Analgesic compounds of Croton urucurana Baillon. Pharmaco‐chemical criteria used in their isolation

Peres, Marize Terezinha Lopes Pereira; Monachè, Franco Delle; Pizzolatti, Moacir Geraldo; Santos, Adair Roberto Soares; Beirith, Allessandra; Calixto, João Β.; Yunes, Rosendo A.

doi:10.1002/(sici)1099-1573(199805)12:3<209::aid-ptr215>3.3.co;2-g

Cited by 19 publications

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Section: Introductionmentioning

confidence: 99%

“…13,15,16 Fucoarabinogalactan, a polysaccharide, has been isolated from the gum exudate of C. urucurana. 17 In this study, we report the chemical composition, antioxidant 29 and antimicrobial activities of the essential oil obtained from the stem bark of Croton urucurana.…”

Section: Introductionmentioning

confidence: 99%

“…10 Many pharmacological effects of Croton urucurana have been described in literature, which include wound and ulcer healing, antidiarrhoeic, anticancer, intestinal anti-inflammatory, antioxidant and antirheumatic properties. [11][12][13][14]28 Peres et al 15 reported the antibacterial activity against Staphylococcus aureus and Salmonella typhimurium of the aqueous-EtOH extract, some fractions of the methanolic extract, catechin and acetyl aleuritolic acid obtained from C. urucurana.Previous phytochemical analysis of Croton urucurana have identified the presence of acetyl aleuritolic acid, catechin, gallocatechin, sonderianin, β-sitosterol and its glucoside, stigmasterol, campesterol and two novel clerodane diterpenes. 13,15,16 Fucoarabinogalactan, a polysaccharide, has been isolated from the gum exudate of C. urucurana.…”

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Chemical composition and evaluation of antibacterial and antioxidant activities of the essential oil of Croton urucurana Baillon (Euphorbiaceae) stem bark

Simionatto¹,

Bonani²,

Morel³

et al. 2007

J. Braz. Chem. Soc.

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O óleo essencial obtido a partir das cascas do caule de Croton urucurana Baillon (Euphorbiaceae) foi analisado por CG e CG-EM. 83 compostos foram identificados, sendo borneol (14,7%), acetato de bornila (5,2%), 1-isopropil-7-metil-4-metileno-1,3,4,5,6,8-hexaidro-2H-naftalen-4a-ol (14,7%), sesquicineol (10,5%) e epóxido de γ-gurjuneno (5,4%) os principais componentes. Para o óleo essencial bruto, foi determinada em 3,21 mg mL -1 a EC 50 no ensaio de atividade antioxidante frente ao radical livre DPPH. A fração do óleo essencial bruto que apresentou atividade antioxidante foi purificada por CCD sobre sílica gel. Análises de CG e CG-EM revelaram que α-bisabolol (38,3%), α-eudesmol (9,3%) e guaiol (8,2%) são os principais componentes da fração antioxidante. A EC 50 medida no teste frente ao DPPH foi de 1,05 mg mL -1 para a fração bioativa. Foi determinada a atividade antimicrobiana do óleo essencial bruto frente a sete bactérias Gram-positivas e Gram-negativas e três fungos. Os valores de CIM medidos variaram de 1,25 a 10,00 mg mL -1 .The essential oil obtained from the stem bark of Croton urucurana Baillon (Euphorbiaceae) was analysed by GC and GC-MS. 83 compounds were identified and borneol (14.7%), bornyl acetate (5.2%), 1-isopropyl-7-methyl-4-methylene-1,3,4,5,6,8-hexahydro-2H-naphthalen-4a-ol (14.7%), sesquicineole (10.5%) and γ-gurjunene epoxide (5.4%) were the main components. The EC 50 value of the crude essential oil in the DPPH free radical scavenging assay was 3.21 mg mL -1 . The fraction of the crude essential oil that presented antioxidant activity was purified by prep-TLC on silica gel. GC and GC-MS analysis revealed that α-bisabolol (38.3%), α-eudesmol (9.3%) and guaiol (8.2%) were the main components of the antioxidant fraction. The EC 50 value measured for the bioactive oil fraction in the DPPH assay was 1.05 mg mL -1 . The antimicrobial activity of the crude essential oil was assayed against seven Gram-positive and Gram-negative bacteria and three yeasts. Measured MIC values ranged from 1.25 to 10.00 mg mL -1 . Keywords:Croton urucurana, essential oil, antioxidant, DPPH assay, antimicrobial acticity IntroductionCroton (Euphorbiaceae) is one of the largest genera of flowering plants, with nearly 1,300 species of herbs, shrubs, and trees that are ecologically prominent and often important elements of secondary vegetation in the tropics and subtropics worldwide. Previous works reported that the essential oils from northeastern Brazilian Croton species, C. zenhtneri, C. nepetaefolius and C. argyrophylloides, exhibited good antioxidant activities. 9 Croton urucurana Baillon (Euphorbiaceae) is a tree commonly found in Paraguay, northern Argentina, southern Brazil, and Uruguay. Three different products from this species are used primarily in folk medicine: the red sap, the stem bark, and the gum exudate. 10 Many pharmacological effects of Croton urucurana have been described in literature, which include wound and ulcer healing, antidiarrhoeic, anticancer, intestinal anti-inflammatory, antioxidant and an...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Chemical composition and evaluation of antibacterial and antioxidant activities of the essential oil of Croton urucurana Baillon (Euphorbiaceae) stem bark

