Analgesic Drugs, XI: Diacyl Derivatives of Butyroguanamine

Kreutzberger, A.; Loch, M.

doi:10.1002/ardp.19863190316

Cited by 2 publications

(1 citation statement)

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“…s-Triazine derivatives also possess biological activities, such as anti-tubercular, 5 antitumor, 6 anti-cancer, 7 sedative, 8 anti-inflammatory 9 and anthelmintic 10 activities. In comparison with a previous publication on 1,3,5-triazinyl dithiocarbamates, 11 in which only one molecule of cyanuric chloride was involved in the reported molecules, a recent literature survey revealed that not a single method for the synthesis of bis(4,6-dichloro-1,3,5-triazin-2-yl) 1,2-hydrazine-1,2--dicarbodithioate 4a, 1,4-phenylenebis(carbamodithioate) 4b, (1,1'-biphenyl)-4,4'--diylbis(carbamodithioate) 4c, (sulfonyldi-4,1-phenylene)bis(carbamodithioate) 4d and 1,2-ethanediylbis(carbamodithioate) 4e, nor of bis{4,6-bis[(p-methoxyphenyl)amino]-1,3,5-triazin-2-yl} esters of the respective acids (4f-j) has been reported to date.…”

Section: Introductionmentioning

confidence: 99%

Studies on bioactive bis-1,3,5-triazinyl dithiocarbamates

Lunagariya

Desai

Shah

2007

JSCS

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The compounds bis(4,6-dichloro/bis[(p-methoxyphenyl)amino]-1,3,5--triazin-2-yl)1,2-hydrazine-1,2-dicarbodithioate/1,4-phenylenebis(carbamodithioate)/(1,1'-biphenyl)-4,4'-diylbis(carbamodithioate)/(sulphonyldi-4,1-phenylene)-bis(carbamodithioate/1,2-ethanediylbis(carbamothioate) 4a-j were synthesized by two different methods. In the first method (A) for the preparation of 4a-e, 2,4,6-trichloro-1,3,5-triazine 1 was condensed with diammonium 1,2-hydrazine-1,2-dicarbodithioate/1,4-phenylenebis(carbamodithioate)/(1,1'-biphenyl)-4,4'diylbis(carbamodithioate)/(sulphonyl-di-4,1-phenylene)-bis(carbamodithioate)/1,2-ethanediylbis(carbamodithioate) 3a-e to afford 4a-e which undergo reaction with p-methoxyaniline to afford 4f-j. In the second method (B) of preparation, 1 was condensed with p-methoxyaniline to yield 2 followed by the action of 3a-e to yield 4a-j. The structure of the newly synthesized compounds 4a-j was established on the basis of elemental analyses, as well as IR and 1 H-NMR spectroscopy. The antimicrobial activities of compounds 4a-j were determined by the cup-plate method against gram-positive bacteria, gram-negative bacteria and fungi. All the synthesized compounds showed significant antimicrobial activity.

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Section: Introductionmentioning

confidence: 99%