Analgesic and anti-inflammatory properties of essential oil from Ageratum fastigiatum

Del-Vechio-Vieira, Glauciemar; Sousa, Orlando Vieira de; Miranda, Mariza Abreu; Senna-Valle, Luci de; Kaplan, Maria Auxiliadora Coelho

doi:10.1590/s1516-89132009000500008

Cited by 29 publications

(17 citation statements)

References 19 publications

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“…In the current study the β-cedrene was not detected, the α-humulene appear in small amount (1.35%) and the germacrene D was not majority terpene (9.09%), being the α-pinene (51.27%) the main component observed. More abundant components in our research (trans-β-caryophyllene, β-pinene and β-ocimene) were not detected by Del-Vechio-Vieira et al (2009a). Among the factors that could influence those differences between the two researches we can mention the use of fresh material in our study and the use of dry leaves on the previous work.…”

Section: Resultsmentioning

confidence: 55%

“…The analysis of essential oils of this species revealed the sesquiterpenes prevalence; however, qualitative and quantitative differences are observed in their composition when derived from different tissues or individuals (Del-Vechio-Vieira et al, 2009a;DelVechio-Vieira et al, 2009b). Those variations in secondary metabolites are influenced by intrinsic factors (genetics, development, growth, vegetable organ) and extrinsic (atmospheric conditions, geographic region, soil type, presence of predators or pathogens, among other environmental factors) to plants Castro et al, 2004;Gobbo-Neto & Lopes, 2007).…”

Section: Introductionmentioning

confidence: 90%

“…Those variations in secondary metabolites are influenced by intrinsic factors (genetics, development, growth, vegetable organ) and extrinsic (atmospheric conditions, geographic region, soil type, presence of predators or pathogens, among other environmental factors) to plants Castro et al, 2004;Gobbo-Neto & Lopes, 2007). Studies on the biological potential of essential oils and polar extracts of A. fastigiatum revealed antimicrobial, analgesic and anti-inflammatory activities (Del-VechioVieira et al, 2007;Del-Vechio-Vieira et al, 2009a;Del-Vechio-Vieira et al, 2009b). In spite of other published works, variations in metabolism reported in these researches, and because it is a medicinal plant, stimulate the restudy of the chemical composition of A. fastigiatum, collected in Diamantina region.…”

Section: Introductionmentioning

confidence: 99%

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Contribution for the phytochemical studies of Ageratum fastigiatum

Gonçalves¹,

Almeida²,

Oliveira³

et al. 2011

Rev. bras. farmacogn.

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Organic extracts from leaves plus branches plus inflorescences of Ageratum fastigiatum (Gardner) R. M. King & H. Rob., Asteraceae, were fractionated through classic chromatography. The steroids stigmasterol, chondrillasterol and campesterol were isolated from hexane extract. The triterpenes lupeol, taraxasterol, α-amyrin, β-amyrin, pseudotaraxasterol, lupeol acetate and α-amyrin acetate were isolated from ethyl acetate extract. Steroids and triterpenes were identified by GC-MS. The coumarin ayapin was isolated from ethanol extract and identified by NMR. Essential oils of the fresh leaves and fresh inflorescences were obtained by hydrodistillation and analyzed for GC-MS. The main components in both essential oils were α-pinene, limonene and germacrene D.

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Section: Resultsmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Contribution for the phytochemical studies of Ageratum fastigiatum

Gonçalves¹,

Almeida²,

Oliveira³

et al. 2011

Rev. bras. farmacogn.

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“…These receptors are recognized as important targets for modulation by sedative, anxiolytic and general anesthetic agents (Franks & Lieb, 1994). Del-Vechio-Vieira et al (2009) described the analgesic activity of EO from leaves of Ageratum fastigiatum in mice, whose main component was germacrene D. Studies regarding this activity related to bicyclogermacrene were not found in literature. To the best of our knowledge this is the first study that describes the anesthetic activity of this EO.…”

Section: Transportation Experimentmentioning

confidence: 99%

Anesthesia and transport of fat snook Centropomus parallelus with the essential oil of Nectandra megapotamica(Spreng.) Mez

