Analgesia and ptosis caused by caerulein and cholecystokinin octapeptide (CCK-8)

Zetler, G.

doi:10.1016/0028-3908(80)90047-7

Cited by 208 publications

(34 citation statements)

References 25 publications

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“…Behavioral studies showed that systemic injection of C-terminal CCK octapeptide (CCK-8) caused analgesia, hypo thermia, potentiation of hexobarbital-induced sleep, sedation and an anticonvulsant effect in mice (2). CCK-8 also suppresses loco motor activity when administered centrally or peripherally (3-5).…”

Section: Cholecystokininmentioning

confidence: 99%

Effects of Cholecystokinin Tetra and Octa Peptides on Locomotor Activity in Mice

Takeda

Takáno

Kamiya

1986

Japanese Journal of Pharmacology

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Section: Cholecystokininmentioning

confidence: 99%

Effects of Cholecystokinin Tetra and Octa Peptides on Locomotor Activity in Mice

Takeda

Takáno

Kamiya

1986

Japanese Journal of Pharmacology

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“…It has been reported that ceruletide pos sesses a weak central depressant action (1,3,4). The slight but significant decrease in the response rate in the discrete avoidance response might reflect such an action of ceruletide.…”

mentioning

confidence: 92%

Effects of Ceruletide, Administered Singly and in Combination with Central-Acting Drugs, on Discrete Shuttle Avoidance Response in Mice

Kuribara¹,

Asami

Ida

et al. 1990

Japanese Journal of Pharmacology

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Abstract-The single administration of ceruletide at 10-300 '"g/kg, i.p., slightly but significantly decreased the response rate (frequency of shuttles) under a discrete avoidance task in mice. Over 10 ag/kg of ceruletide attenuated the increase in the response rate induced by methamphetamine (0.5 mg/kg, s.c.). However, ceruletide, at 1-300 ug/kg, did not significantly enhance the response and/or avoidance-decreasing effects of chlorpromazine (1 mg/kg, s.c.), haloperidol (0.1 mg/kg, s.c.), pilocarpine (4 mg/kg, s.c.) and N6-(L-2-phenylisopropyl)-adenosine (0.1 mg/kg, s.c.), but rather tended to reduce the avoidance-decreasing effect of chlorpromazine and pilocarpine at 1-100 fig/kg.

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“…It has been reported that CCK may control various physiological events (Zetler, 1985) including hypothermia (Katsuura et al, 1981), analgesia (Zetler, 1980;Kubota et al, 1985), sedation (Zetler, 1981) and satiety (Gibbs et al, 1973). Recent studies have also indicated a role of CCK in anxiety.…”

Section: Introductionmentioning

confidence: 99%

The behavioural properties of CI‐988, a selective cholecystokinin_B receptor antagonist

Singh¹,

Field²,

Hughes³

et al. 1991

British J Pharmacology

136

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1 The behavioural effects of a selective cholecystokininB (CCKB) receptor antagonist CI-988 were investigated in rodents. 2 In three rodent tests of anxiety (rat elevated X-maze, rat social interaction test and mouse light/dark box) CI-988 over the dose range 0.001-I0.Omgkg 1, (i.p.) produced an anxiolytic-like action. The magnitude of this effect was similar to that of chlordiazepoxide (CDP). In contrast, the selective CCKA receptor antagonist, devazepide, was inactive. CI-988 also showed anxiolytic-like action in the rat conflict test but the magnitude of this effect was about 2.5 fold less than that of CDP. 3 Central but not peripheral administration of the selective CCKB receptor agonist, pentagastrin, like FG 7142, produced an anxiogenic-like action. 4 The pentagastrin-induced anxiety was dose-dependently antagonized by CI-988, whereas devazepide was inactive. However, ten times higher doses of CI-988 were required to block a similar action of FG 7142. 5 In contrast to CDP, CI-988 up to 3000 fold higher doses than those inducing anxiolysis was inactive in tests measuring sedation and ataxia. It also failed to antagonize pentylenetetrazol-induced tonic seizures. Furthermore, CI-988 did not interact with alcohol or barbiturates. Thus, CI-988 appears to be an anxioselective compound. 6 The anxiolytic-like action of CDP in the rat elevated X-maze was dose-dependently antagonized by flumazenil. In contrast, the benzodiazepine receptor antagonist failed to block a similar effect of Thus, CI-988 shows anxiolytic-like activity in several animal models of anxiety. The anxiolytic-like effect of CI-988 involves a novel mechanism of action, that is likely to be mediated by selective antagonism of the brain CCKB receptor. It is suggested that CI-988 should have a better side-effect profile in man than the benzodiazepines.

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Analgesia and ptosis caused by caerulein and cholecystokinin octapeptide (CCK-8)

Cited by 208 publications

References 25 publications

Effects of Cholecystokinin Tetra and Octa Peptides on Locomotor Activity in Mice

Effects of Cholecystokinin Tetra and Octa Peptides on Locomotor Activity in Mice

Effects of Ceruletide, Administered Singly and in Combination with Central-Acting Drugs, on Discrete Shuttle Avoidance Response in Mice

The behavioural properties of CI‐988, a selective cholecystokinin_B receptor antagonist

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Analgesia and ptosis caused by caerulein and cholecystokinin octapeptide (CCK-8)

Cited by 208 publications

References 25 publications

Effects of Cholecystokinin Tetra and Octa Peptides on Locomotor Activity in Mice

Effects of Cholecystokinin Tetra and Octa Peptides on Locomotor Activity in Mice

Effects of Ceruletide, Administered Singly and in Combination with Central-Acting Drugs, on Discrete Shuttle Avoidance Response in Mice

The behavioural properties of CI‐988, a selective cholecystokininB receptor antagonist

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The behavioural properties of CI‐988, a selective cholecystokinin_B receptor antagonist