Analgesic activity of di-caffeoylquinic acids from roots of Lychnophora ericoides (Arnica da serra)

Santos, Michel David dos; Gobbo‐Neto, Leonardo; Albarella, Laura; Souza, Glória Emília Petto de; Lopes, Norberto Peporine

doi:10.1016/j.jep.2004.09.043

Cited by 83 publications

(80 citation statements)

References 20 publications

(20 reference statements)

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“…Ingredients 1, 2, 3, 4, 7, 8 and 9 were identified to be 5-dicaffeoylquinic acid, chlorogenic acid, 4-caffeoylquinic acid, caffeic acid, isochlorogenic acid B, isochlorogenic acid A, and isochlorogenic acid C. Caffeoylquinic acid derivatives are natural functional ingredients isolated from many herbal medicines and possess a broad range of pharmacological properties, including antioxidant, antibacterial, antihistaminic, anticancer, and other biological effects (Nakajima et al, 2007;Kwon et al, 2003). Recently, it has been demonstrated that isochlorogenic acid A and isochlorogenic acid C showed significant analgesic activity in the acetic acid-induced mouse writhing test (Dos Santos et al, 2005). Moreover, chlorogenic acid, isochlorogenic acid B and isochlorogenic acid A possessed potent anti-respiratory syncytial virus (RSV) activity against RSV (Li et al, 2005).…”

Section: Applicationmentioning

confidence: 99%

Simultaneous determination of organic acids and iridoid glycosides in traditional Chinese medicine (TCM) preparation reduning injection by rapid resolution liquid chromatography (RRLC) with ultraviolet (UV) detection under segmental monitoring mode

Chang¹

2013

Afr. J. Pharm. Pharmacol.

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A sensitive method of the simultaneous determination of organic acids and iridoid glycoside in reduning injection was described by rapid resolution liquid chromatography (RRLC) with ultraviolet (UV) detection under segmental monitoring mode. RRLC separation was achieved by use of a C 18 analytical column packed with sorbent of particle size 1.8 μm while the injected sample volume was set to 2 µl. A binary gradient elution program of aqueous phosphoric acid (0.1%, v/v) versus acetonitrile was selected for the quantitative analysis of nine major components. The RRLC-UV method under segmental monitoring mode showed satisfactory linearity, the limit of detection and the limit of quantitation. The method had been successfully applied to the determination of nine major components content in reduning injection samples. The analytical time of the proposed protocol is less than that of conventional HPLC-UV analytical methods, thus RRLC-UV method under segmental monitoring mode could function as an attractive alternative method to be used to evaluate the quality of reduning injection in the process of production.

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Section: Applicationmentioning

confidence: 99%

Simultaneous determination of organic acids and iridoid glycosides in traditional Chinese medicine (TCM) preparation reduning injection by rapid resolution liquid chromatography (RRLC) with ultraviolet (UV) detection under segmental monitoring mode

Chang¹

2013

Afr. J. Pharm. Pharmacol.

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“…The 2 species are very close, and the taxonomic separation between them is very complicated (Semir et al, 2011). The species are used in popular medicine as alcoholic extracts, such as anti-inflammatory, anesthetic, and scarring agents (dos Santos et al, 2005;Silveira et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Short Communication New loci of Lychnophora ericoides and transferability to Lychnophora pinaster, endangered medicinal species from Brazil

Vieira¹,

Marques²,

Haber³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Lychnophora ericoides and Lychnophora pinaster are species used in popular medicine as analgesic or anti-inflammatory agents to treat contusions, rheumatism, and insect bites. In this study, 21 simple sequence repeat loci of L. ericoides were developed and transferred to L. pinaster. Three populations of L. ericoides and 2 populations of L. pinaster were evaluated; they were collected in the State of Minas Gerais. Population parameters were estimated, and the mean values of observed and expected heterozygosity were 0.297 and 0.408 (L. ericoides) and 0.228 and 0.310 (L. pinaster), respectively. Greater genetic variability was observed within populations than between populations of L. ericoides (62 and 37%) and L. pinaster (97 and 2.8%). These results provide information for genetic conservation and taxonomic studies of these endangered species.

