Analgesics: New Target and Sources

Saleem, Mohammad; Naz, Huma

doi:10.5772/67853

Cited by 2 publications

(1 citation statement)

References 55 publications

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“…Therefore, this review starts with an outline of the aim and the approach to the topic. The scope is to discuss novel analgesic approaches [1][2][3], including all stages of preclinical evidence and, in particular, approaches in the clinical trial phase. Established pain medications are mentioned, where they serve to discuss concepts or serve as a benchmark for novel approaches.…”

Section: Introductionmentioning

confidence: 99%

Novel Analgesics with Peripheral Targets

Ciotu

Fischer

2020

Neurotherapeutics

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A limited number of peripheral targets generate pain. Inflammatory mediators can sensitize these. The review addresses targets acting exclusively or predominantly on sensory neurons, mediators involved in inflammation targeting sensory neurons, and mediators involved in a more general inflammatory process, of which an analgesic effect secondary to an anti-inflammatory effect can be expected. Different approaches to address these systems are discussed, including scavenging proinflammatory mediators, applying anti-inflammatory mediators, and inhibiting proinflammatory or facilitating anti-inflammatory receptors. New approaches are contrasted to established ones; the current stage of progress is mentioned, in particular considering whether there is data from a molecular and cellular level, from animals, or from human trials, including an early stage after a market release. An overview of publication activity is presented, considering a IuPhar/BPS-curated list of targets with restriction to pain-related publications, which was also used to identify topics.

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Section: Introductionmentioning

confidence: 99%

Novel Analgesics with Peripheral Targets

Ciotu

Fischer

2020

Neurotherapeutics

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The nobel prize in physiology or medicine — 2021

Hagymási

2022

Struct Chem

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The Nobel Assembly at Karolinska Institutet awarded the 2021 Nobel Prize in Physiology and Medicine jointly to David Julius and Ardem Patapoutian for their discoveries of receptors for temperature and touch. TRP and Piezo channels also have several additional physiological functions, so targeting their functions could be a promising therapeutic target for different diseases, including the management of pain.

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Analgesics: New Target and Sources

Cited by 2 publications

References 55 publications

Novel Analgesics with Peripheral Targets

Novel Analgesics with Peripheral Targets

The nobel prize in physiology or medicine — 2021

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