Analgesic and anti-inflammatory activity of crude leaf and bark extract of Lantana Camara

Abstract

The purpose of present study was to investigate the analgesic and anti-inflammatory activity of Lantana camara (Verbenaceae) leaf and bark extract. The methanol extract of Lantana camara (MELC) was screened for possible analgesic activity by acetic acid, hot plate and anti-inflammatory activity by carrageenan and histamine induced paw edema. The result showed that, MELC (100 mg/kg and 200 mg/kg) leaf and bark possessed significant (P <0.01 and P <0.05) anti-inflammatory response and 200 mg/kg dose of MELC leaf and bark showed more significant (P <0.01) analgesic activity as compared to the 100 mg/kg dose. Preliminary phytochemical screening result shows the presence of several phytochemicals which may responsible for its anti-inflammatory and analgesic actions. The results indicate the MELC showed great potential for analgesic and anti-inflammatory activity and may be useful for the medical purpose.

Composition, Seasonal Variation, and Biological Activities of Lantana camara Essential Oils from Côte d’Ivoire

“…However, it is also possible that some other compounds interact synergistically or antagonistically. The anti-inflammatory activity of L. camara extracts has previously been demonstrated in several studies [12,[74][75][76]. However, IC 50 values were lower than 17.75 µg/mL in the present study (IC 50 of L. camara essential oil from Peru was 81.5 µg/mL [7]), indicating that L. camara is a plant with anti-inflammatory properties in various forms, supporting the wide use of this plant in traditional medicine for its anti-rheumatism properties [5].…”

“…Different solvent extracts produced from L. camara have already been studied, showing the occurrence of flavonoids, triterpenes, and glycosides [5]. These extracts and compounds were described as having interesting antioxidant, anti-inflammatory [11][12][13], antibacterial, cytotoxic, antifungal, anthelmintic [14][15][16][17][18], and insecticidal properties [19,20]. Some studies have also focused on L. camara essential oils, showing the high diversity in essential oil compositions depending on plant growth area.…”

Antioxidant and anti-inflammatory potentials of Solanum pubescens Willd an ethnomedicinal plant of South Western Andhra Pradesh, India

“…It is well established that medicinal plants are consistently explored for their therapeutic potentials from ages. Preclinical and clinical studies on various medicinal plants and their phytoconstituents have reported for exhibiting potential anti-inflammatory activities in the management of complex conditions like psoriasis and cancer [5][6][7][8][9].…”

Chemical Constituents and Pharmacological Activities of Lantana Camara – A Review

“…Methanolic extracts of the leaves and bark of lantana extract at a dose of 2000 mg/kg orally, do not exhibit any signs of toxicity in rats up to 14 days and no animal died [85].…”

“…Methanolic extracts of the leaves and bark of lantana extract were screened for analgesic activity by acetic acid and hot plate, and antiinflammatory activity by carrageenan and histamine-induced paw edema models. Methanolic leaf and bark extracts (100 and 200 mg kg body weight BW) possessed significant anti-inflammatory effects, and at 200 mg/kg dose, the extracts showed significant analgesic activity [85].…”