Analgesic opioid use in a health-insured epilepsy population during 2012: Response to Derakhshan

Wilner, Andrew N.; Sharma, Bal Krishan; Thompson, Amy R.; Krueger, Andrew

doi:10.1016/j.yebeh.2016.04.016

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2017

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“…The most pertinent statistical data concerning the frequency of the need for opioids in successfully preventing migraine and migrainerelated epilepsy (migralepsy) was published by Wilner et al in 2016 [3][4][5]. Having identified epilepsy and migraine as comorbid conditions, the authors findings among 10, 271 patients with epilepsy, compared to that in 20,542 controls, indicated the need for prescription opioid in 26% of an insured population with epilepsy, versus 18% in a matched control population (p<0.001).…”

Section: Review Of the Literaturementioning

confidence: 99%

A Therapeutic Connection between Migraine and Epilepsy

Derakhshan¹

2017

J Neurol Neurophysiol

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The connection between the episodic conditions, migraine and epilepsy, is widely acknowledged but the mechanism involved is subject to debates. Similarly, the role of maintenance opioid in preventing migraine and related entities is well known but few reports exist on the prophylactic use of opioids in preventing both migraine and epilepsy (migralepsy) proven refractory to the use of conventional anticonvulsants. Here, I provide details of a patient with refractory migralepsy who responded favourably to daily scheduled opioid, with eventual complete remission of headaches and seizures at a high dose of oxycodone.

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Section: Review Of the Literaturementioning

confidence: 99%