Analgesic activity of Cassia alata leaf extract and kaempferol 3-O-sophoroside

Palanichamy, S.; Nagarajan, S.

doi:10.1016/0378-8741(90)90099-f

Cited by 80 publications

(53 citation statements)

References 4 publications

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“…In Suriname, root extracts from C. alata are used for the treatment of uterus disorders [1]. Pharmacological investigations performed so far on C. alata have shown that this herb has several biological activities, such as antimicrobial [8,9], antifungal [2,10,11], purgative [4], anti-inflammatory [11,12], analgesic [1,11,13], antitumor [14], and hypoglycaemic [11] activities.…”

Section: Published In Final Edited Form Asmentioning

confidence: 99%

“…alata is one of the most important species of the genus Cassia which is rich in anthraquinones and polyphenols [13,15]. The leaves of C. alata have been qualitatively analyzed for the presence of primarily five pharmacologically active anthraquinones: rhein, aloe-emodin, chrysophanol, emodin, and physcion [16], as well as the flavonoid kaempferol [17].…”

Section: Published In Final Edited Form Asmentioning

confidence: 99%

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Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography

Fernand

Dinh

Washington

et al. 2008

Talanta

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A simple high performance liquid chromatography (HPLC) method was developed and validated for the determination of six phenolic compounds, five anthraquinones (rhein, aloe-emodin, emodin, chrysophanol and physcion) and a flavonoid (kaempferol), in root extracts from Cassia alata L. Solid-phase extraction, using C 18 cartridges, was used to remove interfering substances from the root extracts. The extracts were analyzed on a C 18 column using an isocratic mobile phase which consisted of acetonitrile, methanol, and 10 mM aqueous ammonium acetate (25: 55: 20, v/v). Identification of the analytes was performed by use of standards and on-line mass spectrometric detection using atmospheric pressure chemical ionization. The concentration of the phenolic compounds in the root extracts was determined using HPLC with ultraviolet detection at 260 nm. The limits of detection obtained for the anlytes were in the range of 0.23 -4.61 ppm. The overall R.S.D. precision values (intra and inter-day) for the retention times and peak-areas were lower than 0.16% and 2.10%, respectively. In addition, the recovery of the developed method for the analysis of these phenolic compounds was determined, and ranged from 81.2 ± 4.3% to 106 ± 2%.

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Section: Published In Final Edited Form Asmentioning

confidence: 99%

Section: Published In Final Edited Form Asmentioning

confidence: 99%

Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography

Fernand

Dinh

Washington

et al. 2008

Talanta

View full text Add to dashboard Cite

show abstract

“…The other uses of C. alata are as an antihelminthic, antibacterial, laxative, diuretic, for treatment of snakebites and uterine disorders (Kirtikar and Basu, 1975). Besides the leaf extract of this species has shown several pharmacological properties such as antimicrobial, antifungal (Khan et al, 2001), antiseptic (Esimone et al, 2008), anti-inflammatory, analgesic (Palanichamy and Nagarajan, 1990) and antihyperglycemic activities (Palanichamy et al, 1988). It contains therapeutic (Damodaran and Venkataraman, 1994) and anti-ageing activities (Pauly et al, 2002) also.…”

Section: Cassia Alata Lmentioning

confidence: 99%

Advances in Micropropagation of a Highly Important Cassia species- A Review

Anis¹,

Siddique²,

Naz³

et al. 2012

New Perspectives in Plant Protection

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“…The volumes of rat paw edema were determined using plethysmometer at 1, 2, and 3 h after edema induction. The percentage of edema inhibition was calculated (Palanichamy and Nagarajan, 1990). Two hours after edema induction, the extract showed dose-dependent inhibition and the extract at the dose of 600 mg/kg exhibited significantly anti-inflammatory activity (41% inhibition).…”

Section: Anti-inflammatory Activity Of a Trifoliatusmentioning

confidence: 99%