et al. 2013

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This study analyzed the chemical composition and anesthetic potential of essential oil (EO) of Nectandra megapotamica in fat snook (Centropomus parallelus). For the extraction of EO by hydrodistillation, leaves were separated in young (EO-Y) or old (EO-O), and the chemical composition of the EOs was determined by CG-MS. The anesthetic potential was assessed by the evaluation of induction and recovery time of anesthesia and stress response from anesthesia and transport. Three experiments were carried out: i) four different concentrations of each EO were tested to evaluate anesthesia induction and recovery time; ii) two concentrations of EO-O were tested for the evaluation of its effects on stress parameters (glucose, lactate, and Na + and K + plasma levels) caused by anesthesia; and iii) fish were transported in plastic bags, supplied with two concentrations of EO-O for the evaluation of water quality and mortality. All experiments were performed on fish acclimated to 0 and 33 ppt salinity. The main constituents of the Y and O-EOs were bicyclogermacrene (46.5/34.6%), α-pinene (26.8/26.2%), β-pinene (7.9/12.3%), and germacrene D (9.6/9.1%). Mild sedation was achieved at 30 µL L -1 (1.3-3.2 min) and deep anesthesia at 150 µL L -1 (5.6-8.0 min) with both EOs. The recovery time ranged from 1-10 min. The EO-O was not able to avoid the stress of anesthesia evidenced by elevated glucose and lactate plasma levels observed in all groups. Plasma levels of Na + and K + were not significantly affected by treatments. During transport, the use of EO-O did not prevent deterioration in water quality and the post-transport mortality. In conclusion, the EO of N. megapotamica has anesthetic activity in fat snook, but it was not able to prevent the stress of anesthesia and transport.Este estudo analisou a composição química e o potencial anestésico do óleo essencial (OE) de Nectandra megapotamica em robalos-peva (Centropomus parallelus). Para a extração do OE por hidrodestilação, as folhas foram separadas em jovens (OE-J) ou velhas (OE-V) e a composição química foi determinada por CG-EM. O potencial anestésico foi acessado através da avaliação do tempo de indução e recuperação da anestesia e resposta ao estresse do procedimento anestésico e transporte. Foram realizados três experimentos: em primeiro lugar, quatro concentrações diferentes de cada OE foram testadas para avaliar o tempo de indução à anestesia e de recuperação; em segundo lugar, duas concentrações do OE-V foram testadas para avaliar os efeitos sobre os parâmetros de estresse (níveis plasmáticos de glicose, lactato, Na + e K + ) causados pelo procedimento anestésico; em terceiro lugar, os peixes foram transportados em sacos plásticos com duas concentrações do OE-V para avaliação da qualidade da água e mortalidade. Todos os experimentos foram realizados em peixes aclimatados à salinidade zero e 33. Os constituintes majoritários do OE-J e OE-V foram: biciclogermacreno (46,5/34,6%), α-pineno (26,8/26,2%), β-pineno (7,9/12,3%) e germacreno D (9,6/9,1%). Sedação leve foi alca...

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“…[27][28][29] Consequently, there is a strong interest in searching for new anti-inflammatory agents from natural products. [30][31][32] Studies on the anti-inflammatory activity of solvent extracts of seaweeds and seagrass have been conducted previously. 16,20,33,34 However, very few studies have investigated the anti-inflammatory activity of sulfated polysaccharides obtained from seaweeds.…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and Anti-Inflammatory Activities of Sargassum wightii and Halophila ovalis Sulfated Polysaccharides in Experimental Animal Models

Yuvaraj

Kanmani²,

Satishkumar

et al. 2013

Journal of Medicinal Food

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The present study investigated the effects of sulfated polysaccharides from brown seaweed Sargassum wightii (Sw-SP) and seagrass Halophila ovalis (Ho-SP) in nociceptive and inflammatory models. In the formalin test, Sw-SP and Ho-SP significantly reduced licking time in both phases of the test at a dose of 10 mg/kg. In the hot plate test, the antinociceptive effect was observed only in animals treated with 10 mg/kg of Sw-SP and 5, 10 mg/kg of Ho-SP, suggesting that the analgesic effect occurs through a central action mechanism at the higher dose. Sw-SP and Ho-SP (10 mg/kg) significantly inhibited paw edema induced by carrageenan, especially at 3 h after treatment and potentially decreased neutrophil migration by 53% and 52%, respectively. In Freund's adjuvant-induced arthritic rats, there was a significant increase in the rat paw volume and decrease in body weight, but in Sw-SP- and Ho-SP-treated groups (10 mg/kg), a significant reduction in paw volume and a normal gain in body weight were observed. The present results indicate that Sw-SP and Ho-SP possess antinociceptive and anti-inflammatory effects and have potential usefulness for development as therapeutic agents.

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Analgesic and anti-inflammatory properties of essential oil from Ageratum fastigiatum

Cited by 29 publications

References 19 publications

Contribution for the phytochemical studies of Ageratum fastigiatum

Contribution for the phytochemical studies of Ageratum fastigiatum

Anesthesia and transport of fat snook Centropomus parallelus with the essential oil of Nectandra megapotamica(Spreng.) Mez

Antinociceptive and Anti-Inflammatory Activities of Sargassum wightii and Halophila ovalis Sulfated Polysaccharides in Experimental Animal Models

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