Anaesthetic technique may affect prognosis for ovarian serous adenocarcinoma: a retrospective analysis

Lin, Liping; Liu, C.; Tan, Hao; Ouyang, Han Dong; Zhang, Yanna; Zeng, Weian

doi:10.1093/bja/aer055

Cited by 164 publications

(84 citation statements)

References 33 publications

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“…Briefly, de Oliveira et al [11] demonstrated that only the use of combined intraoperative epidural-general analgesia followed by postoperative epidural analgesia (n = 26) was associated with better recurrence-free survival compared to either general anesthesia/intravenous analgesia (n = 127) or general anesthesia/postoperative epidural analgesia (n = 29). This is in agreement with Lin et al [25] who showed in 143 patients that surgery under epidural anesthesia/analgesia was more beneficial to patient survival than surgery under general anesthesia and postoperative intravenous opioid analgesia. The findings of these two studies highlight the importance of the intraoperative use of epidural anesthesia, which was associated at least in the work of de Oliveira et al [11] with less perioperative use of opioids.…”

Section: Postoperative Neuraxial Analgesia and Genitourologic And Gynsupporting

confidence: 92%

“…Six retrospective studies have addressed the question of whether regional analgesia, specifically neuraxial analgesia, has a significant impact on recurrence after genitourologic cancers [2,3,11,15,25,37] (Table 1). The results of three studies conducted in patients with prostate cancer are inconsistent [2,15,37].…”

Section: Postoperative Neuraxial Analgesia and Genitourologic And Gynmentioning

confidence: 99%

“…The results of the three retrospective studies in patients with ovarian cancer likewise differed importantly from one another [3,11,25]. Briefly, de Oliveira et al [11] demonstrated that only the use of combined intraoperative epidural-general analgesia followed by postoperative epidural analgesia (n = 26) was associated with better recurrence-free survival compared to either general anesthesia/intravenous analgesia (n = 127) or general anesthesia/postoperative epidural analgesia (n = 29).…”

Section: Postoperative Neuraxial Analgesia and Genitourologic And Gynmentioning

confidence: 99%

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Can Regional Anesthesia and Analgesia Prolong Cancer Survival After Orthopaedic Oncologic Surgery?

Cata

Hernandez

Lewis

et al. 2014

Clinical Orthopaedics &Amp; Related Research

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Background The perioperative period of major oncologic surgery is characterized by immunosuppression, angiogenesis, and an increased load of circulating malignant cells. It is a window period in which cancer cells may seed, invade, and proliferate. Thus, it has been hypothesized that the use of regional anesthesia with the goal of reducing surgical stress and opioid and volatile anesthetic consumption would avoid perioperative immune suppression and angiogenesis and ultimately cancer recurrence. Questions/purposes We performed a systematic review of the literature on the use of regional anesthesia and postoperative analgesia to improve cancer-related survival after oncologic surgery. Our primary topic of interest is survival after orthopaedic oncologic surgery, but because that literature is limited, we also have systematically reviewed the question of survival after breast, gastrointestinal, and genitourologic cancers.

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Section: Postoperative Neuraxial Analgesia and Genitourologic And Gynsupporting

confidence: 92%

Section: Postoperative Neuraxial Analgesia and Genitourologic And Gynmentioning

confidence: 99%

Section: Postoperative Neuraxial Analgesia and Genitourologic And Gynmentioning

confidence: 99%

See 1 more Smart Citation

Can Regional Anesthesia and Analgesia Prolong Cancer Survival After Orthopaedic Oncologic Surgery?

Cata

Hernandez

Lewis

et al. 2014

Clinical Orthopaedics &Amp; Related Research

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“…81 After adjusting for the other variables, it was found that the control group had a hazard ratio of 1.214 (P = 0.04), suggesting a beneficial effect of the epidural in this setting. The epidural consisted of a continuous infusion of 0.125% bupivacaine or 0.15% ropivacaine for 48 hours postoperatively.…”

Section: Positive Studiesmentioning

confidence: 91%

Do Amide Local Anesthetics Play a Therapeutic Role in the Perioperative Management of Cancer Patients?

