Analgesic Efficacy of Low Intensity Laser Therapy in a Monosodium Iodoacetate-induced Osteoarthritic Rat Model

Kim, Gyeyeop; Kim, Eunjung

doi:10.1589/jpts.25.309

Cited by 5 publications

(9 citation statements)

References 32 publications

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“…In the present study, the OA animals that received PBM at 18 J/cm 2 showed pain reduction from the fourth session. Other studies also observed late effects of PBM: day 9, day 14 and after 6 weeks . The PBM may decrease pain and inflammation caused by the joint injury, with consequent sensitization reduction .…”

Section: Discussionmentioning

confidence: 88%

“…Mechanisms that reduce pain through laser therapy are not yet fully understood. However, one of the possible explanations for pain relief is the resolution of the inflammatory process, resulting in decreased edema and synovitis. Another possibility is that the PBM may affect the conduction rate and the nervous fiber action potential amplitude .…”

Section: Discussionmentioning

confidence: 99%

“…Knee osteoarthritis (OA) is characterized by the presence of pain and stiffness that interfere with the articular function, leading to a significant loss of life quality . OA treatment is based on changes in the individual lifestyle, together with pharmacological and physiotherapeutic interventions.…”

Section: Introductionmentioning

confidence: 99%

“…OA treatment is based on changes in the individual lifestyle, together with pharmacological and physiotherapeutic interventions. These actions aim to reduce pain and inflammation in order to increase joint function . The photobiomodulation therapy (PBM), through the use of low intensity laser therapy, is a promising alternative for the OA treatment.…”

Section: Introductionmentioning

confidence: 99%

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Photobiomodulation therapy in knee osteoarthritis reduces oxidative stress and inflammatory cytokines in rats

Yamada

Bobinski

Martins

et al. 2019

Journal of Biophotonics

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Knee osteoarthritis (OA) is a chronic disease that causes pain and gradual degeneration of the articular cartilage. In this study, MIA‐induced OA knee model was used in rats to test the effects of the photobiomodulation therapy (PBM). We analyzed the inflammatory process (pain and cytokine levels), and its influence on the oxidative stress and antioxidant capacity. Knee OA was induced by monosodium iodoacetate (MIA) intra‐articular injection (1.5 mg/50 μL) and the rats were treated with eight sessions of PBM 3 days/week (904 nm, 6 or 18 J/cm2). For each animal, mechanical and cold hyperalgesia and spontaneous pain were evaluated; biological analyses were performed in blood serum, intra‐articular lavage, knee structures, spinal cord and brainstem. Cytokine assays were performed in knee, spinal cord and brainstem samples. The effects of the 18 J/cm2 dose of PBM were promising in reducing pain and neutrophil activity in knee samples, together with reducing oxidative stress damage in blood serum and spinal cord samples. PBM improved the antioxidant capacity in blood serum and brainstem, and decreased the knee pro‐inflammatory cytokine levels. Our study demonstrated that PBM decreased oxidative damage, inflammation and pain. Therefore, this therapy could be an important tool in the treatment of knee OA.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Photobiomodulation therapy in knee osteoarthritis reduces oxidative stress and inflammatory cytokines in rats

Yamada

Bobinski

Martins

et al. 2019

Journal of Biophotonics

View full text Add to dashboard Cite

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“…The positive results observed with pain control may also contribute to its clinical application in therapy 22 ) . Many studies have focused on the effects of low-intensity laser therapy on the mechanisms of wound healing or the mechanical laser therapy approach, but few studies have shown a correlation with pain relief 9 , 20 , 23 , 24 , 25 ) . This study found that LILT suppressed c- fos expression, which is known as a marker of pain, by the spinal cord.…”

Section: Discussionmentioning

confidence: 99%

The effect of low-intensity laser therapy (LILT) on cutaneous wound healing and pain relief in rats

