“…Overall, the weighted mean infusion rate for remifentanil (R) during maintenance of anaesthesia (from pre-bypass to end of surgery) varied between 1.29 (0.69) mg kg ±1 min ±1 pre-bypass; 1. 23 During tracheal intubation, more patients in the remifentanil group showed signs of inadequate anaesthesia compared with those in the fentanyl group (R 24%, F 9%, P<0.001). Response to sternal skin incision (R 11%, F 36%, P<0.001), sternotomy (R 14%, F 60%, P<0.001) and MSS (R 11%, F 52%, P<0.001) were signi®cantly and clinically less in the remifentanil group.…”