Analgesic effect of histamine induced by intracerebral injection into mice

Abstract

Three methods were used to study the analgesic effect of intracerebral injection of histamine (Hi) on mice: the writhing test (acetic acid and phenylquinone), the electrical stimulation of the tail and the hot plate test. At doses higher than 2 micrograms, Hi inhibited the writhing syndrome significantly, and at doses of 10 micrograms or higher, Hi displayed a marked analgesic effect during both the electrical stimulation and hot plate methods. The saline injection produced only a negligible effect. Simultaneous application of Hi and 10 micrograms of diphenhydramine, pyrilamine or promethazine, apparently causing no analgesic effect from a single administration, caused a parallel shift of the dose-response curve of Hi to the right. ED50 of Hi was increased approximately 2, 2.8 and 3.8 times, respectively. However, cimetidine did not reveal any antagonistic effect on Hi-induced analgesia. Subcutaneously administered, 3 mg/kg of morphine augmented the analgesic effect of Hi. In accordance with this, pretreatment of naloxone (0.005 mg/kg) antagonized the analgesic action of Hi almost completely. When 5 mg/kg of leucine-enkephalin, less than the minimum effective dose, was given prior to Hi injection, the analgesic effect of Hi was enhanced. In addition, 10 and 20 micrograms of Hi increased the morphine analgesia markedly and parallel shifted the dose-response curve of morphine to the left.

H3 Receptors and Pain Modulation: Peripheral, Spinal, and Brain Interactions

“…Histamine, a pain-enhancing substance in the skin and spinal cord (Kajihara et al, 2010), reduces nociceptive transmission when injected directly into the brain (Glick and Crane, 1978;Chung et al, 1984;Bhattacharya and Parmar, 1985;Braga et al, 1992;Sibilia et al, 1992;Malmberg-Aiello et al, 1994;Thoburn et al, 1994). H 1 and H 2 receptors are thought to mediate this effect (Thoburn et al, 1994;Braga et al, 1996;Lamberti et al, 1996).…”

Anti-inflammatory effect of intraventricularly administered histamine in rats

“…Though still a matter of some controversy, its role as a putative central neurotransmitter is gaining acceptance. Centrally administered histamine has been recently reported to induce analgesia in mice [4]. These observations prompted us to investigate the effect of centrally administered histamine and histamine agonists on acute peripheral inflammation induced by carrageenin.…”

Antinociceptive mechanisms of Bunium persicum essential oil in the mouse writhing test: role of opioidergic and histaminergic systems

“…The cell bodies of this system are recognised only in the tuberomammillary nucleus (TMN) of the hypothalamus and their nerve fibres innervate all part of the CNS (Schwartz et al 1991). Several lines of evidence demonstrated that systemic or central injection of histamine or histamine agonists produces antinociception, suggesting the importance of the histaminergic system in pain regulation (Chung et al 1984). Peripheral histamine activates and sensitises itchspecific nociceptive C fibres (Schmelz et al 1997;Zendehdel et al 2012).…”