Analgesic efficacy of intra-articular morphine in experimentally induced radiocarpal synovitis in horses

Lindegaard, Claus; Thomsen, Maj Halling; Larsen, Stig; Andersen, Pia Haubro

doi:10.1111/j.1467-2995.2009.00521.x

Cited by 94 publications

(105 citation statements)

References 58 publications

(146 reference statements)

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“…Pain assessment and lameness scoring using the AAEP lameness scale (the scale ranges from 0 to 5, with 0 being no perceptible lameness, and 5 being most extreme with little or no weight bearing) [33] was performed by two observers (SMA, AMLV) blinded to each other’s grading. Pain was assessed by the previously described composite measure pain scale [34], which is based on six behavioural categories: gross pain behaviour, weight bearing, head position relative to the withers, location in stall, response to open door, and response to approach from the observer, as well as on an ‘overall’ subjective pain score. Point scores for all behavioural categories were totalled to yield a final pain score ranging from 0 to 23.…”

Section: Methodsmentioning

confidence: 99%

Changes in concentrations of haemostatic and inflammatory biomarkers in synovial fluid after intra-articular injection of lipopolysaccharide in horses

et al. 2017

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BackgroundSeptic arthritis is a common and potentially devastating disease characterized by severe intra-articular (IA) inflammation and fibrin deposition. Research into equine joint pathologies has focused on inflammation, but recent research in humans suggests that both haemostatic and inflammatory pathways are activated in the joint compartment in arthritic conditions. The aim of this study was to characterize the IA haemostatic and inflammatory responses in horses with experimental lipopolysaccharide (LPS)-induced joint inflammation. Inflammation was induced by IA injection of LPS into one antebrachiocarpal joint of six horses. Horses were evaluated clinically with subjective grading of lameness, and blood and synovial fluid (SF) samples were collected at post injection hours (PIH) -120, −96, −24, 0, 2, 4, 8, 16, 24, 36, 48, 72 and 144. Total protein (TP), white blood cell counts (WBC), serum amyloid A (SAA), haptoglobin, iron, fibrinogen, thrombin-antithrombin (TAT) and d-dimer concentrations were assessed in blood and SF.ResultsIntra-articular injection of LPS caused local and systemic signs of inflammation including increased rectal temperature, lameness and increased joint circumference and skin temperature. Most of the biomarkers (TP, WBC, haptoglobin, fibrinogen and TAT) measured in SF increased quickly after LPS injection (at PIH 2–4), whereas SAA and d-dimer levels increased more slowly (at PIH 16 and 144, respectively). SF iron concentrations did not change statistically significantly. Blood WBC, SAA, haptoglobin and fibrinogen increased and iron decreased significantly in response to the IA LPS injection, while TAT and d-dimer concentrations did not change. Repeated pre-injection arthrocenteses caused significant changes in SF concentrations of TP, WBC and haptoglobin.ConclusionSimilar to inflammatory joint disease in humans, joint inflammation in horses was accompanied by an IA haemostatic response with changes in fibrinogen, TAT and d-dimer concentrations. Inflammatory and haemostatic responses were induced simultaneously and may likely interact. Further studies of interactions between the two responses are needed for a better understanding of pathogenesis of joint disease in horses. Knowledge of effects of repeated arthrocenteses on levels of SF biomarkers may be of value when markers are used for diagnostic purposes.

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Section: Methodsmentioning

confidence: 99%

Changes in concentrations of haemostatic and inflammatory biomarkers in synovial fluid after intra-articular injection of lipopolysaccharide in horses

