Analgesic Effects of<i> Cnidium officinale</i> Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models

Lim, Eun Yeong; Kim, Jae Goo; Lee, Jaekwang; Lee, Chang-Ho; Shim, Jaewon; Kim, Yun Tai

doi:10.1155/2019/9698727

Cited by 13 publications

(8 citation statements)

References 35 publications

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“…For example, Cnidium officinale is traditionally used in Korea to attenuate pain and increase stamina [ 90 ]. Postoperative, neuropathic, and menopausal pain models confirmed that C. officinale extracts attenuate hypersensitivity [ 91 ]. Further, in the rat spared nerve injury model, C. officinale inhibited the induction of the proinflammatory cytokines and calpain-3 in dorsal root ganglion neurons, which may be due to its CGA and ferulic acid contents.…”

Section: Effects Of Chlorogenic Acid In Inflammatory and Neuropathic mentioning

confidence: 99%

Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation

Bağdaş

Gül

Meade

et al. 2020

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Background: Natural phenolic compounds in medicinal herbs and dietary plants are antioxidants which play therapeutic or preventive roles in different pathological situations, such as oxidative stress and inflammation. One of the most studied phenolic compounds in the last decade is chlorogenic acid (CGA), which is a potent antioxidant found in certain foods and drinks. Objective: This review focuses on the anti-inflammatory and antinociceptive bioactivities of CGA, and the putative mechanisms of action are described. Ethnopharmacological reports related to these bioactivities are also reviewed. Materials and Methods: An electronic literature search was conducted by authors up to October 2019. Original articles were selected. Results: CGA has been shown to reduce inflammation and modulate inflammatory and neuropathic pain in animal models. Conclusion: The consensus of the literature search was that systemic CGA may facilitate pain management via bolstering antioxidant defenses against inflammatory insults.

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Section: Effects Of Chlorogenic Acid In Inflammatory and Neuropathic mentioning

confidence: 99%

Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation

Bağdaş

Gül

Meade

et al. 2020

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“…Cinnamate is also known as ferulic acid [ 40 ]. Ferulic acid (an active compound from COE) inhibited the DRG inflammatory response in a rat model of nerve injury [ 41 ]. However, the potential molecular mechanisms of palmitic acid and cinnamate in LDHs remain unclear.…”

Section: Discussionmentioning

confidence: 99%

Yaobishu Regulates Inflammatory, Metabolic, Autophagic, and Apoptosis Pathways to Attenuate Lumbar Disc Herniation

Zang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Objective. Here, we aimed to explore the main mechanism of Yaobishu (YBS) in lumbar disc herniation (LDH). Methods and Results. Eighteen compounds that might act on LDH were obtained through a combination of network pharmacology prediction and identification by high-performance liquid chromatography-mass spectrometry. The key compounds were palmitic acid and trans-4-hydroxy-3-methoxycinnamate (cinnamate). KEGG analysis demonstrated that palmitic acid target genes mainly regulate the PPAR signaling pathway, Ras signaling pathway, and fatty acid metabolism. Cinnamate target genes were primarily involved in chemical carcinogenesis-receptor activation, lipid and atherosclerosis, the HIF-1 signaling pathway, and nitrogen metabolism. The rat LDH model was constructed using autologous nucleus pulposus tissue implantation. Differential expression gene (DEGs) related to metabolism (CDKN1A and UHRF1), inflammation (S100A9 and SOCS3), autophagy (DCN and LEPR), and apoptosis (CTSW and BCL2A1) in dorsal root ganglion (DRG) tissues of the control and LDH groups was evaluated by RNA-Seq. TNF-α stimulated DRG neuronal cells were used to establish an in vitro LDH model. YBS, palmitic acid, and cinnamate reduced the expression of substance P, CGRP, S100A9, CTSW, and cleaved caspase-3, while enhancing the expression of CDKN1A, UHRF1, PCNA, Ki67, SOCS3, DCN, LEPR, and BCL2A1, as well as telomerase activity. Pearson’s correlation analysis confirmed that DCN was positively correlated with BCL2A1, indicating that autophagy might be negatively correlated with apoptosis in LDH. YBS, palmitic acid, and cinnamate reduced the Siegal neurological score and serum IL-1β and IL-18 levels, while increasing changes in the hind paw mechanical withdrawal threshold. The RNA-Seq results further showed that YBS downregulated S100A9 and CTSW expression, while upregulating SOCS3, CDKN1A, UHRF1, DCN, LEPR, and BCL2A1 expression. Conclusion. YBS and its compounds, palmitic acid, and cinnamate, attenuated LDH by regulating the inflammatory, metabolic, autophagic, and apoptotic pathways. Our results might improve the theoretical and experimental basis for clinical applications of LDH disease treatment.

