Mount Lawu is one of the volcanoes in Central Java Province with hidden geothermal potential. This research aims to identify geothermal potential areas, especially hydrothermal alteration areas, using Landsat 8 imagery in Mount Lawu, Central Java. Hydrothermal alteration serves as a crucial indicator in the exploration of geothermal potential in an area. Multispectral image processing methods of Landsat 8 are employed to map the distribution patterns of hydrothermal alterations in the study area, together with the anomaly of temperature and heatflux in the surface. This approach involves principal component analysis and spectral alteration indications that combine information from various image channels. Lithology and lineament density analysis strengthen the delineation and analysis of the geothermal potential area. The western-northwestern part of Mount Lawu is the most potential region for geothermal resources based on the distribution of hydrothermal alteration areas and the high density of faulted regions, which are also supported by geothermal manifestations such as hotspring sites in the area.