Analgesic and anti-inflammatory activity and pharmacokinetics of alkaloids from seeds of Strychnos nux-vomica after transdermal administration: Effect of changes in alkaloid composition

Chen, Jun; Wang, Xuan; Qu, Yan-ge; Chen, Zhipeng; Cai, Hao; Xiao, Liu; Xu, Fei; Lu, Tulin; Cai, Baochang

doi:10.1016/j.jep.2011.10.038

Cited by 60 publications

(31 citation statements)

References 12 publications

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“…Brucine itself is known as an anti-inflammatory and analgesic drug for relieving arthritic and traumatic pain. [2][3][4] Its main pharmacodynamic actions include relief of pain, reduction of swelling and promotion of circulation. 5 Strychinin and brucine are the two main active ingredients of the semen strychni.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of novel NGR-modified liposomes containing brucine

Li¹

2017

IJN

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In this study, a novel NGR (Asn-Gly-Arg) peptide-modified liposomal brucine was prepared by using spray-drying method. The surface morphology of the liposomes, encapsulation efficiency and particle size were investigated. The data showed that the addition of NGR did not produce any significant influence on brucine liposomes in terms of particle size or zeta potential. In addition, after 3 months of storage, no dramatic change such as visible aggregation, drug content changes or precipitation in the appearance of NGR-brucine liposomes occurred. The in vitro release results indicated that the release of brucine from NGR liposomes was similar to that of liposomes, demonstrating that the NGR modification did not affect brucine release. The in vitro drug-release kinetic model of NGR-brucine liposomes fitted well with the Weibull’s equation. In vivo, NGR-brucine liposomes could significantly extend the bioavailability of brucine; however, there was no significant difference observed in the pharmacokinetic parameters between liposomes and NGR liposomes after intravenous administration. Antitumor activity results showed that NGR-modified liposomes exhibited less toxicity and much higher efficacy in HepG2-bearing mice compared with non-modified liposomes. The enhanced antitumor activity might have occurred because brucine was specifically recognized by NGR receptor on the surface of tumor cells, which enhanced the intracellular uptake of drugs.

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Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evaluation of novel NGR-modified liposomes containing brucine

Li¹

2017

IJN

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“…Acetic acid induced writhing: The peripheral analgesic activity of the samples was evaluated in mice using acetic acid induced writhing method (Amabeoku and Kabatende, 2012;Chen et al, 2012;Liao et al, 2012). Mice were divided into 4 groups of 4 mice in each group.…”

Section: Methodsmentioning

confidence: 99%

Analgesic and anti-diarrheal activities of Aganosma dichotoma (Roth) K. Schum. in Swiss-albino mice model

et al. 2015

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Aganosma dichotoma (Roth) K. Schum. is an indigenous plant of Bangladesh. Traditional healers use this plant to treat many diseases. In order to systematically explore the medicinal values of this plant, the crude methanol extract of leaves of A. dichotoma were screened for analgesic and antidiarrheal activities in mice model. The peripheral and central analgesic actions were determined by using acetic acid-induced writhing and tail immersion methods. The extract significantly (p < 0.05) attenuated the acetic acid-induced writhing in a dose dependent manner. A noticeable dose-dependent increase (p < 0.05) of latency period was also observed in the tail immersion method. In the castor oil induced anti-diarrheal assay, the extract exhibited significant (p < 0.05) anti-diarrheal effect at a dose of 400 mg/kg body weight.

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“…The peripheral analgesic activity of the samples was assesed in mice using acetic acid-induced writhing method (Amabeoku and Kabatende, 2012;Chen et al, 2012;Faruk et al, 2015). Mice were divided into 4 groups of 4 mice each.…”

Section: Acetic Acid-induced Writhingmentioning

confidence: 99%

In vitro Membrane Stabilizing and In vivo Analgesic Activities of Boehmeria glomerulifera Miq. in Swiss-Albino Mice Model

et al. 2016

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Boehmeria glomerulifera Miq. is an indigenous plant of Bangladesh. Traditional healers use this plant to treat various diseases. The crude methanol extract of whole plant of B. glomerulifera and its Kupchan fractions were screened for in vitro membrane stabilizing and only the crude extract at doses of 200-and 400-mg/kg body weight were screened for analgesic activity in mice model in order to establish the medicinal values of this plant. The membrane stabilizing activity of the extractives was evaluated by the ability of test materials to inhibit hypotonic solution-and heat-induced haemolysis of human erythrocytes. Moreover, the analgesic activity of methanol extract was evaluated by acetic acid induced writhing method and tail immersion method in mice. In hypotonic solution-and heat-induced conditions, the crude methanol extract showed inhibition of haemolysis by 64.80±0.34% and 21.63±0.76%, respectively as compared to 77.74±0.67% and 40.41±0.69% demonstrated by the standard, acetyl salicylic acid. On the other hand, the analgesic activity was determined for its peripheral and central pharmacological responses using acetic acid-induced writhing test and tail immersion method at doses of 200-and 400-mg/kg body weight. The extract reduced the acetic acid-induced writhings significantly (p < 0.05) in a dose dependent manner with the highest activity observed at 400 mg/kg (46.0%) body weight when compared to that of Diclofenac sodium (64.0%), as the standard drug. A significant increase (p < 0.01) of latency period was also found in tail immersion method. Therefore, the present study established that the methanol extract of B. glomerulifera possesses moderate membrane stabilizing and significant analgesic activities.

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Analgesic and anti-inflammatory activity and pharmacokinetics of alkaloids from seeds of Strychnos nux-vomica after transdermal administration: Effect of changes in alkaloid composition

Cited by 60 publications

References 12 publications

In vitro and in vivo evaluation of novel NGR-modified liposomes containing brucine

In vitro and in vivo evaluation of novel NGR-modified liposomes containing brucine

Analgesic and anti-diarrheal activities of Aganosma dichotoma (Roth) K. Schum. in Swiss-albino mice model

In vitro Membrane Stabilizing and In vivo Analgesic Activities of Boehmeria glomerulifera Miq. in Swiss-Albino Mice Model

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