Anaesthesia for a patient with beta thalassaemia major

Kallenbach, TF

doi:10.1080/22201181.2015.1076108

Cited by 3 publications

(7 citation statements)

References 18 publications

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“…Other novel treatment modalities include stem cell transplantation, bone marrow transfer, foetal haemoglobin inducers and gene therapy. 10…”

Section: Discussionmentioning

confidence: 99%

Perioperative management of thalassemia intermedia patient posted for major spine surgery – A case report

Jayaraman,

Sruthi K

2023

IJCA

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Thalassemia patients are known to have abnormal haemoglobin structure and function because of genetic suppression of chains in haemoglobin molecule. These tend to lead to abnormal coagulation pathway and can cause excessive bleeding in the intra operative period. Hence, thalassemia patients are difficult and often considered as high-risk patients. Vigilant monitoring, early diagnosis and prompt treatment plays a vital role in the management and improving patient outcomes. This case illustrates a successful T4-T8 laminectomy and excision of extradural lesion in a patient with Thalassemia intermedia, pointing out the pathophysiologic considerations and discussing the means to reduce the perioperative risk. There have only been a few reports in the literature for the same and hence this article is intended to provide an overview of the anaesthetic management for a patient with thalassemia, focussing specifically on the blood conservation strategy for major spine surgeries. The particularities described in this case report may help other anaesthesiologists choose the best strategy when facing challenging patients similar to the one described.

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“…Other novel treatment modalities include stem cell transplantation, bone marrow transfer, foetal haemoglobin inducers and gene therapy. 10…”

Section: Discussionmentioning

confidence: 99%

Perioperative management of thalassemia intermedia patient posted for major spine surgery – A case report

Jayaraman,

Sruthi K

2023

IJCA

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“…BTM is a severe form of disease with extramedullary hematopoiesis, hepatosplenomegaly, intravascular hemolysis, and growth retardation. 1,2 They often display an array of associated organ dysfunction that affects the risk of surgery and anesthesia, and most perioperative deaths occur due to cardiac complications. 1,2 They are also at increased risk of thromboembolic events that may be life-threatening at times.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 They often display an array of associated organ dysfunction that affects the risk of surgery and anesthesia, and most perioperative deaths occur due to cardiac complications. 1,2 They are also at increased risk of thromboembolic events that may be life-threatening at times. CVT is a neurological condition linked to hypercoagulable states.…”

Section: Discussionmentioning

confidence: 99%

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Anesthetic Management of a Child with β-Thalassemia Major and Cortical Venous Thrombosis

Tyagi

Dube

Rajagopalan

et al. 2020

J Neuroanaesth Crit Care

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Abstractβ-thalassemia are a group of inherited blood disorders with reduced hemoglobin levels. β-thalassemia major is the severe form of disease, and the patients often display an array of associated organ dysfunction which thus increase the risk associated with surgery and anesthesia. Patients with β-thalassemia major can have multiple pathological defects that may lead to thromboembolic events. Here, we report such a case who was complicated by occurrence of cerebral sinus thrombosis and presented for decompressive hemicraniectomy under general anesthesia. The anesthetic challenges during in such scenario have been discussed.

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“…T HALASSEMIA is mainly a combination of two Greek words, "Thalassa" meaning sea and "Hema" means blood [1]. Thalassemia is an inherited blood disorder that is commonly found in different parts of the world especially in South Asia.…”

Section: Introductionmentioning

confidence: 99%

Classification of β-Thalassemia Carriers From Red Blood Cell Indices Using Ensemble Classifier

et al. 2021

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Thalassemia is viewed as a prevalent inherited blood disease that has gotten exorbitant consideration in the field of medical research around the world. Inherited diseases have a high risk that children will get these diseases from their parents. If both the parents are β-Thalassemia carriers then there are 25% chances that each child will have β-Thalassemia intermediate or β-Thalassemia major, which in most of its cases leads to death. Prenatal screening after counseling of couples is an effective way to control β-Thalassemia. Generally, identification of the Thalassemia carriers is performed by some quantifiable blood traits determined effectively by high-performance-liquid-chromatography (HPLC) test, which is costly, time-consuming, and requires specialized equipment. However, cost-effective and rapid screening techniques need to be devised for this problem. This study aims to detect β-Thalassemia carriers by evaluating red blood cell indices from the complete-blood-count test. The present study included Punjab Thalassemia Prevention Project Lab Reports dataset. The proposed SGR-VC is an ensemble of three machine learning algorithms: Support Vector Machine, Gradient Boosting Machine, and Random Forest. Comparative analysis proved that the proposed ensemble model using all indices of red blood cells is very effective in β-Thalassemia carrier screening with 93% accuracy.

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Anaesthesia for a patient with beta thalassaemia major

Cited by 3 publications

References 18 publications

Perioperative management of thalassemia intermedia patient posted for major spine surgery – A case report

Perioperative management of thalassemia intermedia patient posted for major spine surgery – A case report

Anesthetic Management of a Child with β-Thalassemia Major and Cortical Venous Thrombosis

Classification of β-Thalassemia Carriers From Red Blood Cell Indices Using Ensemble Classifier

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