Analgesic effectiveness and safety of celecoxib versus non-opioid active controls after third molar surgery: A meta-analytical evaluation

Isiordia-Espinoza, Mario Alberto; Franco-González, María Andrea; Alonso-Castro, Ángel Josabad; Torre, Lorenzo Franco‐de la

doi:10.1016/j.jormas.2021.06.015

Cited by 8 publications

(21 citation statements)

References 45 publications

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“…The Cochrane Collaboration's risk of bias tool was used 1,2 . The clinical trials with a high risk of bias (a red ball) were excluded from the qualitative and quantitative assessments 1,2 .…”

Section: Methodsmentioning

confidence: 99%

“…1,2 The clinical trials with a high risk of bias (a red ball) were excluded from the qualitative and quantitative assessments. 1,2 This stage included the participation of two blinded independent evaluators and the differences were resolved with the participation of a third researcher. [13][14][15]…”

Section: Assessment Of Biasmentioning

confidence: 99%

“…Postoperative use of nonsteroidal anti‐inflammatory drugs (NSAIDs) following third molar surgery is common 1,2 . These agents are employed to control the most habitual post‐surgical complications (i.e., postoperative pain, facial inflammation and trismus) 1,3,4 .…”

Section: Introductionmentioning

confidence: 99%

“…These agents are employed to control the most habitual post‐surgical complications (i.e., postoperative pain, facial inflammation and trismus) 1,3,4 . Most NSAIDs are used to control low to moderate pain and when this symptom is severe, ketorolac can be used 1,2 …”

Section: Introductionmentioning

confidence: 99%

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Postoperative administration of ketorolac compared to other drugs for pain control after third molar surgery: A meta‐analysis of double‐blind, randomized, clinical trials

Isiordia-Espinoza

Alonso-Castro

Serafín-Higuera

et al. 2022

Brit J Clinical Pharma

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The aim of this study was to evaluate the analgesic effectiveness and adverse reactions of ketorolac in comparison with other drugs when administered postoperatively after third molar surgery.Methods: PubMed and Google Scholar were utilized to search for articles comparing the efficacy and safety of ketorolac and other analgesic agents after third molar surgery. Data from papers with a lower risk of bias were recorded. The overall evaluation of analgesia onset, general and subgroup evaluation of the number of patients requiring rescue analgesic medication, general and subgroup assessment of the study medication (satisfaction on the study drugs), and the overall estimation of adverse effects were performed using the Review Manager Software 5.3 to analyse the data and obtain the meta-analysis plot. Results:The subgroup evaluation of the study medication showed that patients who

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Section: Methodsmentioning

confidence: 99%

Section: Assessment Of Biasmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Postoperative administration of ketorolac compared to other drugs for pain control after third molar surgery: A meta‐analysis of double‐blind, randomized, clinical trials

Isiordia-Espinoza

Alonso-Castro

Serafín-Higuera

et al. 2022

Brit J Clinical Pharma

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“…Several drugs have been used for postoperative complications control following third molar removal [ 1 , 2 , 3 , 4 ]. The most used drugs are non-steroidal anti-inflammatory drugs (NSAIDs), opioid analgesics, and corticosteroids [ 5 , 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Methylprednisolone Compared to Other Drugs for Pain, Swelling, and Trismus Control after Third Molar Surgery: A Meta-Analysis

González-Morelos¹,

Torre²,

Franco-González³

et al. 2022

Healthcare

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The purpose of this systematic review and meta-analysis was to assess the efficacy of methylprednisolone compared to other drugs to control postoperative complications following third molar surgery. PubMed and Google Scholar were used for article searching. Thereafter, the trials meeting the selection criteria and with high methodological quality, according to the Cochrane Collaboration’s risk of bias tool, were included in this study. The inverse variance test and mean difference using the Review Manager Software 5.3 for Windows were used to carry out data analysis. Qualitative analysis shows that methylprednisolone is more effective than NSAIDs, but inferior to dexamethasone, for controlling postoperative complications after third molar removal. The quantitative analysis showed no statistical difference for pain control, while trismus evaluation showed a statistical difference after 7 postoperative days in favor of methylprednisolone, when compared to other drugs. In conclusion, methylprednisolone was more effective for trismus control compared to other drugs after lower third molar surgery.

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Comparing pre- and postoperative etoricoxib administration versus only postoperative on third molar extraction sequelae and oral health quality of life: a prospective quasi-experimental study

La Rosa,

Consoli,

Abiad

et al. 2024

Clin Oral Invest

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Objectives This study aimed to compare the impact of pre- and postoperative etoricoxib administration versus only postoperative on third molar extraction sequelae and oral health quality of life. Materials and methods This prospective quasi experimental study involved 56 patients, divided into a study group receiving preemptive etoricoxib 120 mg before surgery and postoperative etoricoxib 120 mg (n = 28), and a control group receiving preemptive placebo before surgery and postoperative etoricoxib 120 mg (n = 28). Follow-up assessments were conducted at 3- and 7-days post-surgery, recording swelling, trismus, and adverse events. Patients rated perceived pain using the visual analog scale (VAS) and completed an oral health-related quality of life (OHRQoL) questionnaire at specified intervals. Statistical analysis employed non-parametric tests (i.e., the Mann–Whitney test, Friedman test, and Wilcoxon sign test) with P < 0.05. Results Significantly lower VAS scores were reported in the study group throughout the follow-up period (P < 0.05). Pharmacological protocol did not have a significant impact on postoperative edema and trismus (P > 0.05). However, double etoricoxib intake significantly improved postoperative quality of life on day 3 after surgery (P < 0.05). Conclusions Pre- and postoperative etoricoxib 120 mg intake in third molar surgery reduced postoperative pain and enhanced postoperative quality of life on day 3 after surgery. Importantly, it was equally effective in managing swelling and trismus compared to exclusive postoperative intake. Clinical Relevance Preemptive etoricoxib use may decrease patient discomfort following impacted mandibular third molar extraction.

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Analgesic effectiveness and safety of celecoxib versus non-opioid active controls after third molar surgery: A meta-analytical evaluation

Cited by 8 publications

References 45 publications

Postoperative administration of ketorolac compared to other drugs for pain control after third molar surgery: A meta‐analysis of double‐blind, randomized, clinical trials

Postoperative administration of ketorolac compared to other drugs for pain control after third molar surgery: A meta‐analysis of double‐blind, randomized, clinical trials

Efficacy of Methylprednisolone Compared to Other Drugs for Pain, Swelling, and Trismus Control after Third Molar Surgery: A Meta-Analysis

Comparing pre- and postoperative etoricoxib administration versus only postoperative on third molar extraction sequelae and oral health quality of life: a prospective quasi-experimental study

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