Simionatto¹,

Bonani²,

Morel³

et al. 2007

J. Braz. Chem. Soc.

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“…As cascas de C. urucurana, descrevem a presença de ácido acetilaleuritólico; dos flavonóides catequina e galocatequina; dos diterpenos clerodanos sonderianino, 12-epi-metilbarsbacoato e 15,16-epoxy-3,13(16)-clerodatrieno-2-ona; e dos esteróis: campesterol, stigmasterol, sitosterol e seu glicosídeo (PERES et al, 1997;PERES et al, 1998a;PERES et al, 1998b). A atividade antitumoral de vários flavonóides está atribuída a sua eficiência em inibir as enzimas topoisomerases I e II (SUKAR-DIMAN et al, 2000), diminuir a proliferação celular como consequência de sua ligação ao receptor de estrógeno (PRIMIANO et al, 2001), apresentar atividade inibidora de proteínas quinases (GAMETPAYRASTRE et al, 1999), e/ou induzir apoptose e liberação do citocromo c (LU et al, 2010).…”

Section: Avaliação Do Mecanismo De Morte Celularunclassified

“…Extratos de Croton urucurana foram descritivos por apresentarem atividades antibacterianas contra Staphylococcus aureus e Salmonella typhimurium (PERES et al, 1997), antifúgica contra fungos causadores de micoses de peles (GURGEL 2005), antimicrobiana e antioxidante (SIMIONATTO, 2007);anti-hemorrágica (ESMERALDINO, 2005) e analgésica (PERES et al, 1998b). OLIVEIRA et al 2008 relatam ações antibacteriana em uma triagem in vitro do látex e extratos de Croton urucurana.…”

Section: Introductionunclassified

Atividade Citotóxica Do Extrato De Croton Urucurana Baill Contra Linhagens De Células Leucêmicas Humanas U937 E Thp1

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Naturally occurring antinociceptive substances from plants

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Despite the progress that has occurred in recent years in the development of therapy, there is still a need for effective and potent analgesics, especially for the treatment of chronic pain. One of the most important analgesic drugs employed in clinical practice today continues to be the alkaloid morphine. In this review, emphasis will be given to the important contribution and the history of Papaver somniferum, Salix species, Capsicum species and Cannabis sativa in the development of new analgesics and their importance in the understanding of the complex pathways related to electrophysiological and molecular mechanisms associated with pain transmission. Recently discovered antinociceptive substances include alkaloids, terpenoids and flavonoid. Plant-derived substances have, and will certainly continue to have, a relevant place in the process of drug discovery, particularly in the development of new analgesic drugs.

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Analgesic compounds of Croton urucurana Baillon. Pharmaco‐chemical criteria used in their isolation

Cited by 19 publications

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Chemical composition and evaluation of antibacterial and antioxidant activities of the essential oil of Croton urucurana Baillon (Euphorbiaceae) stem bark

Chemical composition and evaluation of antibacterial and antioxidant activities of the essential oil of Croton urucurana Baillon (Euphorbiaceae) stem bark

Atividade Citotóxica Do Extrato De Croton Urucurana Baill Contra Linhagens De Células Leucêmicas Humanas U937 E Thp1

Naturally occurring antinociceptive substances from plants

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