Analgesic and Anti-Inflammatory Effects of Aqueous Extract of <i>Zea mays</i> Husk in Male Wistar Rats

Owoyele, Bamidele Victor; Negedu, Muhammed Nafiu; Olaniran, Samuel Oluyinka; Onasanwo, Samuel Adetunji; Atolanı, Olubunmi; Sanya, Joseph Olurotimi; Oyeleke, Sabitiu A.; Ibidapo, Adekemi J.; Soladoye, Ayodele O.

doi:10.1089/jmf.2008.0311

Cited by 35 publications

(17 citation statements)

References 14 publications

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“…; i.p. for 21 days); 10 Group III (BTE dose of 2.5 g tea leaf/dl of water that is 2.5% of aqueous BTE also for 21 days orally) and Group IV (both indomethacin and BTE simultaneously for 21 days). All the animals were sacrificed at the end of the last dose after an overnight fast.…”

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confidence: 99%

Black tea extract ameliorates indomethacin induced changes in testicular histopathology of albino rats

Bagoji¹,

Doshi²,

Yendigeri³

et al. 2014

J. Young Pharm.

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Context:Reactive oxygen species and lipid peroxidation play a role in the pathogenesis induced by the non-steroidal antiinflammatory drug indomethacin. Aims: This study was aimed to assess the simultaneous effect of black tea extract (BTE) on indomethacin induced alteration in testicular pathology. Materials and Methods: Adult rats were divided into four groups (n = 6/group); Group I (control); Group II (indomethacin, 5 mg/kg b.wt.; i.p.); Group III (BTE, 2.5 g tea leaf/dL of water, i.e., 2.5% of aqueous BTE, orally) and Group IV (indomethacin + BTE). Serum vitamin E, sperm count, motility, and histopathology of testes were evaluated. Statistical Analysis: Statistical comparisons were performed using the one-way ANOVA, followed by post-hoc t-test. Results: Indomethacin induced rats showed a significant decrease in testicular weight, sperm count, sperm motility, and serum vitamin E concentrations. Histopathology of the testes revealed tortuous seminiferous tubules, loss of spermatogenesis process, marked decrease in the number of interstitial cells of Leydig and been replaced by many foci of congestion, edema, necrosis, and interstitial fibrosis. Rats simultaneously treated with BTE and indomethacin showed improvement of testicular weight, sperm count, sperm motility, and serum vitamin E concentrations when compared to indomethacin alone treated rats. Similarly, histopathology of rats treated simultaneously with indomethacin and BTE showed near normal testicular architecture when compared to indomethacin alone treated rats. Conclusion: The result suggests that BTEs might have potential beneficial effect to combat against indomethacin induced testicular damage in rats.

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confidence: 99%

Black tea extract ameliorates indomethacin induced changes in testicular histopathology of albino rats

Bagoji¹,

Doshi²,

Yendigeri³

et al. 2014

J. Young Pharm.

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“…Consumption of Zea mays husk and soy-containing diets suppressed pain in rats up to a significant level. [33,34] These results provide scientific validation for the use of Zea mays husk and Cucurbita maxima seeds for treating pain and inflammatory conditions in Nigerian folk medicine and Brazil, respectively. [34] DPP-III Inhibitory Peptides in Chicken and Bovine Proteins…”

Section: Dpp-iii Inhibitory Peptides In Plant Proteinsmentioning

confidence: 67%

In SilicoEvaluation of Potential DPP-III Inhibitor Precursors from Dietary Proteins

Khaket

Redhu

Dhanda

et al. 2014

International Journal of Food Properties

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Dipeptidyl peptidase-III is an important enkephalin degrading enzyme and its inhibitors are expected to be promising in pain management. Some of its inhibitors showed an antinociceptive potential. The present study investigated the evaluation of dietary proteins as potential precursors of dipeptidyl peptidase-III inhibitors by measuring occurrence frequency of dipeptidyl peptidase-III inhibitory peptides. In silico analysis of 69 proteins from 17 food commodities revealed 2659 dipeptidyl peptidase-III inhibitory peptides. β-subunit of hemoglobin and annexin A5 of chicken showed highest dipeptidyl peptidase-III inhibiting potential followed by 12S seed storage globulin 2 of oat, β-conglycinin of soyabean, α-lactalbumin of cow milk, cruciferin CRU4 of rapeseed, and zein-alpha of maize But overall occurrence frequency of dipeptidyl peptidase-III inhibitory peptides was observed highest in maize followed by pumpkin, soyabean, and rapeseed, whereas barley showed the lowest frequency among plant based foods. Chicken and maize had the highest dipeptidyl peptidase-III inhibitory potential in animal and plant derived foods respectively, thus may serve as a natural dietary source for pain modulation.

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“…Previously, tannins and saponins isolated from medicinal plants exhibited analgesic and anti-inflammatory activities (Thomas et al, 1985;Owoyele et al, 2010;Choi et al, 2005). We thus suggested that the tannins and saponins present in C. vogelii extract were responsible for its analgesic and anti-inflammatory activities.…”

Section: Discussionmentioning

confidence: 92%

Analgesic and anti-inflammatory effects of Cyphostemma vogelii (Hook. f.) Desc. root extract in mice

Udegbunam¹,

Udegbunam²,

Anosa³

2013

Afr. J. Biotechnol.

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Cyphostemma vogelii (family: Vitaceae) is a herbaceous plant which grows in Obukpa town in SouthEastern Nigeria. C. vogelii is said to be generally medicinal though no specific medicinal activity was mentioned in the literature for this plant. The analgesic effect of C. vogelii was evaluated using acetic acid-induced writhing and formalin-induced nociception tests. The extract was also screened for antiinflammatory activity using carrageenan-induced and kaolin-carrageenan-induced paw edema tests. C. vogelii extract dose dependently inhibited acetic acid-induced pain in mice. The extract at 200 and 400 mg/kg significantly inhibited inflammatory and neurogenic pain induced by formalin. The effects of 200 mg/kg on formalin induced pain were similar to those of aspirin, while 400 mg/kg produced more inhibitory effects. At 2, 3 and 5 h post carrageenan injection, 200 and 400 mg/kg extract significantly inhibited paw edema. The extract dose dependently suppressed kaolin-carrageenan-induced edema from 3 h post treatment for up to 24 h. The effect of 400 mg/kg on kaolin-carrageenan-induced edema was similar to that of aspirin, while 100 mg/kg showed the least activity. The data obtained from this study showed that the methanol extract of C. vogelii exhibited mild analgesic activity as well as antiinflammatory activity.

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Analgesic and Anti-Inflammatory Effects of Aqueous Extract of Zea mays Husk in Male Wistar Rats

Cited by 35 publications

References 14 publications

Black tea extract ameliorates indomethacin induced changes in testicular histopathology of albino rats

Black tea extract ameliorates indomethacin induced changes in testicular histopathology of albino rats

In SilicoEvaluation of Potential DPP-III Inhibitor Precursors from Dietary Proteins

Analgesic and anti-inflammatory effects of Cyphostemma vogelii (Hook. f.) Desc. root extract in mice

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