Healthcare costs for CIDP patients are substantial, with a large burden in pharmacy usage. Studies are needed to determine optimal long-term treatment strategies for CIDP, particularly related to IVIg.

The genus Corynebacterium encompasses many species of biotechnological, medical or veterinary significance. An important characteristic of this genus is the presence of mycolic acids in their cell envelopes, which form the basis of a protective outer membrane (mycomembrane). Mycolic acids in the cell envelope of Mycobacterium tuberculosis have been associated with virulence. In this study, we have analysed the genomes of 140 corynebacterial strains, including representatives of 126 different species. More than 50% of these strains were isolated from clinical material from humans or animals, highlighting the true scale of pathogenic potential within the genus. Phylogenomically, these species are very diverse and have been organised into 19 groups and 30 singleton strains. We find that a substantial number of corynebacteria lack FAS-I, i.e., have no capability for de novo fatty acid biosynthesis and must obtain fatty acids from their habitat; this appears to explain the well-known lipophilic phenotype of some species. In most species, key genes associated with the condensation and maturation of mycolic acids are present, consistent with the reports of mycolic acids in their species descriptions. Conversely, species reported to lack mycolic acids lacked these key genes. Interestingly, Corynebacterium ciconiae, which is reported to lack mycolic acids, appears to possess all genes required for mycolic acid biosynthesis. We suggest that although a mycolic acid-based mycomembrane is widely considered to be the target for interventions by the immune system and chemotherapeutics, the structure is not essential in corynebacteria and is not a prerequisite for pathogenicity or colonisation of animal hosts.

No abstract

Bustamante, Fallon, and Bliss (2006) showed that the a b Signal Detection Theory (SDT) model was more parsimonious, generalizable, and applicable than the classical SDT model. Additionally, they demonstrated that both models provided statistically equivalent and uncorrelated measures of sensitivity and bias under ideal conditions. The purpose of this research was to show the robustness of the a b model for handling extreme responses. We conducted an empirical evaluation of operators' decision-making and two Monte Carlo simulations. Results from the empirical study showed that the a b model provided equivalent yet independent measures of decision-making accuracy and bias, whereas the classical model failed to provide independent measures in the presence of extreme responses. The Monte Carlo simulations showed a similar trend for the superiority of the a b model. Results from this research provide evidence to support the use of the a b model instead of the classical model.

No abstract