Analgesic effect and pharmacological mechanism of fentanyl and butorphanol in a rat model of incisional pain

Chen, Quan; Shang, You; Xu, Yong; Li, Ping; Liu, Guo-Li

doi:10.1016/j.jclinane.2015.08.010

Cited by 13 publications

(5 citation statements)

References 34 publications

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“…Butorphanol tartrate injection has an effect on κ Receptors, the effect on δ receptor is not obvious, and μ receptor has the dual effects of agonism and antagonism, and has the intensity effect on κ, δ, μ was 25:4:1. Due to this unique effect of butorphanol tartrate injection on opioid receptors, it has the following clinical application characteristics: 1) it has good analgesic effect of opioid drugs and little clinically significant respiratory inhibition; 2) it rarely causes decrease of gastrointestinal activity and spasm of smooth muscle; 3) rarely cause skin itching; 4) rarely causing urinary retention; 5) somatic dependence is extremely low [7] [8] [9] [10] [11]. Butorphanol tartrate injection has been widely used in analgesia treatment such as postoperative pain in China, and it is commonly administered by intravenous, intramuscular injection and nasal spray.…”

Section: Discussionmentioning

confidence: 99%

Study on Analgesia and Sedation of Butorphanol Tartrate Combined with Dexmedetomidine in Severe Cerebral Hemorrhage for Patients with Mechanical Ventilation

Ye¹,

Yang²,

Wang³

2022

ABB

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Objective: To analyze the effect and advantages in analgesia and sedation of butorphanol tartrate combined with dexmedetomidine in severe cerebral hemorrhage for patients with mechanical ventilation. Methods: 120 patients with severe cerebral hemorrhage requiring analgesia and sedation were randomly selected and divided into two groups: the control group (dexmedetomidine treatment group) and the test group (dexmedetomidine combined with butorphanol tartrate). Two groups of patients with different drugs were analyzed. Results: The average dose of dexmedetomidine (microgram) and the total adverse events (Times) in the test group were significantly lower than those in the control group within 48 hours (P < 0.05); The dose of Butorphanol in the test group was small, and the patients in the control group used other opioid analgesics to pump more significantly. Conclusion: Using butorphanol tartrate combined with dexmedetomidine can achieve the same sedative effect and enhance the analgesic effect as using dexmedetomidine alone with less dose of dexmedetomidine, and the clinical effect is significant. It also solves the problem that adverse reactions such as blood pressure change and bradycardia are easy to occur when using large dose of dexmedetomidine and the infusion speed is fast in clinical application, and significantly reduces the incidence of adverse reactions. It is worthy of clinical application.

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Section: Discussionmentioning

confidence: 99%

Study on Analgesia and Sedation of Butorphanol Tartrate Combined with Dexmedetomidine in Severe Cerebral Hemorrhage for Patients with Mechanical Ventilation

Ye¹,

Yang²,

Wang³

2022

ABB

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“…24 Butorphanol is a κ-opioid receptor agonist and a μ-opioid receptor antagonist and therefore has analgesic and sedative effects. 13 The elimination half-life in healthy animals is about 2,5 to 3,5 hours. 22 The duration of antinociception (plasma concentration of >45 ng/mL) is reported to be 2,7 ± 2,2 hours after IM administration.…”

Section: Discussionmentioning

confidence: 99%

How painful are cats after neutering – a field study using multimodal analgesia with intraperitoneal ropivacaine in a neuter-return program in feral cats

Heitzmann

Bettschart‐Wolfensberger

Torgerson

et al. 2022

SAT

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“…Fentanyl works synergistically with bupivacaine in reducing the pain threshold without increasing sympathetic and motor blockade. 15 There have been many studies that prove the effectiveness of opioid use in spinal anesthesia especially in CS surgery.…”

Section: Discussionmentioning

confidence: 99%

Low dose hyperbaric bupivacaine 5 mg combined with 50 mcg fentanyl for cesarean section in maternal heart disease

Isngadi

Hartono

Husodo

et al. 2019

APIC

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Background & Aims: Most of the women with cardiovascular diseases suffer from worsening of their clinical condition during pregnancy. It is caused by cardiovascular physiological changes during pregnancy and increased demand of oxygen-metabolic system. Spinal anesthesia is the most commonly used technique in cesarean section (CS) patients, but there are concerns about sudden hemodynamic decrease. We aimed to investigate the use of low dose hyperbaric bupivacaine 5 mg combined with 50 μg fentanyl for caesarean section in patient with heart disease.Methodology: This study is a retrospective study in 33 patients with maternal heart disease undergoing CS under low dose spinal anesthesia in Saiful Anwar Hospital Malang Indonesia from September 2017 until September 2018. The spinal regimen was administered with 5 mg bupivacaine heavy 0.5% combined with 50 μg fentanyl. We evaluated the hemodynamic preoperative, post injection of spinal anesthetics, postdelivery, and at the end of surgery. We also evaluated Bromage score, Apgar score of the baby, and satisfaction level by the obstetrician.Results: Combination of low dose spinal and opioid for the CS delivery show no significant hypotension effects. Hemodynamic stabilization was achieved. Furthermore, target blocked was reached well in all cases, no significant changes in Apgar score of the baby, and obstetrician satisfied with motor relaxation.Conclusion: Low dose spinal anesthesia using 5 mg of bupivacaine heavy 0.5% and adjuvant opioid fentanyl 50 μg can be successfully used for the performance of CS delivery satisfactory block, good fetal outcome, and impressive cardiovascular stability.Citation: Husodo DP, Isngadi I, Hartono R, Prasedya ES. Low dose hyperbaric bupivacaine 5 mg combined with 50 mcg fentanyl for cesarean section in maternal heart disease. Anaesth pain & intensive care 2019;23(3):274-278

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Analgesic effect and pharmacological mechanism of fentanyl and butorphanol in a rat model of incisional pain

Cited by 13 publications

References 34 publications

Study on Analgesia and Sedation of Butorphanol Tartrate Combined with Dexmedetomidine in Severe Cerebral Hemorrhage for Patients with Mechanical Ventilation

Study on Analgesia and Sedation of Butorphanol Tartrate Combined with Dexmedetomidine in Severe Cerebral Hemorrhage for Patients with Mechanical Ventilation

How painful are cats after neutering – a field study using multimodal analgesia with intraperitoneal ropivacaine in a neuter-return program in feral cats

Low dose hyperbaric bupivacaine 5 mg combined with 50 mcg fentanyl for cesarean section in maternal heart disease

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Analgesic effect and pharmacological mechanism of fentanyl and butorphanol in a rat model of incisional pain

Cited by 13 publications

References 34 publications

Study on Analgesia and Sedation of Butorphanol Tartrate Combined with Dexmedetomidine in Severe Cerebral Hemorrhage for Patients with Mechanical Ventilation

Study on Analgesia and Sedation of Butorphanol Tartrate Combined with Dexmedetomidine in Severe Cerebral Hemorrhage for Patients with Mechanical Ventilation

How painful are cats after neutering – a field study using multimodal analgesia with intraperitoneal ropivacaine in a ­neuter-return program in feral cats

Low dose hyperbaric bupivacaine 5 mg combined with 50 mcg fentanyl for cesarean section in maternal heart disease

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How painful are cats after neutering – a field study using multimodal analgesia with intraperitoneal ropivacaine in a neuter-return program in feral cats