Analgesic and antipyretic activities of Momordica charantia linn. fruits

Patel, Rohit B.; Mahobia, Naveen K.; Upwar, Nitin; Waseem, Naheed; Talaviya, Hetal; Patel, Zalak

doi:10.4103/0110-5558.76441

Cited by 33 publications

(17 citation statements)

References 12 publications

(9 reference statements)

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“…It is tasteless, crystalline in nature, whitish in color and melts at 266–268 °C. Chemically it is a typical cucurbitane-type triterpenoid [130–131] . Charantin is reported for antidiabetic activity [132–133] and anti-bacterial activity [134] .…”

Section: Introductionmentioning

confidence: 99%

Bitter melon: a panacea for inflammation and cancer

Dandawate

Subramaniam

Padhyé³

et al. 2016

Chinese Journal of Natural Medicines

115

123

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Nature is a rich source of medicinal plants and their products that are useful for treatment of various diseases and disorders. Momordica charantia, commonly known as bitter melon or bitter gourd, is one of such plants known for its biological activities used in traditional system of medicines. This plant is cultivated in all over the world, including tropical areas of Asia, Amazon, east Africa, and the Caribbean and used as a vegetable as well as folk medicine. All parts of the plant, including the fruit, are commonly consumed and cooked with different vegetables, stir-fried, stuffed or used in small quantities in soups or beans to give a slightly bitter flavor and taste. The plant is reported to possess anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-bacterial, anti-obesity, and immunomodulatory activities. The plant extract inhibits cancer cell growth by inducing apoptosis, cell cycle arrest, autophagy and inhibiting cancer stem cells. The plant is rich in bioactive chemical constituents like cucurbitane type triterpenoids, triterpene glycosides, phenolic acids, flavonoids, essential oils, saponins, fatty acids, and proteins. Some of the isolated compounds (Kuguacin J, Karaviloside XI, Kuguaglycoside C, Momordicoside Q–U, Charantin, α-eleostearic acid) and proteins (α-Momorcharin, RNase MC2, MAP30) possess potent biological activity. In the present review, we are summarizing the anti-oxidant, anti-inflammatory, and anti-cancer activities of Momordica charantia along with a short account of important chemical constituents, providing a basis for establishing detail biological activities of the plant and developing novel drug molecules based on the active chemical constituents.

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Section: Introductionmentioning

confidence: 99%

Bitter melon: a panacea for inflammation and cancer

Dandawate

Subramaniam

Padhyé³

et al. 2016

Chinese Journal of Natural Medicines

115

123

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“…[81617] There also are flavonoids, quercetin, and luteolin. [1819] Saponins include momordicin, momordin, momordicoside, karavilagenin, karaviloside, and kuguacin.…”

Section: Phytochemical Substancesmentioning

confidence: 99%

An update review on the anthelmintic activity of bitter gourd, Momordica charantia

Poolperm¹,

Jiraungkoorskul²

2017

Phcog Rev

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Momordica charantia (Family: Cucurbitales), as known as bitter melon or gourd, is a daily consumption as food and traditional medicinal plant in Southeast Asia and Indo-China. It has been shown to possess anticancer, antidepressant, antidiabetic, anti-inflammatory, antimicrobial, antiobesity, antioxidant, and antiulcer properties. Its common phytochemical components include alkaloids, charantin, flavonoids, glycosides, phenolics, tannins, and terpenoids. This plant is rich in various saponins including momordicin, momordin, momordicoside, karavilagenin, karaviloside, and kuguacin, all of which have been reported to contribute to its remedial properties including antibacterial, antifungal, antiviral, and antiparasitic infections. Based on established literature on the anthelmintic activity of M. charantia and possible mode of action, this review article has attempted to compile M. charantia could be further explored for the development of potential anthelmintic drug.

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“…The ethanolic extracts (500 mg kgG 1 ) of M. charantia fruit showed antipyretic effect in a study which was carried out using yeast-induced pyrexia in rats. The antipyretic activity of M. charantia may be due to the individual or combined action of bioactive constituents present in it (Patel et al, 2010).…”

Section: Antipyretic Effectmentioning

confidence: 99%