Analgesic bisbenzylisoquinoline alkaloids from the rhizoma of Menispermum dauricum DC

Wei, Hongli; Wang, Jixia; Hou, Tao; Yao, Yu-Min; Jin, Jingmei; Zhao, T F; Zhang, Xiuli; Liu, Yanfang; Liang, Xinmiao

doi:10.1016/j.bioorg.2020.104517

Cited by 14 publications

(2 citation statements)

References 32 publications

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“…N-oxides of dauricine-type BBIs and rare tail-to-tail quaternary alkaloids were identified from the rhizome of Menispermum dauricum. (56) N-methylcorydaldine, thalifoline, stepholidine, acutumine, daurisoline, acutumidine, dauricicoline, bianfugecine, 6-O-demethylmenisporphine, bianfugedine, dauricoside, eleutheroside D, aristolactone, aristoloterpenate Ⅰ and aristolochic acid were identifi ed from M. dauricum. (57) Tinospora Alkaloids (including protoberberine, aporphine BIAs), sesquiterpenoids, diterpenoids (mainly clerodane type), phenolics, steroids, aliphatic compounds and polysaccharides were found in Tinospora cordifolia.…”

Section: Cocculusmentioning

confidence: 99%

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants

Hao

Zheng

et al. 2022

Chin. J. Integr. Med.

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Ranunculales is an order of angiosperms, containing 7 families, i.e., Ranunculaceae (at least 50 genera, >2,000 species), Berberidaceae (17 genera, 650 species), Menispermaceae (65 genera, >350 species), Lardizabalaceae (9 genera, 50 species), Circaeasteraceae (2 species), Papaveraceae (38 genera, >700 species), and Eupteleaceae (2 species, Appendix 1). Ranunculales belongs to the basal eudicots, in which it is the most basal clade; its widely known members include poppies, barberries, monseed, akebia and buttercupss. The chemodiversity of Ranunculaceae, the fl agship family of Ranunculales, and their correlation with the biodiversity and pharmacotherapy, have been systematically reviewed by us in the context of pharmacophylogeny. (1) In recent years, the research enthusiasm for the other 4 major Ranunculales families has been growing rapidly, as plants of these families also meet human needs for food, fl avours, fragrances, and not the least, medicines during long history. Ranunculales plants form the basis of sophisticated traditional medicine systems, e.g., Chinese medicine (CM) and Ayurveda medical system. (2) These systems of medicine give rise to some important Ranunculalesbased drugs still in use today. (3,4) According to incomplete statistics, 573 Ranunculaceae and 308 Berberidaceae species were in medicinally hot nodes; (4) the therapeutic efficacy of 2 families differed substantially. For instance, up to 361 Chinese Ranunculaceae species are used against musculoskeletal diseases, followed by 321 against hepatic diseases, 242 against circulatory diseases, and 210 against skin diseases, etc.; in contrast, as many as 251 Chinese Berberidaceae species are used against eyesight diseases, followed by 249 against hepatic diseases, 242 against digestive diseases and 90 against oral diseases, etc. Nevertheless, except Ranunculaceae, the

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Section: Cocculusmentioning

confidence: 99%

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants

Hao

Zheng

et al. 2022

Chin. J. Integr. Med.

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“…is a plant of the Menispermaceae family, which is widely distributed in China. The rhizome of this plant is used in traditional Chinese medicine (TCM) and is known as Menispermi Rhizoma (“BeiDouGen” in Chinese) ( Wei et al, 2021 ). Menispermi Rhizoma has a wide range of pharmacological activities, such as anti-hypoxia ( Shao et al, 2019 ), anti-inflammatory ( Sun et al, 2014 ; Qiao et al, 2019 ), anti-Alzheimer’s disease ( Liu et al, 2018 ), anti-arrhythmia ( Liu and Han, 2000 ), and anti-MI effects ( Yu et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Integrated Serum Pharmacochemistry and Network Pharmacology Approach to Explore the Effective Components and Potential Mechanisms of Menispermi Rhizoma Against Myocardial Ischemia

Wei

Zhang

et al. 2022

Front. Chem.

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Background: Myocardial ischemia (MI) is a leading cause of death worldwide. Menispermi Rhizoma is a traditional Chinese medicine that exerts a variety of beneficial pharmacological activities in many diseases, including MI.Purpose: Serum pharmacochemistry and network pharmacology were used to explore the material basis and mechanism of action of Menispermi Rhizoma against MI.Methods: The absorbed components of Menispermi Rhizoma in rat plasma were analyzed by ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF/MS). The key components, targets, pathways, and interrelated information were obtained by network pharmacology. The potential effective components of Menispermi Rhizoma against MI were screened by methyl-thiazolyl-tetrazolium (MTT) assay, and the cardioprotective effect and mechanism of active components were verified by Western blotting and molecular docking.Results: In total, 25 absorbed components of Menispermi Rhizoma in plasma were identified. Network pharmacology revealed 81 major targets of Menispermi Rhizoma against MI, mainly involving the regulation of the PI3K/AKT and MAPK pathways. In vitro validation of H9c2 cells revealed that acutumine, daurisoline, dauricoside, and 6-O-demethylmenisporphine are the main bioactive components of Menispermi Rhizoma. The levels of lactate dehydrogenase, creatine kinase, and malondialdehyde (MDA) were significantly decreased by four alkaloids, whereas the activities of superoxide dismutase (SOD) and glutathione (GSH) were significantly increased. Four alkaloids effectively protected H9c2 cells against OGD-induced apoptosis by Hoechst/PI staining and flow cytometry assay. Western blotting results showed that the four alkaloids upregulated the expression ratio of Bcl-2/Bax and downregulated the expression levels of Cyt-C and cleaved caspase 3, which further supported the anti-cardiomyocyte apoptosis and antioxidative stress effect of Menispermi Rhizoma. Molecular docking confirmed that the four compounds were capable of binding to AKT1, MAPK1, EGFR, CASP3, and MAPK8 proteins, suggesting the protective effect of Menispermi Rhizoma on MI via PI3K/AKT, MAPK, and apoptosis pathways.Conclusion: Menispermi Rhizoma exerted cardioprotective effects through the effect characteristics: multiple-ingredient, multi-target, and multi-pathway. This research provided a reference for further mechanistic research on wider applications of Menispermi Rhizoma for MI treatment.

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New trends in the practical use of isoquinoline alkaloids as potential drugs applicated in infectious and non-infectious diseases

Tuzimski,

Petruczynik

2023

Biomedicine & Pharmacotherapy

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Analgesic bisbenzylisoquinoline alkaloids from the rhizoma of Menispermum dauricum DC

Cited by 14 publications

References 32 publications

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants

Mining Therapeutic Efficacy from Treasure Chest of Biodiversity and Chemodiversity: Pharmacophylogeny of Ranunculales Medicinal Plants

Integrated Serum Pharmacochemistry and Network Pharmacology Approach to Explore the Effective Components and Potential Mechanisms of Menispermi Rhizoma Against Myocardial Ischemia

New trends in the practical use of isoquinoline alkaloids as potential drugs applicated in infectious and non-infectious diseases

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