Analgesic effect of extracts of Alpinia galanga rhizome in mice

Acharya, Sahana Devadasa; Ullal, P Sheetal Dinkar; Padiyar, Shivaraj; Rao, Yalla Durga; Upadhyaya, Kousthubha; Pillai, Durga; Raj, V. P. R. B. Ranjith

doi:10.3736/jcim20110116

Cited by 12 publications

(11 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The analgesic effect was assessed by placing the mice on a hot plate (Heidolph Me, Germany, Hei-standard Co. at 56ºC), the time between placing the mice on the hot plate and licking of fore or hind paw or/and jumping off from the surface was recorded as the response in seconds. Only mice that response to nociceptive response within 30 seconds was used in this study, the cut off time was 30 seconds to avoid any thermal injury to the paw (19), animals were used only once. The response was measured before (baseline) and at 15 minutes after injected of each drug doses.…”

Section: Methodsmentioning

confidence: 99%

“…In this experimental, mice divided into three groups, each group consist of 5 animals, group I injected with metoclopramide 10 mg/kg b.w i.p, group Π injected with xylazine 2mg/kg b.w i.p and group Ш injected with metoclopramide and xylazine at 10 mg/kg b.w i.p and 2mg/kg b.w i.p respectively. animals placed on hot plate before and 15 minutes after injection of drugs for calculate of latency time (19).…”

Section: Estimation Percentage Of Analgesia Of Pain In Subanalgesic Dmentioning

confidence: 99%

“…However, the combination of xylazine and metoclopramide was not evaluated in previous studies, so the purpose of current study was to qualitative and quantitative evaluation of the analgesic effect of metoclopramide and xylazine each alone or as a combination. the type of interaction between two drugs also evaluated in mice by using two models of acute pain induction, hot plate (central) and writhing response (peripheral) (19,20).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of the antinociceptive effect of xylazine and it’s interaction with metoclopramide in the acute pain model in mice

Shaban¹,

Al-Zubaidy²,

faris³

2020

IJVS

View full text Add to dashboard Cite

The study was designed to qualitative and quantitative evaluation of the antinociceptive effect of metoclopramide and xylazine each alone or as a concomitant administration in mice. Adult albino Swiss mice weighing 20-30 mg used in all experiments. By using the hot plate test, the individual analgesic dose (ED50) of metoclopramide and xylazine detected depending on the up and down method. Isobolographic analysis used to evaluate the type of interaction between two drugs at the ratio 0.5:0.5 of individual ED50 for each drug at the level of antinociception effect. Simultaneously administration of the double dose of individual ED50 and low doses (sedative, non-analgesic doses) of both drugs, also evaluated at the level of central and visceral analgesia using a hot plate and writhing response test respectively. The individual ED50 of xylazine and metoclopramide was 10.8 and 25.6mg/kg IP respectively. A synergistic interaction at the level of analgesia explored between two drugs at ratio 0.5:0.5 which represented as decreased in ED50 of metoclopramide and xylazine by 58.75 and 58.15% respectively. The animal suffered from only slight sedation and docile. Simultaneously IP administration of xylazine and metoclopramide at double dose of ED50 for each drug-induced significant increase in latency time of thermal response, as well as a significant decrease in writhes number, which induced by acetic acid in comparison with control groups. The percentage of analgesia at sub analgesic doses of a concomitant administration of both drugs was 100% in comparison with each drug alone. These results suggested safe and good use of both drugs in veterinary medicine.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Estimation Percentage Of Analgesia Of Pain In Subanalgesic Dmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the antinociceptive effect of xylazine and it’s interaction with metoclopramide in the acute pain model in mice

Shaban¹,

Al-Zubaidy²,

faris³

2020

IJVS

View full text Add to dashboard Cite

show abstract

“…To further examine the potential analgesic effect of silymarin and ketamine coadministration (by doublingthe ED 50s of both drugs given to mice), additional experiments were conducted to measure the analgesic effect of the combination 15 min after the administration by the thermal and chemical methods (Acharya et al, 2011;Le Bars et al, 2001). Acetic acid-induced writhing test in the mice,Thistest was conducted employing (Koster, 1959) method.…”

Section: Methodsmentioning

confidence: 99%

“…The purpose of the presentstudy was to explore the analgesic effect of silymarin and ketamine combination in mice. The models of pain induction used were the hot plateand chemical-induced writhing, which are predictive of acute pain responses with in-volvement of central and peripheral systems, respectively (Acharya et al, 2011;Barrot, 2012;Jain, Kulkarni, & Singh, 2001).…”

Section: Introductionmentioning

confidence: 99%

Isobolographic analysis of analgesic interactions of silymarin with ketamine in mice

Naser¹,

Albadrany²,

Shaaban³

2020

J Hellenic Vet Med Soc

View full text Add to dashboard Cite

The present study was undertaken to explore the analgesic effect of silymarin and ketamine alone or in combination in mice. Analgesia was measured by using a hot plate and the writhing test. The up-and-down method was used to determine the median effective analgesic dosages (ED50s) of silymarin and ketamine administered intraperitoneally (ip) either alone or together. The ED50s of both drugs were analyzed isobolographically to determine the type of pharmacological interaction between them. The analgesic ED50s for silymarin and ketamine in mice were 57.22 and 1.96 mg/kg, ip, respectively. Concomitant administration of the silymarin and ketamine at fixed ration (0.5:0.5) of their individual ED50s was 38.4 mg/kg and 1.28 mg/kg, ip, respectively. Silymarin and ketamine at fixed ration (1:1) of their individual ED50s were 47.54 mg/kg and 1.58 mg/kg, ip, respectively . Depending on the isobolographic analysis and calculating Y value, the type of pharmacological interaction between silymarin and ketamine at a ratio of 0.5:0.5 and 1:1 of their analgesic ED50 values of each drug , was antagonistic .In the writhing test the concomitant administration of silymarin and ketamine at 120mg/kg and 4mg/kg , ip, respectively reduce significantly the numbers of writhing in compare with silymarin120 mg/kg,ip and ketamine 4mg/kg, ip separately. The results suggest that the co-administration of silymarin and ketamine was ineffective to reduce the central pain while the concomitant administration of silymarin and ketamine was effective to reduce the visceral pain.

show abstract

Alpinia galanga (L.) Willd. (Zingiberaceae)

Akbar

2020

Handbook of 200 Medicinal Plants

View full text Add to dashboard Cite

Analgesic effect of extracts of Alpinia galanga rhizome in mice

Cited by 12 publications

References 7 publications

Evaluation of the antinociceptive effect of xylazine and it’s interaction with metoclopramide in the acute pain model in mice

Evaluation of the antinociceptive effect of xylazine and it’s interaction with metoclopramide in the acute pain model in mice

Isobolographic analysis of analgesic interactions of silymarin with ketamine in mice

Alpinia galanga (L.) Willd. (Zingiberaceae)

Contact Info

Product

Resources

About