Koo

Yong

2015

J Phys Ther Sci

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[Purpose] This study examined the impact of low-intensity laser therapy on wound healing and pain control using a rat cutaneous wound model. [Subjects and Methods] Twenty-four adult male Sprague-Dawley rats (between 220−240 g, 7 weeks) were used in this study. The rats were anesthetized and a circular fragment of skin was removed from the dorsal region of the back by a punch with an 8-mm diameter. The animals were randomly divided into 6 groups, Groups C 1, C 3, and C 5, control groups, received no laser treatment. Groups T 1, T 3, and T 5 received laser treatment for 20 min per day for 1, 3 and 5 days, respectively. Lumbar spine and dorsal skin were extracted and processed using western blot analysis. [Results] Periodical observation showed increases in NGF expression on the skin, and decreases in c-fos expression by the spinal cord in the treatment groups compared to the control group. [Conclusion] The present findings suggest that low-intensity laser therapy could be used as an effective therapy for wound healing and pain relief, and could be further used as a clinical approach for treating cutaneous wounds.

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A systematic review and network meta-analysis on the optimal wavelength of low-level light therapy (LLLT) in treating knee osteoarthritis symptoms

Fan,

Li,

Wong

et al. 2024

Aging Clin Exp Res

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Objectives To compare the efficacy of the various wavelengths of low-level light therapy (LLLT) in alleviating knee pain, dysfunction, and stiffness in patients with knee osteoarthritis (KOA), and to compare the effectiveness of LLLT versus sham treatment in reducing knee pain, dysfunction, and stiffness. Methods PubMed, Web of Science, EMBASE, and Cochrane Library were searched from inception to 12 December 2023. Randomized controlled trials that assessed the effects of different wavelengths of LLLT on alleviating pain of patients with KOA were included. A conventional meta-analysis and network meta-analysis were preformed, and standardized mean differences (SMD) with 95% confidence interval (CI) were calculated. Results Thirteen studies involving 673 participants with KOA met inclusion criteria. Overall, LLLT was superior to sham LLLT for relieving pain (SMD = 0.96, 95% CI 0.31–1.61) but not for improving function (SMD = 0.21, 95% CI − 0.11 to 0.53) or stiffness (SMD = 0.07, 95% CI − 0.25 to 0.39). Surface under the cumulative ranking curve (SUCRA) value ranking showed the most effective wavelength of LLLT in reducing KOA pain was 904–905 nm (SUCRA, 86.90%), followed by multi-wavelengths (MWL) (SUCRA, 56.43%) and 785–850 nm (SUCRA, 54.97%). Compared to sham LLLT, L2 (SMD = 1.42, 95% CI = 0.31–2.53) and L1 (SMD = 0.82; 95% CI = 0.11–1.50) showed a significant reduction in KOA pain. However, MWL (SMD = 0.83; 95% CI = − 0.06 to 1.72) showed similar KOA pain reduction compared to sham LLLT. The certainty of evidence showed that the quality of evidence regarding the effectiveness of overall LLLT versus sham, and 904–905 nm versus sham were low, while the quality of evidence for MWL versus sham, and 785–850 nm versus sham was very low. Conclusion While the 904–905 nm wavelength showed potential benefits in reducing KOA pain, the overall quality of the evidence was low. LLLT with 904–905 nm or 785–850 nm wavelengths yielded significantly better reduction in KOA pain compared to sham LLLT, but further high-quality research is warranted to validate these findings.

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Analgesic Efficacy of Low Intensity Laser Therapy in a Monosodium Iodoacetate-induced Osteoarthritic Rat Model

Cited by 5 publications

References 32 publications

Photobiomodulation therapy in knee osteoarthritis reduces oxidative stress and inflammatory cytokines in rats

Photobiomodulation therapy in knee osteoarthritis reduces oxidative stress and inflammatory cytokines in rats

The effect of low-intensity laser therapy (LILT) on cutaneous wound healing and pain relief in rats

A systematic review and network meta-analysis on the optimal wavelength of low-level light therapy (LLLT) in treating knee osteoarthritis symptoms

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