Piegeler¹,

Hollmann

Borgeat

et al. 2016

International Anesthesiology Clinics

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“…Interest has been focused to local anesthesia (peripheral and central blocks), which has shown beneficial effects on immunity after surgery [147] and may affect surgical outcome of oncologic patients [43, [148][149][150]. Regional anesthesia is believed to be beneficial against cancer recurrence due to reduced exposure to immunosuppressive agents (i.e., nitrous oxide), reduced surgical stress and adrenergic stimulation, but the mechanism is still unclear [147].…”

Section: Does the Type Of Anesthesia Influence The Risk Of Cancer Recmentioning

confidence: 99%

Anesthesia, cytokines and cancer recurrence

Kitamura¹,

Biaso²,

Ingelmo

et al. 2015

Glob Anesth Perioper Med

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Cytokines are essential mediators for the regulation of both innate and acquired immunity and hematopoiesis. They modulate immune cell signaling, activation, adhesion and functioning. They regulate the individual response to several insults such as infection, inflammation, trauma, and pain. Moreover, the balance between pro-inflammatory and anti-inflammatory cytokines is critical for the evolution of surgical complications and tumor progression.Several drugs, including anesthetic agents, influence cytokines secretion. Opioids, inhalational agents, intravenous and local anesthetics have shown different effects on immune system and cytokine expression. Therefore, anesthesia may play an important role in postoperative recovery and outcome of cancer patients.The aim of the present article is to review the main role of some important cytokines and the effect of anesthesia techniques and drugs on their secretion. Furthermore, current clinical evidence regarding the effects of anesthesia on cancer recurrence will be discussed. Cytokines and immune systemCytokines are proteins expressed in both innate and acquired immune system and are often named according to the secreting cells (i.e., lymphocytes, interleukins, etc.). They are essential mediators of the natural (non-specific, innate) immunity, which is the initial step of the inflammatory response. They also play a pivotal role during the specific immunity, which occurs after exposure to antigens, as they regulate lymphocyte and leukocyte activation, growth and differentiation, and the immune-mediated inflammation [1].The cytokines have different structures, but also common aspects, which are summarized in Table 1.The aim of the present article is to review the main role of some important cytokines and the effect of anesthesia techniques and drugs on their secretion. Cytokines receptorsThe cytokines receptors are formed by one or more transmembrane proteins: the extracellular portion binds the cytokine, whereas the cytoplasmic part starts the signal cascade. Based on the extracellular portion, they are divided in five categories. 1) Type I receptors, which have four α-helical stands and contain four cysteine residues and the amino acid motif tryptophanserine-X-tryptophan-serine (WSXWS).2) Type II receptors, structurally similar to Type I receptors, but without the sequence WSXWS. Cytokines functionProvided that the same cytokine may be produced during both innate and acquired immunity response, cytokines can be classified according to their functions: 1)Cytokines regulating the innate immunity and secreted by stimulated macrophages; 2)Cytokines regulating the acquired immunity and secreted by lymphocytes; 3)Cytokines stimulating the hematopoiesiss and secreted by bone marrow, leucocytes and other cells. Common aspects of CytokineTheir secretion is brief and limited in time Cytokine expressed during the innate immunity response Tumor necrosis factor (TNF-α, TNF-β)The TNF is responsible for the initial phase of acute inflammatory response, especially against ...

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Anaesthetic technique may affect prognosis for ovarian serous adenocarcinoma: a retrospective analysis

Abstract: This retrospective analysis suggests that epidural anaesthesia and analgesia for ovarian serous adenocarcinoma surgery may reduce mortality during the initial years of follow-up.

Cited by 164 publications

References 33 publications

Can Regional Anesthesia and Analgesia Prolong Cancer Survival After Orthopaedic Oncologic Surgery?

Can Regional Anesthesia and Analgesia Prolong Cancer Survival After Orthopaedic Oncologic Surgery?

Do Amide Local Anesthetics Play a Therapeutic Role in the Perioperative Management of Cancer Patients?

Anesthesia, cytokines and cancer recurrence

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