Analgesic activity of medicinally important leaf of Diplazium esculentum

Abstract

The use of medicinal plants in modern medicine suffers from the fact that though hundred of plants are used in the world to prevent or to cure disease, scientific evidence in term of modern medicine is lacking in most cases. However, today it is necessary to provide scientific proof as to whether or not it is justified to use a plant or its active constituents. Pain and inflammation are considered one of the oldest known diseases of mankind and affects a large population of the world, unsatisfactory progress and lack of proper scientific evidences has enriched this disease worldwide. Diplazium esculentum is one of the most popular fern which is also used for medicinal purposes. Various parts of the D. esculentum are used for numerous purposes. However, its analgesic activity is still a mystery for the scientific world. So this study includes successive extraction and pharmacological evaluation of the analgesic activity of various extracts obtained from D. esculentum. To investigate the analgesic activity, 'acetic acid induced writhing' method in mice was used. The various extracts obtained were subjected to analgesic activity. The finding of this study highlighted several novels and important aspects of the extracts derived from D. Esculentum.

PRELIMINARY PHYTOCHEMICAL ANALYSIS AND LARVICIDAL ACTIVITY OF EDIBLE FERN (Diplazium esculentum (Retz.) Sw.) EXTRACT AGAINST Culex

“…Several studies have reported the activities of D. esculentum (Retz.) Sw. extract such as antibacterial [30,31], antioxidant [10,32,33,34], analgesic [20], hepatoprotective [35], anti-inflammatory [35], and anthelmintic [13]. Traditionally, some of its uses as a medicinal plant were as insecticides and repellent of insects and pests [10,13,20] 2).…”

“…Sw. extract such as antibacterial [30,31], antioxidant [10,32,33,34], analgesic [20], hepatoprotective [35], anti-inflammatory [35], and anthelmintic [13]. Traditionally, some of its uses as a medicinal plant were as insecticides and repellent of insects and pests [10,13,20] 2). The results showed a strong activity with LC50 value of 149.279 ppm.…”

“…Three large molecule families are generally considered: phenolics, terpenoids and steroids, and alkaloids [17]. Several studies have reported the secondary metabolite contents in D. esculentum [10,18,19,20,21], but fern plants from Indonesia have not been widely reported, even the secondary metabolite contents of Aceh fern has not been reported. Besides, larvicidal activity of D. esculentum also has not been reported.…”