Analgesic, anti-inflammatory and antipyretic activities of the methanol leaf extract of Dalbergia saxatilis Hook.F in rats and mice

Hassan, Farooq; Zezi, Abdulkadir Umar; Yaro, Alpha Seydou; Danmalam, U.H.

doi:10.1016/j.jep.2015.03.007

Cited by 28 publications

(18 citation statements)

References 7 publications

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“…D. moldavica extracts also possess sedative and analgesic activities [ 33 ]. It is reported that the abdominal constriction is related to the sensitization of nociceptive receptors to prostaglandins [ 34 , 35 ]. Local irritation produced by an intraperitoneal injection of acetic acid triggers the release pro-inflammatory cytokines such as IL-1, IL-6, IL-8 and TNF-α [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

In in vivo evaluation of the anti-inflammatory and analgesic activities of compound Muniziqi granule in experimental animal models

Cheng

Liu

et al. 2015

BMC Complement Altern Med

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Background: Compound Muniziqi granule (MNZQ), a traditional Uighur medicinal preparation, comprises 13 species of medicinal plants. MNZQ is traditionally used for regulating body immunity, modulating inflammation and pain, detoxification, and inhibiting tumor growth. This study aims to scientifically evaluate the anti-inflammatory and analgesic activities of MNZQ, support its clinical use and further research with scientific evidence. Methods: The analgesic activity of MNZQ was evaluated using hot plate test and acetic acid-induced abdominal writhing test. Acute inflammation was evaluated using xylene-induced ear edema and carrageenan-induced paw edema models, while chronic inflammation was evaluated using cotton pellet-induced granuloma model. Results: MNZQ exerted analgesic activities with a significant dose-dependent increase in latency in the hot plate test. The percentage inhibition suggested that MNZQ exhibited analgesic activities in the central nervous system. Meanwhile, MNZQ at 0.8, 2.4, and 7.2 g/kg strongly inhibited the acetic acid-induced writhing response by 25.22 % (p < 0.01), 44.60 % (p < 0.001), and 49.41 % (p < 0.001), respectively. MNZQ also exerted analgesic activities in the peripheral nervous system. Moreover, MNZQ was demonstrated a significant anti-inflammatory effect against xylene-induced edema in a dose-dependent manner. The percentage inhibition was 22.24 % (p < 0.01) at the highest dosage of 7.2 g/kg. MNZQ at 1.62 and 4.86 g/kg significantly reduced carrageenan-induced rat hind paw edema by 82.43 % and 84.32 % (p < 0.001), respectively, 1 h after injecting carrageenan, and the inhibitory effect lasted for 5 h. MNZQ also exerted a significant anti-inflammatory effect against cotton pellet-induced granuloma formation. MNZQ at 1.62 and 4.86 g/kg could inhibit granuloma formation by 17.07 % and 17.60 %, respectively, whereas the percentage inhibition of diclofenac was 33.12 %. Conclusions: The results obtained suggest that MNZQ possesses potential anti-inflammatory and analgesic activities. This study provides a scientific basis for the use of MNZQ in alleviating pain and treating inflammatory disorders.

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Section: Discussionmentioning

confidence: 99%

In in vivo evaluation of the anti-inflammatory and analgesic activities of compound Muniziqi granule in experimental animal models

Cheng

Liu

et al. 2015

BMC Complement Altern Med

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“…Pain according to the International Association for the Study of Pain (IASP) is unpleasant, sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. 1 …”

Section: Introductionmentioning

confidence: 99%

Studies on analgesic, anti-inflammatory activities of stem and roots of Inula cuspidata C.B Clarke

Paliwal

Sati

Faujdar

et al. 2017

Journal of Traditional and Complementary Medicine

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The present study was carried out to evaluate analgesic and anti-inflammatory activities in Inula cuspidata stem and root extracts along with heavy metals estimation in stem and root powder.Stem and roots were extracted with chloroform (ICSCE, ICRCE) and methanol (ICSME, ICRME). Acute oral toxicity of all extracts was determined by OECD guidelines 425. Analgesic activity was investigated by using hot plate and acetic acid induced writhing models. Anti-inflammatory activity (acute) of all extracts was evaluated by carrageenan induced paw edema model. In addition, root and stem powder was screened for heavy metals (As, Pb, Cd, Hg) estimation using atomic absorption spectroscopy. In acute toxicity study no mortality was observed when each extract was orally administered with 2.0 g/kg. At the doses (100 and 200 mg/kg) ICRME followed by ICSME showed significant and dose dependent analgesic and anti-inflammatory effects compared with chloroform extracts. The heavy metals concentration in stem and root powders was found to be within the permissible limits as recommended by WHO for herbal raw materials. The findings of the present study validated the folkloric use of Inula cuspidata as analgesic and anti-inflammatory. In addition, the results intimate that heavy metals present in raw material were found to be within the defined limits, and it exhibits that the therapeutic efficacy of plant may not be effected, which can be otherwise possibly effected if the plant sequester high concentration of heavy metals from the polluted environment as well as from the soil rich in pesticides and sewage sludge etc.

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“…The extractives of many Dalbergia species are known for their analgesic, anti-inflammatory and antipyretic activities and used in case of cough, toothache, skin lesions and stomach ache, etc. (Rasamiravaka et al 2013;Saha et al 2013;Chen et al 2015;Hassan et al 2015). Also the wood of a number of Dalbergia trees is highly estimated as high-quality and high-value timber, such as the rosewoods, which include the Brazilian rosewood (Dalbergia nigra), Indian rosewood (Dalbergia latifolia), Madagascar rosewood (Dalbergia maritima) and Huanghuali rosewood (Dalbergia odorifera).…”

Section: Introductionmentioning

confidence: 99%

The phylogenetic analysis of Dalbergia (Fabaceae: Papilionaceae) based on different DNA barcodes

Wang

et al. 2017

Holzforschung

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Abstract:The genus Dalbergia contains approximately 250 species with many valuable trees being destroyed by targeted and illegal logging. DNA barcoding is a reliable method for the molecular identification of different species and resources conservation. In the present study, the specimen discrimination ability of internal transcribed spacer (ITS), matK, rbcL and psbA-trnH barcoding were tested on Dalbergia sequences, downloaded from the National Center for Biotechnology Information (NCBI), and the combined barcoding ITS + matK + rbcL was used to identify unknown specimens. It was found that ITS + matK + rbcL have good discrimination rates based on the analysis methods best match (BM) and best close match (BCM). These barcodes also have the best performance concerning barcode gap distribution, and are able to discriminate unknown specimens from South-China. Furthermore, it was demonstrated that D. tamarindifolia and D. rubiginosa are also relatively close to sister-species D. pinnata and D. candenatensis within the phylogenetic Dalbergia tree. Considering the overall performance of these barcodes, we suggest that the ITS + matK + rbcL region is a suitable barcode for identifying Dalbergia species.

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Analgesic, anti-inflammatory and antipyretic activities of the methanol leaf extract of Dalbergia saxatilis Hook.F in rats and mice

Cited by 28 publications

References 7 publications

In in vivo evaluation of the anti-inflammatory and analgesic activities of compound Muniziqi granule in experimental animal models

In in vivo evaluation of the anti-inflammatory and analgesic activities of compound Muniziqi granule in experimental animal models

Studies on analgesic, anti-inflammatory activities of stem and roots of Inula cuspidata C.B Clarke

The phylogenetic analysis of Dalbergia (Fabaceae: Papilionaceae) based on different DNA barcodes

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