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“…The relative mRNA levels were calculated from the obtained Ct values according to the ΔΔCt method. The Ct values were normalized to elongation factor 1α (EF) mRNA, 24) which is encoded by a house-keeping gene and used as an internal control. The normalized mRNA lev-…”

Section: Purification Of Constituents From the Rhizome Of Cnidium Omentioning

confidence: 99%

Comparative Analysis of Anti-inflammatory Activity of the Constituents of the Rhizome of <i>Cnidium officinale</i> Using Rat Hepatocytes

Ningsih

Okuyama

et al. 2020

Biological & Pharmaceutical Bulletin

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The rhizome of Cnidium officinale (Umbelliferae) (known as Senkyu in Japan; COR) has been used as a crude drug in Japanese Kampo formulas, such as Jumihaidokuto (to treat eczema and urticaria) and Kakkontokasenkyushin'i (to treat rhinitis). COR contains phthalides, which are thought to be potent principal constituents. Few studies have been reported about the comparison of anti-inflammatory activity of COR constituents. We aimed to identify the constituents in COR and compare their anti-inflammatory activity. COR was extracted with methanol and fractionated into ethyl acetate (EtOAc)-soluble, n-butanol-soluble, and water-soluble fractions. Primary cultured rat hepatocytes were used to assess anti-inflammatory activity by monitoring the interleukin (IL)-1β-induced production of nitric oxide (NO), an inflammatory mediator. The EtOAc-soluble fraction significantly suppressed NO production without showing cytotoxicity in IL-1βtreated hepatocytes, whereas the n-butanol-soluble fraction showed less potency, and the water-soluble fraction did not significantly affect the NO levels. Four constituents were isolated from the EtOAc-soluble fraction and identified as senkyunolide A, (3S)-butylphthalide, neocnidilide, and cnidilide. Among these phthalides and (Z)-ligustilide, senkyunolide A and (Z)-ligustilide efficiently suppressed NO production in hepatocytes, whereas the others showed less potency in the suppression of NO production. Furthermore, senkyunolide A decreased the levels of the inducible nitric oxide synthase (iNOS) protein and mRNA, as well as the levels of mRNAs encoding proinflammatory cytokines (e.g., tumor necrosis factor α) and chemokine CC motif ligand 20. These results suggest that senkyunolide A may cause the anti-inflammatory and hepatoprotective effects of COR by suppressing the genes involved in inflammation.

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Analgesic Effects of Cnidium officinale Extracts on Postoperative, Neuropathic, and Menopausal Pain in Rat Models

Cited by 13 publications

References 35 publications

Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation

Pharmacologic Overview of Chlorogenic Acid and its Metabolites in Chronic Pain and Inflammation

Yaobishu Regulates Inflammatory, Metabolic, Autophagic, and Apoptosis Pathways to Attenuate Lumbar Disc Herniation

Comparative Analysis of Anti-inflammatory Activity of the Constituents of the Rhizome of <i>Cnidium officinale</i> Using Rat Hepatocytes

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