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“…Em outras espécies de Lychnophora, como L. salicifolia, detectou-se ação anti-inflamatória (Miguel et al 1996) e em extratos de L. rupestris, L. staavioides e L. diamantinana foi relatada atividade analgésica e anticonvulsivante (Taleb-Contini et al 2008). Além disso, descobriu-se que as raízes e as folhas produzem substâncias anti-inflamatória, enquanto os analgésicos estão apenas na raiz e o caule não produz substâncias de interesse farmacológico (Lopes 2001;Santos et al 2005). Outras substâncias presentes em L. ericoides, como o goiasensolido e a centraterina, são inibidores do mensageiro celular responsável pelo início da inflamação, evitando a formação das proteínas que desencadeiam o processo inflamatório (Lopes 2001).…”

Section: Introductionunclassified

Análise da variabilidade genética de arnica (Lychnophora ericoides Less. - Asteraceae) usando marcadores RAPDs

2009

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Recebido em 5/12/2007. Aceito em 15/07/2008 RESUMO -(Análise da variabilidade genética de arnica (Lychnophora ericoides Less.-Asteraceae) usando marcadores RAPDs). O objetivo deste trabalho foi analisar e quantificar a variabilidade genética entre e dentro das populações de arnica por meio de marcadores RAPD. Foram amostradas quatro populações na região geoeconômica do Distrito Federal: Parque Nacional de Brasília (2), Fazenda Água Limpa -UnB (1) e Reserva do Instituto Brasileiro de Geografia e Estatística (IBGE) (1). Folhas de 24 indivíduos de cada região foram coletadas, totalizando 96 indivíduos. Num total de 105 iniciadores testados foram selecionados 15, totalizando 60 bandas polimórficas. Marcadores RAPDs selecionados foram analisados com a utilização dos programas NTSYS e Amova. O dendrograma obtido pelo método UPGMA e coeficiente de dissimilaridade Dice evidenciou quatro agrupamentos consistentes, com índice de dissimilaridade variando entre 62 a 71%. O teste de Mantel aplicado estabeleceu uma correlação cofenética com valores de r = 0.82, significando que as distâncias geográficas entre as populações amostradas estão correlacionadas com a distância genética. A análise de AMOVA mostrou uma percentagem variabilidade genética entre populações de 35,7% e dentro de populações de 64,3%, evidenciando uma alta variação entre populações, sendo um importante resultado para definição de uma estratégia de conservação da espécie que se encontra em situação vulnerável à extinção. Palavras-chave: cerrado, marcadores moleculares, plantas medicinaisABSTRACT -(Genetic variability analysis of arnica (Lychnophora ericoides Less. -Asteraceae) using RAPD markers). The main objective of this research was to analyze and quantify the genetic variability within and between populations of arnica using RAPD markers. Four populations from Federal District area, Brazil were sampled: Parque Nacional de Brasília -(2 ), Fazenda Água LimpaUnB (1), and Reserva do Instituto Brasileiro de Geografia e Estatística (IBGE) (1). Leaves from twenty-four individuals from each population were collected and preserved under refrigeration. Fifteen primers were selected from 105 tested, totalizing 60 polymorphic bands. Scored RAPD markers were analyzed using NTSYS and Amova. The results indicated four consistent clusters, with dissimilarity index varying from 62 to 71%. The Mantel test indicates a cophenetic correlation (r-0.82), which means that the geographic distances are correlated to the genetic distances. An AMOVA analysis presented 35.7% variation among populations, and 64.3% within populations, showing a high variation among populations. This is an important result for conservation strategy for such species considered vulnerable to extinction.

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Analgesic activity of di-caffeoylquinic acids from roots of Lychnophora ericoides (Arnica da serra)

Cited by 83 publications

References 20 publications

Simultaneous determination of organic acids and iridoid glycosides in traditional Chinese medicine (TCM) preparation reduning injection by rapid resolution liquid chromatography (RRLC) with ultraviolet (UV) detection under segmental monitoring mode

Simultaneous determination of organic acids and iridoid glycosides in traditional Chinese medicine (TCM) preparation reduning injection by rapid resolution liquid chromatography (RRLC) with ultraviolet (UV) detection under segmental monitoring mode

Short Communication New loci of Lychnophora ericoides and transferability to Lychnophora pinaster, endangered medicinal species from Brazil

Análise da variabilidade genética de arnica (Lychnophora ericoides Less. - Asteraceae) usando marcadores RAPDs

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