Anal human papillomavirus prevalence and risk factors among men who have sex with men in Vietnam

Tuấn, Lê Anh; Prem, Kiesha; Pham, Quang Duy; Toh, Zheng Quan; Tran, Hau Phuc; Nguyen, Vuong; Ngọc, Chử Thị; Ly, Le Thi Khanh; Cao, Van; Le-Ha, Tam-Duong; Tuấn, Nguyễn Anh; Jit, Mark; Bright, Kathryn; Brisson, Marc; Nguyen, Thuong Vu; Garland, Suzanne M.; Anh, Đặng Đức; Trang, Nguyễn Vân; Mulholland, Kim

doi:10.1016/j.ijid.2021.09.016

Cited by 8 publications

(6 citation statements)

References 42 publications

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“…As men appear not to develop immunity to HPV following natural infection, the reinfected HPV type will likely depend on the prevalence of the individual HPV types circulating in the community. Studies have reported that the most common high-risk HPV type among HIV-negative MSM were HPV52, 58, 16, and 18 ( 5 , 6 , 21 – 24 ). Therefore, it is understandable that HPV types 58, 52, and 16 had the highest rates of reinfection in our study.…”

Section: Discussionmentioning

confidence: 99%

Reinfection of Nine-Valent Human Papillomavirus Vaccine Types Among HIV-Negative Men Who Have Sex With Men: A Prospective Cohort Study

Liu

Zhang

et al. 2022

Front. Public Health

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ObjectivesReinfection of human papillomavirus (HPV) among men who have sex with men (MSM) after clearing the infection of HPV has not been well characterized. To understand the reinfection of HPV among human immunodeficiency virus (HIV) negative MSM without HPV vaccine, we analyzed the reinfection of nine-valent HPV vaccine (9v-HPV) types.MethodsData were acquired from a prospective cohort study among HIV-negative MSM in Urumqi of Xinjiang from 1 April 2016 to 14 July 2020. Participants were recruited through a local non-government organization using a website advertisement. Self-administered questionnaires and self-collected anal swabs were collected at baseline and every 6 months. The incidence rates of reinfection was calculated based on the number of events divided by person-months of observation of event risk. 95% confidence intervals (CIs) were calculated based on the Poisson distribution.ResultsA total of 515 HIV-negative unvaccinated MSM were included with a mean age of 30.93 years (SD 7.85), and 27.68% were reinfected with any 9v-HPV type after clearance. The reinfection incidence rate of any 9v-HPV was 14.47 per 1000 person-months (95% CI: 11.52–17.87). HPV52 was the most common type of reinfection, with a reinfection rate of 17.96 per 1,000 person months (95% CI: 11.58–26.33). Univariate analysis showed that MSM over the age of 30 had a slightly higher risk of reinfection with any 9v-HPV (Hazard ratio (HR): 1.57; 95% CI: 1.01–2.45), but no significant association was observed in multivariate analysis.ConclusionsOur study showed MSM without HPV vaccine will become reinfected following the natural clearance of specific HPV types. It is also suggested that HPV vaccination is recommended not only prior to sexual debut but also after viral clearance for MSM to reduce HPV prevalence.

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Section: Discussionmentioning

confidence: 99%

Reinfection of Nine-Valent Human Papillomavirus Vaccine Types Among HIV-Negative Men Who Have Sex With Men: A Prospective Cohort Study

Liu

Zhang

et al. 2022

Front. Public Health

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“…HPV LabNet was used to validate HPV detection and genotyping using 40 study samples from each site: approximately 90% agreement was achieved between the laboratories, as previously reported. ( 18 )…”

Section: Methodsmentioning

confidence: 99%

Prevalence and risk factors for human papillomavirus infection among female sex workers in Hanoi and Ho Chi Minh City, Viet Nam: a cross-sectional study

Pham

Prem

Lê

et al. 2022

WPSAR

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Background: Female sex workers (FSWs) are at high risk of human papillomavirus (HPV) infections and cervical cancer due to their high number of sexual partners. The objectives of this study were to determine the prevalence of HPV and identify risk factors for high-risk HPV infection among FSWs in Hanoi and Ho Chi Minh City (HCMC), Viet Nam. Methods: A cross-sectional study was conducted in Hanoi and HCMC between December 2017 and May 2018. We surveyed and screened 699 FSWs aged >18 years for HPV infection and abnormal cytology. A multivariable modified Cox regression model was used to determine risk factors for high-risk HPV infection. Results: The overall prevalence of any HPV, high-risk HPV and HPV-16/18 infection in the 699 FSWs was 26.3%, 17.6% and 4.0%, respectively, and were similar in both cities. Multiple infections were identified in 127 participants (69.0%). HPV-52 was the most prevalent (7%), followed by HPV-58 (6%). Abnormal cytology was detected in 91 participants (13.0%). FSWs who are divorced (adjusted prevalence ratio [aPR]: 1.96, 95% confidence interval [CI]: 1.01–3.81), widowed (aPR: 3.26, 95% CI: 1.49–7.12) or living alone (aPR: 1.85, 95% CI: 1.01–3.39) were associated with a higher prevalence of high-risk HPV infection. Discussion: Almost one in five FSWs in Viet Nam are infected with high-risk HPV. This highlights the importance of prevention strategies such as HPV vaccination and screening in this high-risk group.

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“…In men and for other HPV+ cancers, there is still no validated method of diagnosis or screening, but papillomavirus has been detected in several samples: seminal fluid, phenocopy with acetic acid, urethral specimen, penile scrapings (taken from the crown of the glans of the penis, from the inner layer of the foreskin, from the body of the penis). Among the detection methods, Polymerase Chain Reaction (PCR) is the most widely used [100][101][102][103][104].…”

Section: Secondary Preventionmentioning

confidence: 99%

Human Papillomavirus Epidemiology and Prevention: Is There Still a Gender Gap?

Milano¹,

Guarducci²,

Nante³

et al. 2023

Preprint

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Background and aim: Human Papillomavirus (HPV) is sexually transmitted, one of the three most common sexually transmitted infections (STIs) in both males and females, and the most common viral STI. A crucial public health strategy to protect people against HPV is through vaccination, which has shown its effectiveness in preventing HPV related diseases. Presently three types of vaccines are available (bivalent, quadrivalent, and nonavalent) and they all target at least the two most oncogenic virus genotypes (HPV 16, 18). In the past few years, the need to implement vaccination programmes that include all genders has been discussed in order to achieve herd immunity against HPV. To date, only a few countries have included young males in their vaccination programmes, so we aim through this review to provide an overview of the epidemiology of HPV and prevention strategies to prevent it, reporting the latest findings from the scientific literature.

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Anal human papillomavirus prevalence and risk factors among men who have sex with men in Vietnam

Cited by 8 publications

References 42 publications

Reinfection of Nine-Valent Human Papillomavirus Vaccine Types Among HIV-Negative Men Who Have Sex With Men: A Prospective Cohort Study

Reinfection of Nine-Valent Human Papillomavirus Vaccine Types Among HIV-Negative Men Who Have Sex With Men: A Prospective Cohort Study

Prevalence and risk factors for human papillomavirus infection among female sex workers in Hanoi and Ho Chi Minh City, Viet Nam: a cross-sectional study

Human Papillomavirus Epidemiology and Prevention: Is There Still a Gender Gap?

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