et al. 2017

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“…Nevertheless, several medications are used intra-articularly, such as COs, hyaluronic acid (HA)/sodium hyaluronate (SH)/hyaluronate (HA), polysulfated glycosaminoglycans, sodium pentosan polysulfate, sodium chondroitin sulfate, somatostatin, N-acetyl- D-glucosamine, radiation synovectomy, dextrose prolotherapy, keratan sulfate orgotein, saline for washout, silicone, mucopolysaccharide polysulfuric acid ester, chloroquine, lactic acid solution, amikacin, gentamicin morphine, autologous serum, platelet-rich plasma, mesenchymal stem cells derived from bone marrow or adipose stromal vascular fraction, gene therapy using IL-1 antagonists, and ethanol. In addition, studies have used a topical liposomal formulation that contains diclofenac, lyophilized products from green-lipped mussel, extracorporeal shockwave, acupuncture, magnetic field, transcutaneous electrical nerve stimulation, therapeutic ultrasound, laser therapy, manual therapy, aquatic physical therapy and nutraceuticals food suplement (Uthman et al 2003;Caron 2005;Revenaugh 2005;Carmona et al 2007;Frisbie et al 2009;Goodrich and Nixon 2006;Santos et al 2009;Lindegaard et al 2010;Cayzer et al 2011;Kawcak et al 2011;Baccarin et al, 2012;McIIwraith et al 2011McIIwraith et al , 2012aCarmalt et al 2012;Lamas et al 2012;Vanderweerd et al 2012;Frisbie et al 2013;King et al 2013;Neuman et al 2013;Ferris et al 2014;Koenig et al 2014, de Grawn et al 2016. The use of controlled physical activity, as a complementary treatment, possibly improves the comfort level of the horse and decreases the inflammatory process (Kerbyson et al 2013).…”

Section: Possible Treatmentsmentioning

confidence: 99%

Osteoarthritis in horses - Part 2: a review of the intra-articular use of corticosteroids as a method of treatment

Souza

2016

Braz. arch. biol. technol.

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“…The discovery of opioid receptors in the equine synovial membrane (Sheehy et al, 2001) makes it plausible that intraarticular (IA) administration of opioid drugs may have analgesic and anti-inflammatory properties in horses similar to those demonstrated in other species (Lindegaard et al, 2010); especially in human. Tramadol, a weak µ agonist, interferes with the neuronal release and reuptake of serotonin and norepinephrine in the descending inhibitory pathways like α 2 adrenoceptor agonists.…”

Section: Introductionmentioning

confidence: 99%

Effects of Intraarticular Tramadol Administration on Biochemical and Cytological Properties of Equine Synovial Fluid: Comparison with Lidocaine

Jahromi¹

2011

American Journal of Pharmacology and Toxicology

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Problem statement: Diagnostic and therapeutic arthroscopic surgeries are procedures performed quite frequently in equine practice; and are considered to cause some degree of postoperative pain. The aim of the present study was to evaluate the equine synovial fluid biochemical and cytological changes following intra-articular administration of tramadol as a potential analgesic. Approach: Six adult healthy donkeys were selected after clinical examination. Synovial fluid samples were taken from both middle carpal joints after routine preparation. Tramadol 2 mg kg −1 and 100 mg lidocaine 2% were administered to the right and left joints respectively. Synovial fluid collection from the joints was performed at 12, 24, 48-192 h after medication. Cytological examination, total protein, glucose, specific gravity, Alkaline Phosphates (ALP), Aspartate Aminotransferase (AST), Lactate Dehydrogenase (LDH), viscosity and quality of mucin clot were measured. Comparison of treatments was performed by nonparametric sign test and Wilcoxon rank sum test. Significance level was set to p ≤ 0.05. Results: Neither detectable lameness nor special side effect was observed throughout the study. Mucin clot quality test and viscosity, the amount of total nucleated cell count, glucose, ALP and LDH revealed no significant differences between various sampling times between the tramadol and lidocaine groups (P>0.05). Neutrophil count, total protein, specific gravity and AST activity were significantly different. Conclusion/Recommendations: Despite the slightly different results compared to the lidocaine, it seems that the injection of tramadol into the middle carpal joint has no adverse effects on the synovial fluid composition in this joint and it can be considered a good analgesic after arthroscopic surgery with the lowest side effects in horses.

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Analgesic efficacy of intra-articular morphine in experimentally induced radiocarpal synovitis in horses

Cited by 94 publications

References 58 publications

Changes in concentrations of haemostatic and inflammatory biomarkers in synovial fluid after intra-articular injection of lipopolysaccharide in horses

Changes in concentrations of haemostatic and inflammatory biomarkers in synovial fluid after intra-articular injection of lipopolysaccharide in horses

Osteoarthritis in horses - Part 2: a review of the intra-articular use of corticosteroids as a method of treatment

Effects of Intraarticular Tramadol Administration on Biochemical and Cytological Properties of Equine Synovial Fluid: Comparison with Lidocaine

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