Anaerobic dechlorination and degradation of hexachlorocyclohexane isomers by anaerobic and facultative anaerobic bacteria

Jagnow, Gerhard; Haider, K.; Ellwardt, P. Chr.

doi:10.1007/bf00446454

Cited by 162 publications

(138 citation statements)

References 27 publications

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“…There are no reports as yet on the anaerobic degradation of the ε-isomer, but it is relatively unstable anyway. Isolates capable of degrading one or more of the other four HCH isomers under anaerobic conditions include Clostridium rectum (125), Clostridium sphenoides (58,84), Clostridium butyricum, Clostridium pasteurianum (64), Citrobacter freundii (64), Desulfovibrio gigas, Desulfovibrio africanus, Desulfococcus multivorans (21), and a Dehalobacter sp. (178).…”

Section: Anaerobic Degradationmentioning

confidence: 99%

Biochemistry of Microbial Degradation of Hexachlorocyclohexane and Prospects for Bioremediation

Lal

Pandey

Sharma

et al. 2010

Microbiol Mol Biol Rev

352

338

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SUMMARY Lindane, the γ-isomer of hexachlorocyclohexane (HCH), is a potent insecticide. Purified lindane or unpurified mixtures of this and α-, β-, and δ-isomers of HCH were widely used as commercial insecticides in the last half of the 20th century. Large dumps of unused HCH isomers now constitute a major hazard because of their long residence times in soil and high nontarget toxicities. The major pathway for the aerobic degradation of HCH isomers in soil is the Lin pathway, and variants of this pathway will degrade all four of the HCH isomers although only slowly. Sequence differences in the primary LinA and LinB enzymes in the pathway play a key role in determining their ability to degrade the different isomers. LinA is a dehydrochlorinase, but little is known of its biochemistry. LinB is a hydrolytic dechlorinase that has been heterologously expressed and crystallized, and there is some understanding of the sequence-structure-function relationships underlying its substrate specificity and kinetics, although there are also some significant anomalies. The kinetics of some LinB variants are reported to be slow even for their preferred isomers. It is important to develop a better understanding of the biochemistries of the LinA and LinB variants and to use that knowledge to build better variants, because field trials of some bioremediation strategies based on the Lin pathway have yielded promising results but would not yet achieve economic levels of remediation.

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Section: Anaerobic Degradationmentioning

confidence: 99%

Biochemistry of Microbial Degradation of Hexachlorocyclohexane and Prospects for Bioremediation

Lal

Pandey

Sharma

et al. 2010

Microbiol Mol Biol Rev

352

338

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“…All species formed ␥-tetrachlorocyclohexene as the main intermediate metabolite, and no ␥-pentachlorocyclohexene was observed. The mechanism of dechlorination in these enteric bacteria has not yet been characterized (142).…”

Section: Dehalogenation Reactionsmentioning

confidence: 99%

Biodegradation of Aromatic Compounds by Escherichia coli

Dı́az

Ferrández

Prieto

et al. 2001

Microbiol Mol Biol Rev

323

235

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Although Escherichia coli has long been recognized as the best-understood living organism, little was known about its abilities to use aromatic compounds as sole carbon and energy sources. This review gives an extensive overview of the current knowledge of the catabolism of aromatic compounds by E. coli. After giving a general overview of the aromatic compounds that E. coli strains encounter and mineralize in the different habitats that they colonize, we provide an up-to-date status report on the genes and proteins involved in the catabolism of such compounds, namely, several aromatic acids (phenylacetic acid, 3- and 4-hydroxyphenylacetic acid, phenylpropionic acid, 3-hydroxyphenylpropionic acid, and 3-hydroxycinnamic acid) and amines (phenylethylamine, tyramine, and dopamine). Other enzymatic activities acting on aromatic compounds in E. coli are also reviewed and evaluated. The review also reflects the present impact of genomic research and how the analysis of the whole E. coli genome reveals novel aromatic catabolic functions. Moreover, evolutionary considerations derived from sequence comparisons between the aromatic catabolic clusters of E. coli and homologous clusters from an increasing number of bacteria are also discussed. The recent progress in the understanding of the fundamentals that govern the degradation of aromatic compounds in E. coli makes this bacterium a very useful model system to decipher biochemical, genetic, evolutionary, and ecological aspects of the catabolism of such compounds. In the last part of the review, we discuss strategies and concepts to metabolically engineer E. coli to suit specific needs for biodegradation and biotransformation of aromatics and we provide several examples based on selected studies. Finally, conclusions derived from this review may serve as a lead for future research and applications

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“…HCH isomers have been found to persist in some environments for more than 15 years (Voerman & Besemer, 1970). Nevertheless, lindane biodegradation has been observed in both anaerobic and aerobic ecosystems (Bhuyan et al, 1992;Jagnow et al, 1977;Wada & Peel, 1989). Few bacterial isolates have been described as able to mineralize this compound.…”

mentioning

confidence: 99%

Rhodanobacter lindaniclasticus gen. nov., sp. nov., a lindane-degrading bacterium

Nalin

Simonet

Vogel³

et al. 1999

International Journal of Systematic and Evolutionary Microbiology

145

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Lindane-degrading activity under aerobic conditions has been observed in two bacterial strains : UT26, phenotypically identified as Sphingomonas paucimobilis, and a new single unidentified isolate named RP5557T. The rrs (165 rDNA) sequences for both strains and the phenotypic characteristics for the unidentified isolate RP5557T were determined. RP5557T does not have high identity (less than 90% in all cases) with any sequence in the GenBank or RDP databases. A phylogenetic analysis based on rrs sequences indicated that RP5557T belongs to the y-Proteobacteria in a coherent phylum that includes the genera Xanthomonas and Xy/e//a (1 00 O/ O bootstrap), whereas UT26 is clearly separate from the Xanthomonas cluster. Based on the phylogenetic analyses and on the phenotypic characteristics, a new genus, Rhodanobacter, containing a single species, Rhodanobacter lindaniclasticus, is proposed for strain RP5557T (= LMG 183853, which becomes the type strain.

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Anaerobic dechlorination and degradation of hexachlorocyclohexane isomers by anaerobic and facultative anaerobic bacteria

Cited by 162 publications

References 27 publications

Biochemistry of Microbial Degradation of Hexachlorocyclohexane and Prospects for Bioremediation

Biochemistry of Microbial Degradation of Hexachlorocyclohexane and Prospects for Bioremediation

Biodegradation of Aromatic Compounds by Escherichia coli

Rhodanobacter lindaniclasticus gen. nov., sp. nov., a lindane-degrading bacterium

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