1993
DOI: 10.1016/0041-0101(93)90399-4
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Analgesic effect evoked by low molecular weight substances extracted from Crotalus durissus terrificus venom

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Cited by 76 publications
(39 citation statements)
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“…The oral administration of drug referred as the convenient way, but it is assumed that enzymatic or chemical degradation of peptides in stomach or intestines will be making them less effective. However, contrary to the general idea, oral administration of the component of Crotalus durissus terrificus venom could induce analgesia [18]. Also oral utilization of hannalgesin caused the analgesic effects.…”
Section: Discussionmentioning
confidence: 75%
See 1 more Smart Citation
“…The oral administration of drug referred as the convenient way, but it is assumed that enzymatic or chemical degradation of peptides in stomach or intestines will be making them less effective. However, contrary to the general idea, oral administration of the component of Crotalus durissus terrificus venom could induce analgesia [18]. Also oral utilization of hannalgesin caused the analgesic effects.…”
Section: Discussionmentioning
confidence: 75%
“…Besides, anti-nociceptive and antiinflammatory effects of oral intoxication of cardiotoxin of snake venom are reported before [17]. Goirgi et al [18] refute the general view that digestive enzyme or chemical degradation will make venom biologically inactive in gastrointestinal tract.…”
Section: Introductionmentioning
confidence: 96%
“…For instance, antiflammins are nonapeptides derived from regions of high similarity in uteroglobin and lipocortins and do retain their anti-inflammatory activity (Cirino & Flower, 1987;Cabre et al, 1992). It is interesting to note that the crude venom of Crotalus durissus terrificus induces analgesia in mice when given orally (Giorgi et al, 1993). The identification of small crotapotinderived peptides which retain the anti-inflammatory activity of the parent protein and the delineation of their mechanism of action may widen the perspectives for the development of a new class of anti-inflammatory agents.…”
Section: Resultsmentioning
confidence: 99%
“…Unfortunately, the development was to be carried out by the company Theralpha that has closed (RM Kini, personal communication, 2014). Venom of the South American rattlesnake Crotalus durissus terrificus also has analgesic actions in experimental animals, even on oral administration (Giorgi et al, 1993). A 14-residue peptide with one disulphide bridge is involved.…”
Section: Still To Come?mentioning
confidence: 99%