities for identifying, monitoring, and in some cases even treating CIA, it is important that they have a clear understanding of the treatment options at their disposal. Erythropoiesis stimulating agents (ESAs) have been available as a tool for the treatment of CIA for many years. However, the vast majority of literature on this topic has been targeted towards physicians. Hence, the purpose of this review is to summarize the key ESA studies, with an emphasis on material that is of interest to the nursing community. Herein we present a brief chronological review of the development of ESAs to illustrate how the currently available treatment options for anemia arose. For conciseness, darbepoetin alfa (DA) has been used as a model to represent all ESAs; however, important findings from studies of other ESAs have also been included for completeness. We also discuss the management of CIA, based on the available literature and our experience of routine clinical practice in the UK. In conclusion, CIA is important in the context of maintaining QoL in patients undergoing chemotherapy and its effective management needs to be considered as part of their holistic care. Available studies show that ESA treatment can decrease fatigue levels and reduce the need for transfusions. ESAs, such as DA, may therefore be an important treatment option for patients with CIA. DA is well tolerated when used according to current recommendations, can be synchronized with chemotherapy cycles, and can also be self-administered.

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Chemotherapy-induced anemia: the story of darbepoetin alfa

Vansteenkiste

Wauters

Elliott

et al. 2013

Current Medical Research and Opinion

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As the past decade has broadened our knowledge on the benefits and risks of CIA management, continued high-quality studies will help to optimize treatment with ESAs in order to maximize quality of life for these patients. The limitation of a literature review of this nature is the complete reliance on previously published research and the availability of these studies using the methodology outlined above.

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Anaemia in elderly patients with cancer: Focus on chemotherapy-induced anaemia

Cited by 3 publications

References 69 publications

Characterization of Red Blood Cells with Multiwavelength Transmission Spectroscopy

Characterization of Red Blood Cells with Multiwavelength Transmission Spectroscopy

Managing chemotherapy induced anemia with darbepoetin alfa and other erythropoiesis stimulating agents: a nurse's perspective

Chemotherapy-induced anemia: the story of darbepoetin alfa

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Anaemia in elderly patients with cancer: Focus on chemotherapy-induced anaemia

Cited by 3 publications

References 69 publications

Characterization of Red Blood Cells with Multiwavelength Transmission Spectroscopy

Characterization of Red Blood Cells with Multiwavelength Transmission Spectroscopy

Managing chemotherapy induced anemia with darbepoetin alfa and other erythropoiesis stimulating agents: a nurse&#39;s perspective

Chemotherapy-induced anemia: the story of darbepoetin alfa

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Managing chemotherapy induced anemia with darbepoetin alfa and other erythropoiesis stimulating agents: a nurse's perspective